Development of a unit risk factor for 1,3-butadiene based on an updated carcinogenic toxicity assessment

Risk Analysis

Volumn 29, Issue 12, 2009, Pages 1726-1742

  Grant, Roberta L ^a   Haney, Joseph ^a   Curry, Angela L ^a   Honeycutt, Michael ^a  

^a Texas Commission on Environmental Quality   (United States)

Author keywords

1,3 butadiene; Cancer; Inhalation; Leukemia; Toxicity

Indexed keywords

1,3-BUTADIENE; ADVERSE HEALTH EFFECTS; AIR CONCENTRATIONS; AMBIENT AIR MONITORING; CANCER; CHRONIC EXPOSURE; CONTINUOUS DATA; COVARIATES; COX REGRESSION; DOSE-RESPONSE MODELING; DOSE-RESPONSE MODELS; EARLY LIFE; EPIDEMIOLOGICAL STUDIES; GENERAL POPULATION; GENERAL PUBLICS; HEALTH ASSESSMENTS; LOW-DOSE EXTRAPOLATION; LOWER CONFIDENCE LIMIT; MORTALITY RATE; OCCUPATIONAL EXPOSURE; POINT OF DEPARTURES; REFERENCE VALUES; RISK FACTORS; RISK LEVELS; STYRENE BUTADIENE RUBBER; TEXAS COMMISSION ON ENVIRONMENTAL QUALITY; TOXICITY ASSESSMENT; U.S. ENVIRONMENTAL PROTECTION AGENCY; UNIVERSITY OF ALABAMA AT BIRMINGHAM; VALIDATION STUDY;

AIR POLLUTION; APPROXIMATION THEORY; BUTADIENE; ENVIRONMENTAL PROTECTION AGENCY; ESTIMATION; HEALTH RISKS; RISK ANALYSIS; RISK PERCEPTION; STYRENE; TOXICITY;

OCCUPATIONAL RISKS;

1,3 BUTADIENE; STYRENE;

CANCER; CARCINOGEN; COVARIANCE ANALYSIS; DISEASE INCIDENCE; DOSE-RESPONSE RELATIONSHIP; ENVIRONMENTAL QUALITY; EPIDEMIOLOGY; HEALTH IMPACT; HEALTH RISK; OCCUPATIONAL EXPOSURE; RISK ASSESSMENT; TOXICITY;

AIR MONITORING; AMBIENT AIR; ARTICLE; CANCER EPIDEMIOLOGY; CANCER INCIDENCE; CANCER MORTALITY; CANCER RISK; CARCINOGEN TESTING; ENVIRONMENTAL PROTECTION; GROUPS BY AGE; HUMAN; LEUKEMIA; LONG TERM EXPOSURE; MEASUREMENT ERROR; OCCUPATIONAL CANCER; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HAZARD; OCCUPATIONAL TOXICOLOGY; OVARY HYPERTROPHY; RISK ASSESSMENT; RUBBER INDUSTRY; TOXICITY TESTING; WORKROOM AIR;

AIR POLLUTANTS, OCCUPATIONAL; BUTADIENES; CARCINOGENS; CHEMICAL INDUSTRY; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LEUKEMIA; MULTIVARIATE ANALYSIS; OCCUPATIONAL EXPOSURE; PROPORTIONAL HAZARDS MODELS; RISK ASSESSMENT; RISK FACTORS; TEXAS; UNITED STATES; UNITED STATES ENVIRONMENTAL PROTECTION AGENCY;

ALABAMA; BIRMINGHAM [ALABAMA]; UNITED STATES;

EID: 72249114016     PISSN: 02724332     EISSN: 15396924     Source Type: Journal    
DOI: 10.1111/j.1539-6924.2009.01302.x     Document Type: Article

References (55)

1. Health Assessment of 1,3-Butadiene. Washington, DC : US Environmental Protection Agency, EPA/600/P-98/001F, 2002.
2. Delzell E, Sathiakumar N, Macaluso M. A follow-up study of synthetic rubber workers. Final report prepared under contract to International Institute of Synthetic Rubber Producers, 1995.
3. Delzell E, Sathiakumar N, Hovinga M, Macaluso M, Julian J, Larson R, et al. A follow-up study of synthetic rubber workers. Toxicology, 1996 113 : 182 189.
4. Macaluso M, Larson R, Lynch J, Lipton S, Delzell E. Historical estimation of exposure to 1,3-butadiene, styrene, and dimethyldithiocarbamate among synthetic rubber workers. Journal Occupational Environmental Hygiene, 2004 1 : 371 390.
5. Graff JJ, Sathiakumar N, Macaluso M, Maldonado G, Matthews R, Delzell E. Chemical exposures in the synthetic rubber industry and lymphohematopoietic cancer mortality. Journal Occupational Environmental Medicine, 2005 47 : 916 932. (Pubitemid 41306704)
6. Sathiakumar N, Graff J, Macaluso M, Maldonado G, Matthews R, Delzell E. An updated study of mortality among North American synthetic rubber industry workers. Occupational Environmental Medicine, 2005 62 : 822 829. (Pubitemid 41729770)
7. Delzell E, Sathiakumar N, Graff J, Macaluso M, Maldonado G, Matthews R. An updated study of mortality among North American synthetic rubber industry workers. Res Rep Health Eff Inst, 2006 1 63 discussion 65-74.
8. Sathiakumar N, Delzell E, Cheng H, Lynch J, Sparks W, Macaluso M. Validation of 1,3-butadiene exposure estimates for workers at a synthetic rubber plant. Chemico-Biological Interactions, 2007 166 : 29 43. (Pubitemid 46420699)
9. Cheng H, Sathiakumar N, Graff J, Matthews R, Delzell E. 1,3-Butadiene and leukemia among synthetic rubber industry workers: Exposure-response relationships. Chemico-Biological Interactions, 2007 166 : 15 24. (Pubitemid 46413225)
10. Sielken RL, Jr., Valdez-Flores C, Gargas ML, Kirman CR, Teta MJ, Delzell E. Cancer risk assessment for 1,3-butadiene: Dose-response modeling from an epidemiological perspective. Chemico-Biological Interactions, 2007 166 : 140 149.
11. Tsai SP, Ahmed FS, Ransdell JD, Wendt JK, Donnelly RP. A hematology surveillance study of petrochemical workers exposed to 1,3 butadiene. Journal Occupational Environmental Hygeine, 2005 2 : 508 515.
12. Alder N, Fenty J, Warren F, Sutton AJ, Rushton L, Jones DR, Abrams KR. Meta-analysis of mortality and cancer incidence among workers in the synthetic rubber-producing industry. American Journal Epidemiology, 2006 164 : 405 420.
13. Grant RL, Leopold V, McCant D, Honeycutt M. Spatial and temporal trend evaluation of ambient concentrations of 1,3-butadiene and chloroprene in Texas. Chemico-Biological Interactions, 2007 166 : 44 51.
14. Development Support Document 1,3-Butadiene CAS Registry Number: 106-99-0. Austin, TX : Texas Commission on Environmental Quality. Available at : http://www.tceq.state.tx.us/implementation/tox/dsd/final.html, 2008.
15. Peer Review of the Development Support Document (DSD) for 1,3-Butadiene Prepared by the Texas Commission on Environmental Quality (TCEQ). Cincinnati, OH : Toxicology Excellence for Risk Assessment, http://www.tera.org/peer/TCEQ-, 3butadiene.html, 2007.
16. Responses to Comments Received on the 1,3-Butadiene Development Support Document Original Dated August 2007 and Revised Dated June 2008. Austin, TX : Texas Commission on Environmental Quality. Available at : http://www.tceq.state. tx.us/implementation/tox/dsd/final.html, 2008.
17. Guidelines to Develop Effects Screening Levels, Reference Values, and Unit Risk Factors. Austin, TX : Texas Commission on Environmental Quality, RG-442. Available at : http://www.tceq.state.tx.us/comm-exec/forms-pubs/pubs/rg/ rg-442.html, 2006.
18. Risk Assessment in the Federal Government. Washington, DC : National Research Council, National Academy Press, 1983.
19. Science and Judgment in Risk Assessment. Washington, DC : National Research Council, National Academy Press, 1994.
20. Guidelines for Carcinogen Risk Assessment. Washington, DC : US Environmental Protection Agency, EPA/630/P-03/001B, 2005.
21. Supplemental Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens. Washington, DC : US Environmental Protection Agency, EPA/630/R-03/003F, 2005.
22. Himmelstein MW, Acquavella JF, Recio L, Medinsky MA, Bond JA. Toxicology and epidemiology of 1,3-butadiene. Critical Reviews in Toxicology, 1997 27 : 1 108.
23. Cochrane JE, Skopek TR. Mutagenicity of butadiene and its epoxide metabolites: I. Mutagenic potential of 1,2-epoxybutene, 1,2,3,4-diepoxybutane and 3,4-epoxy-1,2-butanediol in cultured human lymphoblasts. Carcinogenesis, 1994 15 : 713 717.
24. Kligerman AD, Hu Y. Some insights into the mode of action of butadiene by examining the genotoxicity of its metabolites. Chemico-Biological Interactions, 2007 166 : 132 139.
25. Slikker W, Jr., Andersen ME, Bogdanffy MS, Bus JS, Cohen SD, Conolly RB, et al. Dose-dependent transitions in mechanisms of toxicity: Case studies. Toxicology and Applied Pharmacology, 2004 201 : 226 294.
26. Slikker W, Jr., Andersen ME, Bogdanffy MS, Bus JS, Cohen SD, Conolly RB, et al. Dose-dependent transitions in mechanisms of toxicity. Toxicology and Applied Pharmacology, 2004 201 : 203 225.
27. Swenberg JA, Boysen G, Georgieva N, Bird MG, Lewis RJ. Future directions in butadiene risk assessment and the role of cross-species internal dosimetry. Chemico-Biological Interactions, 2007 166 : 78 83.
28. IARC monographs on the evaluation of carcinogenic risks to humans. Volume 97. 1,3-Butadiene, ethylene oxide, and vinyl halides (vinyl fluoride, vinyl chloride and vinyl bromide). International Agency for Research on Cancer (ed). Lyon, France, 2008.
29. National Institute for Occupational Safety and Health. NIOSH Pocket Guide into 119 Carcinogens. Washington, DC : U.S. Department of Health and Human Services, http://cdfc.rug.ac.be/HealthRisk/Butadiene/specific-classification/ NIOSH.htm, 1997.
30. Occupational Safety and Health Administration. Occupational exposure to 1,3-butadiene. Final Rule. 29CFR Part 1910, 1996.
31. American Conference of Governmental Industrial Hygienists, Inc. 1,3-Butadiene. Documentation of the Threshold Limit Values for Chemical Substances, 7th ed. Cincinnati, OH : American Conference of Governmental Industrial Hygienists, Inc, 2001.
32. Department of Health and Human Sevices. The Ninth Report on Carcinogens. Research Triangle Park, NC : U.S. Public Health Services, National Toxicology Program, 2000.
33. Preston RJ. Cancer risk assessment for 1,3-butadiene: Data integration opportunities. Chemico-Biological Interactions, 2007 166 : 150 155.
34. Albertini RJ, Sram RJ, Vacek PM, Lynch J, Wright M, Nicklas JA, Boogaard PJ, et al. Biomarkers for assessing occupational exposures to 1,3-butadiene. Chemico-Biological Interactions, 2001 135 136 : 429 453.
35. Irons RD, Pyatt DW. Dithiocarbamates as potential confounders in butadiene epidemiology. Carcinogenesis, 1998 19 : 539 542.
36. Irons RD, Stillman WS, Pyatt DW, Yang Y, Le A, Gustafson DL, Hua Zheng J. Comparative toxicity of dithiocarbamates and butadiene metabolites in human lymphoid and bone marrow cells. Chemico-Biological Interactions, 2001 135 136 : 615 625.
37. Steenland K. Smoothing is soothing, and splines are fine. Occupational and Environmental Medicine, 2005 62 : 141 142.
38. Health Risks of Radon and Other Internally Deposited Alpha- Emitters. Biological Effects of Ionizing Radiation IV (BEIR IV). Washington DC : National Research Council, National Academy Press, 1988.
39. Crude total US mortality rates, leukemia, for 1998-2003 by race and sex. SEER. Surveillance, Epidemiology, and End Results, http://www.seer.cancer.gov, 2006.
40. Arias E. United States life tables, 2000. National Vital Statistics Reports, 2002. p 3.
41. Review of the Office of Research and Development's Draft Health Risk Assessment of 1,3-Butadiene Prepared by the Environmental Health Committee of the Science Advisory Board (SAB). Washington, DC : US Environmental Protection Agency, EPA-SAB-EHC-99-003, 1998.
42. Johnsrud EK, Koukouritaki SB, Divakaran K, Brunengraber LL, Hines RN, McCarver DG. Human hepatic CYP2E1 expression during development. Journal of Pharmacology and Experimental Therapeutics, 2003 307 : 402 407.
43. Levine EG, Bloomfield CD. Leukemias and myelodysplastic syndromes secondary to drug, radiation, and environmental exposure. Seminars in Oncology, 1992 19 : 47 84.
44. Pyatt DW, Hays SM, Cushing CA. Do children have increased susceptibility for developing secondary acute myelogenous leukemia Chemico-Biological Interactions, 2005 153 154 : 223 229.
45. Pyatt DW, Aylward LL, Hays SM. Is age an independent risk factor for chemically induced acute myelogenous leukemia in children Journal of Toxicology and Environmental Health Part B Critical Reviews, 2007 10 : 379 400.
46. Chemical and Radiation Leukemogenesis in Humans and Rodents and the Value of Rodent Models for Assessing Risks of Lymphohematopoietic Cancers. Washington, DC : US Environmental Protection Agency, EPA/600/R-97/090, N 1997.
47. Albertini RJ, Sram RJ, Vacek PM, Lynch J, Rossner P, Nicklas JA, McDonald JD, et al. Molecular epidemiological studies in 1,3-butadiene exposed Czech workers: Female-male comparisons. Chemico-Biological Interactions, 2007 166 : 63 77.
48. LLS. Leukemia and Lymphoma Society. Available at:http://www.leukemia- lymphoma.org/all-page.adp?item-id=9346, 2008.
49. Sathiakumar N, Delzell E. A follow-up study of women in the synthetic rubber industry: Study methods. Chemico-Biological Interactions, 2007 166 : 25 28.
50. Sathiakumar N, Delzell E. A follow-up study of women in the synthetic rubber industry. Draft report submitted to International Institute of Synthetic Rubber Producers (IISRP), under review, 2007.
51. Gordon SM, Callahan PJ, Nishioka MG, Brinkman MC, O'Rourke MK, Lebowitz MD, Moschandreas DJ. Residential environmental measurements in the national human exposure assessment survey (NHEXAS) pilot study in Arizona: Preliminary results for pesticides and VOCs. Journal of Exposure Analysis and Environmental Epidemiology, 1999 9 : 456 470.
52. Sapkota A, Buckley TJ. The mobile source effect on curbside 1,3-butadiene, benzene, and particle-bound polycyclic aromatic hydrocarbons assessed at a tollbooth. Journal of Air and Waste Managagement Association, 2003 53 : 740 748.
53. Sapkota A, Williams D, Buckley TJ. Tollbooth workers and mobile source-related hazardous air pollutants: How protective is the indoor environment Environonmental Science and Technology, 2005 39 : 2936 2943.
54. Canadian Environmental Protection Act Priority Substances List Health Assessment: 1,3-Butadiene Draft for Second Stage Peer Review. Ottawa, Canada : Health Canada, 1998.
55. Teta MJ, Tran NL, Mink PJ, Barraj LM. Validity of using background leukemia incidence rates with cohort mortality-based potency estimates to calculate excess lifetime risk. Human and Ecological Risk Assessment, 2004 10 : 923 938.