Heparin-induced thrombocytopenia in patients receiving mechanical circulatory support

Journal of Thoracic and Cardiovascular Surgery

Volumn 131, Issue 6, 2006, Pages

  Schenk, Soren ^a   El Banayosy, Aly ^a   Prohaska, Wolfgang ^a   Arusoglu, Latif ^a   Morshuis, Michiel ^a   Koester Eiserfunke, Wilhelm ^a   Kizner, Lukasz ^a   Murray, Edward ^a   Eichler, Petra ^b   Koerfer, Reiner ^a   Greinacher, Andreas ^b  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; HEPARIN; THROMBOCYTE ANTIBODY; THROMBOCYTE FACTOR 4;

ARTICLE; BLOOD SAMPLING; CARDIOVASCULAR RISK; DRUG HYPERSENSITIVITY; DRUG INDUCED DISEASE; DRUG TOLERANCE; FEMALE; FIBRINOGEN BLOOD LEVEL; HUMAN; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; SEX DIFFERENCE; THROMBOCYTE ACTIVATION; THROMBOCYTOPENIA; THROMBOEMBOLISM;

EID: 33646848620     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2006.01.048     Document Type: Article

References (26)

1. Kelton J.G. The pathophysiology of heparin-induced thrombocytopenia. biological basis for treatment. Chest. 127 (2005) 9S-20S
2. Warkentin T.E. Heparin-induced thrombocytopenia. pathogenesis and management. Br J Haematol. 121 (2003) 535-555
3. Bauer T.L., Arepally G., Konkle B.A., Mestichelli B., Shapiro S.S., Cines D.B., et al. Prevalence of heparin-associated antibodies without thrombosis in patients undergoing cardiopulmonary bypass surgery. Circulation. 95 (1997) 1242-1246
4. Pouplard C., May M.A., Regina S., Marchand M., Fusciardi J., and Gruel Y. Changes in platelet count after cardiac surgery can effectively predict the development of pathogenic heparin-dependent antibodies. Br J Haematol. 128 (2005) 837-841
5. Warkentin T.E., and Greinacher A. Heparin-induced thrombocytopenia and cardiac surgery. Ann Thorac Surg. 76 (2003) 2121-2131
6. Warkentin T.E., Sheppard J.A., Horsewood P., Simpson P.J., Moore J.C., and Kelton J.G. Impact of the patient population on the risk for heparin-induced thrombocytopenia. Blood. 96 (2000) 1703-1708
7. Warkentin T.E., Roberts R.S., Hirsh J., and Kelton J.G. An improved definition of immune heparin-induced thrombocytopenia in postoperative orthopedic patients. Arch Intern Med. 163 (2003) 2518-2524
8. El-Banayosy A., Korfer R., Arusoglu L., Kizner L., Morshuis M., Milting H., et al. Device and patient management in a bridge-to-transplant setting. Ann Thorac Surg. 71 (2001) S98-S102 discussion S114-5
9. Greinacher A., Michels I., Kiefel V., and Mueller-Eckhardt C. A rapid and sensitive test for diagnosing heparin-associated thrombocytopenia. Thromb Haemost. 66 (1991) 734-736
10. Greinacher A., Amiral J., Dummel V., Vissac A., Kiefel V., and Mueller-Eckhardt C. Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin-induced platelet activation test, and platelet factor 4/heparin enzyme-linked immunosorbent assay. Transfusion. 34 (1994) 381-385
11. Koster A., Loebe M., Sodian R., Potapov E.V., Hansen R., Muller J., et al. Heparin antibodies and thromboembolism in heparin-coated and noncoated ventricular assist devices. J Thorac Cardiovasc Surg. 121 (2001) 331-335
12. Dewald O., Fischlein T., Vetter H.O., Schmitz C., Godje O., Gohring P., et al. Platelet morphology in patients with mechanical circulatory support. Eur J Cardiothorac Surg. 12 (1997) 634-641
13. Houel R., Mazoyer E., Boval B., Kirsch M., Vermes E., Drouet L., et al. Platelet activation and aggregation profile in prolonged external ventricular support. J Thorac Cardiovasc Surg. 128 (2004) 197-202
14. Untch B., Ahmad S., Jeske W.P., Messmore H.L., Hoppensteadt D.A., Walenga J.M., et al. Prevalence, isotype, and functionality of antiheparin-platelet factor 4 antibodies in patients treated with heparin and clinically suspected for heparin-induced thrombocytopenia. The pathogenic role of IgG. Thromb Res. 105 (2002) 117-123
15. Hourigan L.A., Walters D.L., Keck S.A., and Dec G.W. Heparin-induced thrombocytopenia. a common complication in cardiac transplant recipients. J Heart Lung Transplant. 21 (2002) 1283-1289
16. Fabris F., Luzzatto G., Soini B., Ramon R., Scandellari R., Randi M.L., et al. Risk factors for thrombosis in patients with immune mediated heparin-induced thrombocytopenia. J Intern Med. 252 (2002) 149-154
17. Chilver-Stainer L., Lammle B., and Alberio L. Titre of anti-heparin/PF4-antibodies and extent of in vivo activation of the coagulation and fibrinolytic systems. Thromb Haemost. 91 (2004) 276-282
18. Warkentin T.E., and Kelton J.G. Temporal aspects of heparin-induced thrombocytopenia. N Engl J Med. 344 (2001) 1286-1292
19. Greinacher A., Farner B., Kroll H., Kohlmann T., Warkentin T.E., and Eichler P. Clinical features of heparin-induced thrombocytopenia including risk factors for thrombosis. A retrospective analysis of 408 patients. Thromb Haemost. 94 (2005) 132-135
20. Greinacher A., Eichler P., Lietz T., and Warkentin T.E. Replacement of unfractionated heparin by low-molecular-weight heparin for postorthopedic surgery antithrombotic prophylaxis lowers the overall risk of symptomatic thrombosis because of a lower frequency of heparin-induced thrombocytopenia. Blood. 106 (2005) 2921-2922
21. Frazier O.H., Rose E.A., Oz M.C., Dembitsky W., McCarthy P., Radovancevic B., et al. Multicenter clinical evaluation of the HeartMate vented electric left ventricular assist system in patients awaiting heart transplantation. J Thorac Cardiovasc Surg. 122 (2001) 1186-1195
22. Navia J.L., McCarthy P.M., Hoercher K.J., Feng J., Jeevantham R., Smedira N.G., et al. Do left ventricular assist device (LVAD) bridge-to-transplantation outcomes predict the results of permanent LVAD implantation?. Ann Thorac Surg. 74 (2002) 2051-2062 discussion 2062-3
23. Eichler P., Budde U., Haas S., Kroll H., Loreth R.M., Meyer O., et al. First workshop for detection of heparin-induced antibodies. validation of the heparin-induced platelet-activation test (HIPA) in comparison with a PF4/heparin ELISA. Thromb Haemost. 81 (1999) 625-629
24. Warkentin T.E., and Heddle N.M. Laboratory diagnosis of immune heparin-induced thrombocytopenia. Curr Hematol Rep. 2 (2003) 148-157
25. Greinacher A., and Warkentin T.E. Recognition, treatment, and prevention of heparin-induced thrombocytopenia. review and update. Thromb Res. (2005) Aug 31. [Epub ahead of print.]
26. Merry A.F. Bivalirudin, blood loss, and graft patency in coronary artery bypass surgery. Semin Thromb Hemost. 30 (2004) 337-346