Clomiphene citrate and enclomiphene for the treatment of hypogonadal androgen deficiency

Expert Opinion on Investigational Drugs

Volumn 18, Issue 12, 2009, Pages 1947-1955

  Kaminetsky, Jed ^a   Hemani, Micah L ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Androgen replacement; Clomiphene citrate; Enclomiphene citrate; Secondary hypogonadism

Indexed keywords

ALPHA TOCOPHEROL; CLOMIFENE CITRATE; ENCLOMIFENE; ENCLOMIFENE CITRATE; FOLLITROPIN; LUTEINIZING HORMONE; PLACEBO; TAMOXIFEN; TESTOSTERONE; TOREMIFENE; ZUCLOMIFENE;

ACUTE ABDOMEN; ANDROGEN DEFICIENCY; ANDROGEN THERAPY; AZOOSPERMIA; BLOATING; BREAST DISEASE; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; DEPRESSION; DERMATITIS; DIARRHEA; DIZZINESS; DRUG ERUPTION; DRUG EXCRETION; DRUG INDUCED HEADACHE; DRUG METABOLISM; DRUG SAFETY; DRUG TOLERABILITY; ERECTILE DYSFUNCTION; FATIGUE; GONAD DYSFUNCTION; GONAD FUNCTION; GYNECOMASTIA; HAIR LOSS; HOT FLUSH; HUMAN; HYPOGONADISM; HYPOGONADOTROPIC HYPOGONADISM; HYPOPHYSIS DISEASE; HYPOPHYSIS FUNCTION; HYPOTHALAMUS DISEASE; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; INCIDENCE; INCREASED APPETITE; INSOMNIA; MALE INFERTILITY; MASTALGIA; NAUSEA AND VOMITING; NERVOUSNESS; OVARY HYPERTROPHY; PATHOGENESIS; PELVIS PAIN SYNDROME; RANDOMIZED CONTROLLED TRIAL; REVIEW; SIDE EFFECT; SPERMATOGENESIS; TREATMENT OUTCOME; URINARY FREQUENCY; URINE VOLUME; UTERUS BLEEDING; VERTIGO; VISUAL DISORDER; WEIGHT CHANGE;

ANDROGENS; CLOMIPHENE; ESTROGEN ANTAGONISTS; HUMANS; HYPOGONADISM; INFERTILITY, MALE; MALE; PITUITARY GLAND;

EID: 72249096282     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543780903405608     Document Type: Review

References (47)

1. American Association of Clinical Endocrinologists Medical Guidelines for clinical practice for the evaluation and treament of hypogonadism in adult male patients-2002 update. Endocr Pract 2002;8(6):440-456
2. Wang C, Swerdloff RS. Pratical aspects of testosterone substitution. J Endocrinol Invest 2005;28:109-111
3. Neaves WB, Johnson L, Porter JC, et al. Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men. J Clin Endocrinol Metab 1984;59:756-763 (Pubitemid 14012503)
4. Lapauw B, Goemaere S, Zmierczak H, et al. The decline of serum testosterone levels in community-dwelling men over 70 years of age: descriptive data and predictors of longitudinal changes. Eur J Endocrinol 2008;159:459-468
5. Harman SM, Metter EJ, Tobin JD, et al. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab 2001;86:724-731
6. Albaaj F, Sivalingham M, Haynes P, et al. Prevalence of hypogonadism in male patients with renal failure. Postgrad Med J 2006;82:693-696
7. Corona G, Mannucci E, Forti G, Maggi M. Hypogonadism, ED, metabolic syndrome and obesity: a pathological link supporting cardiovascular diseases. Int J Androl 2009 [Epub ahead of print]
8. Traish AM, Guay A, Feeley R, Saad F. The dark side of testosterone deficiency: I. Metabolic syndrome and erectile dysfunction. J Androl 2009;30:10-22
9. Cooke WT, Peeney AL, Hawkins CF. Symptoms, signs and diagnostic features of idiopathic steatorrhoea. Q J Med 1953;22:59-78
10. Farthing MJ, Edwards CR, Rees LH, Dawson AM. Male gonadal function in coeliac disease: 1. Sexual dysfunction, infertility, and semen quality. Gut 1982;23:608-614
11. Robinson RJ, Iqbal SJ, Al-Azzawi F, et al. Sex hormone status and bone metabolism in men with Crohn's disease. Aliment Pharmacol Ther 1998;12:21-25
12. Karges B, de Roux N. Molecular genetics of isolated hypogonadotropic hypogonadism and Kallmann syndrome. Endocr Dev 2005;8:67-80
13. Conway GS. Clinical manifestations of genetic defects affecting gonadotrophins and their receptors. Clin Endocrinol (Oxf) 1996;45:657-663
14. Yau I, Vuong T, Garant A, et al. Risk of hypogonadism from scatter radiation during pelvic radiation in male patients with rectal cancer. Int J Radiat Oncol Biol Phys 2009;74(5):1481-1486
15. Mitchell RT, Saunders PT, Sharpe RM, et al. Male fertility and strategies for fertility preservation following childhood cancer treatment. Endocr Dev 2009;15:101-134
16. Araujo AB, O'Donnell AB, Brambilla DJ, et al. Prevalence and incidence of androgen deficiency in middle-aged and older men: estimates from the Massachusetts Male Aging Study. J Clin Endocr 2004;89:5920-5926
17. Isidori AM, Giannetta E, Lenzi A. Male hypogonadism. Pituitary 2008;11:171-180
18. Bhasin S, Cunningham GR, Hayes FJ, et al. Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2006;91:1995-2010
19. Edelstein D, Sivanandy M, Shahani S, Basaria S. The latest options and future agents for treating male hypogonadism. Expert Opin Pharmacother 2007;8:2991-3008
20. Male Hypogonadism. Merck Manual Online. Morley JE, Kaiser FE, Perry HM III, et al. Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. Metabolism 1997;46:410-413
21. Longcope C, Sato K, McKay C, Horton R. Aromatization by splanchnic tissue in men. J Clin Endocrinol Metab 1984;58:1089-1093
22. Ismail AA, Barth JH. Endocrinology of gynaecomastia. Ann Clin Biochem 2001;38:596-607
23. Sokol RZ. Endocrinology of male infertility: evaluation and treatment. Semin Reprod Med 2009;27:149-158
24. Vermeulen A. Androgen replacement therapy in the aging male-a critical evaluation. J Clin Endocrinol Metab 2001;86:2380-2390
25. Holzbeierlein JM. Managing complications of androgen deprivation therapy for prostate cancer. Urol Clin North Am 2006;33:181-90, vi
26. Katznelson L, Finkelstein JS, Schoenfeld DA, et al. Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism. J Clin Endocrinol Metab 1996;81:4358-65
27. Barrett-Connor E, Von Muhlen DG, Kritz-Silverstein D. Bioavailable testosterone and depressed mood in older men: the Rancho Bernardo Study. J Clin Endocrinol Metab 1999;84:573-577
28. Blute M, Hakimian P, Kashanian J, et al. Erectile dysfunction and testosterone deficiency.Front HormRes 2009;37:108-122
29. Buvat J, Lemaire A. Endocrine screening in 1,022 men with erectile dysfunction: clinical significance and cost-effective strategy. J Urol 1997;158:1764-1767
30. Guay AT, Jacobson J, Perez JB, et al. Clomiphene increases free testosterone levels in men with both secondary hypogonadism and erectile dysfunction: who does and does not benefit? Int J Impot Res 2003;15:156-165
31. Zonszein J. Diagnosis and management of endocrine disorders of erectile dysfunction. Urol Clin North Am 1995;22:789-802
32. Petak SM, Nankin HR, Spark RF, et al. The American Society for Reproductive Medicine, Birmingham, Alabama. Androgen deficiency in the aging male. Fertil Steril 2008;90:S83-7
33. Pallottini V, Bulzomi P, Galluzzo P, et al. Estrogen regulation of adipose tissue functions: involvement of estrogen receptor isoforms. Infect Disord Drug Targets 2008;8:52-60
34. Romeo JH, Ybarra J. Hypogonadal hypogonadism and osteoporosis in men. Nurs Clin North Am 2007;42:87-99, vii-viii
35. Nuti R, Martini G, Merlotti D, et al. Bone metabolism in men: role of aromatase activity. J Endocrinol Invest 2007;30:18-23
36. Kaaja RJ. Metabolic syndrome and the menopause. Menopause Int 2008;14:21-25
37. Guise TA, Oefelein MG, Eastham JA, et al. Estrogenic side effects of androgen deprivation therapy. Rev Urol 2007;9:163-180
38. Ghanem H, Shaeer O, El-Segini A. Combination clomiphene citrate and antioxidant therapy for idiopathic male infertility: a randomized controlled trial. Fertil Steril 2009 [Epub ahead of print]
39. Tomlinson JW, Holden N, Hills RK, et al. Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group. Lancet 2001;357:425-31
40. Jain P, Rademaker AW, McVary KT. Testosterone supplementation for erectile dysfunction: results of a meta-analysis. J Urol 2000;164:371-375
41. Wang C, Alexander G, Berman N, et al. Testosterone replacement therapy improves mood in hypogonadal men-a clinical research center study. J Clin Endocrinol Metab 1996;81:3578-3583
42. Shabsigh A, Kang Y, Shabsign R, et al. Clomiphene citrate effects on testosterone/estrogen ratio in male hypogonadism. J Sex Med 2005;2:716-721
43. Brand TC, Canby-Hagino E, Thompson IM. Testosterone replacement therapy and prostate cancer: a word of caution. Curr Urol Rep 2007;8:185-189
44. Bardin CW, Swerdloff RS, Santen RJ. Androgens: risks and benefits. J Clin Endocrinol Metab 1991;73:4-7
45. Tenover JS, Bremner WJ. The effects of normal aging on the response of the pituitary-gonadal axis to chronic clomiphene administration in men. J Androl 1991;12:258-263
46. Goldstein SR, Siddhanti S, Ciaccia AV, Plouffe L Jr. A pharmacological review of selective oestrogen receptor modulators. Hum Reprod Update 2000;6:212-224
47. Pasqualotto FF, Fonseca GP, Pasqualotto EB. Azoospermia after treatment with clomiphene citrate in patients with oligospermia. Fertil Steril 2008;90:2014 e11-2