Cardiac transplantation and/or mechanical circulatory support device placement using heparin anti-coagulation in the presence of acute heparin-induced thrombocytopenia

Journal of Heart and Lung Transplantation

Volumn 29, Issue 1, 2010, Pages 53-60

  Zucker, Mark J ^a   Sabnani, Indu ^a   Baran, David A ^a   Balasubramanian, Sangeetha ^a   Camacho, Margarita ^a  

^a NEWARK BETH ISRAEL MEDICAL CENTER   (United States)

Author keywords

heart transplantation; heparin; heparin antibodies; mechanical cardiac assist; thrombocytopenia

Indexed keywords

ARGATROBAN; HEPARIN; METHYLPREDNISOLONE; PROTAMINE;

ADULT; AGED; ANTICOAGULATION; ARTERY THROMBOSIS; ARTICLE; ASSISTED CIRCULATION; CARDIOPULMONARY BYPASS; DEVICE; DRUG DOSE TITRATION; DRUG SAFETY; DRUG WITHDRAWAL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEART TRANSPLANTATION; HEPARIN INDUCED THROMBOCYTOPENIA; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; IMPLANT; LOW DRUG DOSE; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MECHANICAL CIRCULATORY SUPPORT DEVICE; MORBIDITY; OUTCOME ASSESSMENT; PARTIAL THROMBOPLASTIN TIME; POSTOPERATIVE CARE; PREOPERATIVE CARE; PRIORITY JOURNAL; SURGICAL MORTALITY; SURGICAL TECHNIQUE; SURVIVAL RATE; THROMBOCYTE COUNT; VEIN THROMBOSIS;

ADOLESCENT; ADULT; AGED; ANTIBODIES; ANTICOAGULANTS; CARDIOPULMONARY BYPASS; FEMALE; HEART FAILURE; HEART TRANSPLANTATION; HEART-ASSIST DEVICES; HEPARIN; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS; THROMBOCYTOPENIA; TREATMENT OUTCOME; VENTRICULAR DYSFUNCTION, LEFT;

EID: 72249102823     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.healun.2009.08.016     Document Type: Article

References (38)

1. Vincentelli A., Jude B., and Belisle S. Antithrombotic therapy in cardiac surgery. Can J Anaesth 53 suppl (2006) S89-S102
2. Yavari M., and Becker R.C. Anticoagulant therapy during cardiopulmonary bypass. J Thromb Thrombolysis 26 (2008) 218-228
3. Pouplard C., May M.A., Iochmann S., et al. Antibodies to platelet factor 4-heparin after cardiopulmonary bypass in patients anticoagulated with unfractionated heparin or a low-molecular-weight heparin: clinical implications for heparin-induced thrombocytopenia. Circulation 99 (1999) 2530-2536
4. Warkentin T.E. Platelet count monitoring and laboratory testing for heparin-induced thrombocytopenia. Arch Pathol Lab Med 126 (2002) 1415-1423
5. Warkentin T.E. Heparin-induced thrombocytopenia: pathogenesis and management. Br J Haematol 121 (2003) 535-555
6. Warkentin T.E. An overview of the heparin-induced thrombocytopenia syndrome. Semin Thromb Hemost 30 (2004) 273-283
7. Warkentin T.E., Chong B.H., and Greinacher A. Heparin-induced thrombocytopenia: towards consensus. Thromb Haemost 79 (1998) 1-7
8. Warkentin T.E., and Kelton J.G. Temporal aspects of heparin-induced thrombocytopenia. N Engl J Med 344 (2001) 1286-1292
9. Koster A., and Kukucka M. Anticoagulation of patients with heparin-induced thrombocytopenia in cardiac surgery. Curr Opin Anaesthesiol 17 (2004) 71-74
10. Warkentin T.E., Greinacher A., Koster A., et al. Treatment and prevention of heparin-induced thrombocytopenia: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest 133 suppl (2008) 340S-380S
11. Potzsch B., Klovekorn W.P., and Madlener K. Use of heparin during cardiopulmonary bypass in patients with a history of heparin-induced thrombocytopenia. N Engl J Med 343 (2000) 515
12. Schreiber C., Dietrich W., Braun S., et al. Use of heparin upon reoperation in a pediatric patient with heparin-induced thrombocytopenia after disappearance of antibodies. Clin Res Cardiol 95 (2006) 379-382
13. Poetzsch B.M.K. Management of cardiopulmonary bypass anticoagulation in patients with heparin-induced thrombocytopenia. In: Warkentin T.E., and Greinacher A. (Eds). Heparin-induced thrombocytopenia. 3rd ed. (2004), Marcel Dekker, New York 531-551
14. Carrier M., Robitaille D., Perrault L.P., et al. Heparin versus danaparoid in off-pump coronary bypass grafting: results of a prospective randomized clinical trial. J Thorac Cardiovasc Surg 125 (2003) 325-329
15. Dyke C.M., Smedira N.G., Koster A., et al. A comparison of bivalirudin to heparin with protamine reversal in patients undergoing cardiac surgery with cardiopulmonary bypass: the EVOLUTION-ON study. J Thorac Cardiovasc Surg 131 (2006) 533-539
16. Koster A., Hansen R., Kuppe H., et al. Recombinant hirudin as an alternative for anticoagulation during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia type II: a 1-year experience in 57 patients. J Cardiothorac Vasc Anesth 14 (2000) 243-248
17. Koster A., Loebe M., Mertzlufft F., et al. Cardiopulmonary bypass in a patient with heparin-induced thrombocytopenia II and impaired renal function using heparin and the platelet GP IIb/IIIa inhibitor tirofiban as anticoagulant. Ann Thorac Surg 70 (2000) 2160-2161
18. Warkentin T.E., Dunn G.L., and Cybulsky I.J. Off-pump coronary artery bypass grafting for acute heparin-induced thrombocytopenia. Ann Thorac Surg 72 (2001) 1730-1732
19. Schenk S., El-Banayosy A., Prohaska W., et al. Heparin-induced thrombocytopenia in patients receiving mechanical circulatory support. J Thorac Cardiovasc Surg 131 (2006) 1373-1381 e4
20. Keeling D., Davidson S., and Watson H. The management of heparin-induced thrombocytopenia. Br J Haematol 133 (2006) 259-269
21. Greinacher A., Farner B., Kroll H., et al. Clinical features of heparin-induced thrombocytopenia including risk factors for thrombosis. A retrospective analysis of 408 patients. Thromb Haemost 94 (2005) 132-135
22. Juhl D., Eichler P., Lubenow N., et al. Incidence and clinical significance of anti-PF4/heparin antibodies of the IgG, IgM, and IgA class in 755 consecutive patient samples referred for diagnostic testing for heparin-induced thrombocytopenia. Eur J Haematol 76 (2006) 420-426
23. Arepally G.M., and Ortel T.L. Clinical practice. Heparin-induced thrombocytopenia. N Engl J Med 355 (2006) 809-817
24. Warkentin T.E. Clinical picture of heparin-induced thrombocytopenia. In: Warkentin T.E., and Greinacher A. (Eds). Heparin-induced thrombocytopenia (2007), Informa Healthcare, New York 21-66
25. Christiansen S., Jahn U.R., Meyer J., et al. Successful cardiac transplantation after Novacor implantation in a HIT II-patient using heparin. J Cardiovasc Surg (Torino) 42 (2001) 769-771
26. Mertzlufft F., Kuppe H., and Koster A. Management of urgent high-risk cardiopulmonary bypass in patients with heparin-induced thrombocytopenia type II and coexisting disorders of renal function: use of heparin and epoprostenol combined with on-line monitoring of platelet function. J Cardiothorac Vasc Anesth 14 (2000) 304-308
27. Nuttall G.A., Oliver Jr. W.C., Santrach P.J., et al. Patients with a history of type II heparin-induced thrombocytopenia with thrombosis requiring cardiac surgery with cardiopulmonary bypass: a prospective observational case series. Anesth Analg 96 (2003) 344-350
28. Selleng S., Haneya A., Hirt S., et al. Management of anticoagulation in patients with subacute heparin-induced thrombocytopenia scheduled for heart transplantation. Blood 112 (2008) 4024-4027
29. Wadia Y., Cooper J.R., Bracey A.W., et al. Intraoperative anticoagulation management during cardiac transplantation for a patient with heparin-induced thrombocytopenia and a left ventricular assist device. Tex Heart Inst J 35 (2008) 62-65
30. Crespo E.M., Oliveira G.B., Honeycutt E.F., et al. Evaluation and management of thrombocytopenia and suspected heparin-induced thrombocytopenia in hospitalized patients: the Complications After Thrombocytopenia Caused by Heparin (CATCH) registry. Am Heart J 157 (2009) 651-657
31. Janatpour K.A., Gosselin R.C., Dager W.E., et al. Usefulness of optical density values from heparin-platelet factor 4 antibody testing and probability scoring models to diagnose heparin-induced thrombocytopenia. Am J Clin Pathol 127 (2007) 429-433
32. Schroder J.N., Daneshmand M.A., Villamizar N.R., et al. Heparin-induced thrombocytopenia in left ventricular assist device bridge-to-transplant patients. Ann Thorac Surg 84 (2007) 841-845
33. Lubenow N., Selleng S., Wollert H.G., et al. Heparin-induced thrombocytopenia and cardiopulmonary bypass: perioperative argatroban use. Ann Thorac Surg 75 (2003) 577-579
34. Dellaria S.M., Greilich P.E., and Sarode R. Urgent cardiac surgery in a patient with a remote history of heparin-induced thrombocytopenia: use of the anti-PF4/heparin ELISA confirmatory test. Anesth Analg 107 (2008) 379-381
35. Lo G.K., Juhl D., Warkentin T.E., et al. Evaluation of pretest clinical score (4 T's) for the diagnosis of heparin-induced thrombocytopenia in two clinical settings. J Thromb Haemost 4 (2006) 759-765
36. Lubenow N., Kempf R., Eichner A., et al. Heparin-induced thrombocytopenia: temporal pattern of thrombocytopenia in relation to initial use or reexposure to heparin. Chest 122 (2002) 37-42
37. Matthai Jr. W.H., and Cines D.B. Towards a diagnosis of heparin-induced thrombocytopenia after cardiopulmonary bypass. J Thromb Haemost 2 (2004) 1879-1881
38. Warkentin T.E. Think of HIT. American Society of Hematology educational program book (2006), American Society of Hematology, Washington, DC 408-414