Quantification of pancreatic islet distribution in situ in mice

American Journal of Physiology - Endocrinology and Metabolism

Volumn 297, Issue 6, 2009, Pages

  Kilimnik, German ^a   Kim, Abraham ^a   Jo, Junghyo ^b   Miller, Kevin ^a   Hara, Manami ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

cell area; Diabetes; Insulinoma; Islets; Pancreatic cells

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ASSAY; CELL COUNT; CELL SHAPE; CELL SIZE; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FLUORESCENCE ANALYSIS; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PANCREAS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SURFACE PROPERTY;

ANIMALS; GREEN FLUORESCENT PROTEINS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, TRANSGENIC; PROMOTER REGIONS, GENETIC;

EID: 72249116296     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00479.2009     Document Type: Article

References (17)

1. Clark A, Clark A, Wells CA, Buley ID, Cruickshank JK, Vanhegan RI, Matthews DR, Cooper GJ, Holman RR, Turner RC. Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes. Diabetes Res 9: 151-159, 1988. (Pubitemid 19105415)
2. Finegood DT, Scaglia L, Bonner-Weir S. Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes 44: 249-256: 1995.
3. Gepts W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14: 619-633, 1965.
4. Hanahan D. Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315: 115-122, 1985. (Pubitemid 15064530)
5. Hara M, Wang X, Kawamura T, Bindokas VP, Dizon RF, Alcoser SY, Magnuson MA, Bell GI. Transgenic mice with green fluorescent protein-labeled pancreatic β-cells. Am J Physiol Endocrinol Metab 284: E177-E183, 2003. (Pubitemid 36082810)
6. Hara M, Dizon RF, Glick BS, Lee CS, Kaestner KH, Piston DW, Bindokas VP. Imaging pancreatic β-cells in the intact pancreas. Am J Physiol Endocrinol Metab 290: E1041-E1047, 2006.
7. Huang C, Snider F, Cross JC. Prolactin receptor is required for normal glucose homeostasis and modulation of beta-cell mass during pregnancy. Endocrinology 150: 1618-1626, 2009.
8. Karnik SK, Chen H, McLean GW, Heit JJ, Gu X, Zhang AY, Fontaine M, Yen MH, Kim SK. Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus. Science 318: 806-809, 2007.
9. Marchetti P, Dotta F, Lauro D, Purrello F. An overview of pancreatic beta-cell defects in human type 2 diabetes: implications for treatment. Regul Pept 146: 4-11, 2008.
10. Matveyenko AV, Butler PC. Relationship between beta-cell mass and diabetes onset. Diabetes Obes Metab 10, Suppl 4: 23-31, 2008.
11. Parsons JA, Brelje TC, Sorenson RL. Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion. Endocrinology 130: 1459-1466, 1992.
12. Parsons JA, Brelje TC, Sorenson RL. Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones. Horm Metab Res 29: 301-307, 1997.
13. Rahier J, Goebbels RM, Henquin JC. Cellular composition of the human diabetic pancreas. Diabetologia 24: 366-371, 1983.
14. Sherry NA, Kushner JA, Glandt M, Kitamura T, Brillantes AM, Herold KC. Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes. Diabetes 55: 3238-3245, 2006. (Pubitemid 44923579)
15. Sorenson RL, Brelje TC. Prolactin receptors are critical to the adaptation of islets to pregnancy. Endocrinology 150: 1566-1569, 2009.
16. Sreenan S, Baldwin AC, Pugh W, Polonsky KS. Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse. Diabetes 48: 989-996, 1999. (Pubitemid 29226344)
17. Van Assche FA, Aerts L, De Prins F. A morphological study of the endocrine pancreas in human pregnancy. Br J Obstet Gynaecol 85: 818-820, 1978. (Pubitemid 9009998)