Pyrrolidine analogues of lobelane: Relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2)

Journal of Medicinal Chemistry

Volumn 52, Issue 23, 2009, Pages 7878-7882

  Vartak, Ashish P ^a   Nickell, Justin R ^a   Chagkutip, Jaturaporn ^a   Dwoskin, Linda P ^a   Crooks, Peter A ^a  

^a University of Kentucky   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL CIS 2,5 DI(2 BENZYL)PYRROLIDINE HYDROCHLORIDE; 1 METHYL CIS 2,5 DI(2 PHENETHYL)PYRROLIDINE HYDROCHLORIDE; 1 METHYL CIS 2,5 DI(3 PHENYLPROPYL)PYRROLIDINE HYDROCHLORIDE; 1 METHYL DI (2 PHENETHYL)PYRROLIDINE HYDROCHLORIDE; 2 2,5 DI(2 PHENETHYL)TETRAHYDRO 1H 1 PYRROLYL 2 PHENYLETHAN 1 OL; 2 [2,5 DI(2 PHENETHYL)TETRAHYDRO 1H 1 PYRROLYL] 2 PHENYLETHAN 1 OL; CIS 2,5 DI(2 BENZYL)PYRROLIDINE HYDROCHLORIDE; CIS 2,5 DI(2 PHENETHYL)PYRROLIDINE HYDROCHLORIDE; CIS 2,5 DI(3 PHENYLPROPYL)PYRROLIDINE HYDROCHLORIDE; DI(2 PHENETHYL)PYRROLIDINE HYDROCHLORIDE; DIHYDROTETRABENAZINE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG; VESICULAR MONOAMINE TRANSPORTER 2;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG STRUCTURE; MOLECULAR INTERACTION; PROTEIN FUNCTION; STRUCTURE ACTIVITY RELATION; TRANSPORT KINETICS;

BINDING SITES; LOBELINE; PROTEIN BINDING; PYRROLIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRABENAZINE; VESICULAR MONOAMINE TRANSPORT PROTEINS;

EID: 72249105289     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900770h     Document Type: Article

References (14)

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