15-deoxy-Δ12,14-PGJ2 induces cell cycle arrest and apoptosis of haematopoietic progenitors

British Journal of Haematology

Volumn 148, Issue 1, 2010, Pages 173-175

  Pacienza, Natalia ^a   D'Atri, Lina P ^a   Pozner, Roberto G ^a   Negrotto, Soledad ^a   Malaver, Elisa ^a   Torres, Oscar ^a   Schattner, Mirta ^a  

^a ACADEMIA NACIONAL DE MEDICINA   (Argentina)

Author keywords

15 deoxy D12,14 prostaglandin J 2; Apoptosis; CD34+ cells; Peroxisome proliferator activated receptor

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; CASPASE 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; DRUG MECHANISM; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LETTER; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL;

APOPTOSIS; CELL CYCLE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMATOPOIETIC STEM CELLS; HUMANS; PROSTAGLANDIN D2;

EID: 72249094569     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2009.07910.x     Document Type: Letter

References (10)

1. Akbiyik, F., Ray, D.M., Gettings, K.F., Blumberg, N., Francis, C.W. Phipps, R.P. (2004) Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanes. Blood, 104, 1361 1368.
2. Cumming, R.C., Lightfoot, J., Beard, K., Youssoufian, H., O'Brien, P.J. Buchwald, M. (2001) Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1. Nature Medicine, 7, 814 820.
3. Greene, M.E., Pitts, J., McCarville, M.A., Wang, X.S., Newport, J.A., Edelstein, C., Lee, F., Ghosh, S. Chu, S. (2000) PPARgamma: observations in the hematopoietic system. Prostaglandins & Other Lipid Mediators, 62, 45 73.
4. Grommes, C., Landreth, G.E. Heneka, M.T. (2004) Antineoplastic effects of peroxisome proliferator-activated receptor gamma agonists. The Lancet Oncology, 5, 419 429.
5. Ito, K., Hirao, A., Arai, F., Matsuoka, S., Takubo, K., Hamaguchi, I., Nomiyama, K., Hosokawa, K., Sakurada, K., Nakagata, N., Ikeda, Y., Mak, T.W. Suda, T. (2004) Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature, 431, 997 1002.
6. Nagasawa, E., Abe, Y., Nishimura, J., Yanase, T., Nawata, H. Muta, K. (2005) Pivotal role of peroxisome proliferator-activated receptor gamma (PPARgamma) in regulation of erythroid progenitor cell proliferation and differentiation. Experimental Hematology, 33, 857 864.
7. Negrotto, S., Pacienza, N., D'Atri, L.P., Pozner, R.G., Malaver, E., Torres, O., Lazzari, M.A., Gomez, R.M. Schattner, M. (2006) Activation of cyclic AMP pathway prevents CD34(+) cell apoptosis. Experimental Hematology, 34, 1420 1428.
8. O'Brien, J.J., Spinelli, S.L., Tober, J., Blumberg, N., Francis, C.W., Taubman, M.B., Palis, J., Seweryniak, K.E., Gertz, J.M. Phipps, R.P. (2008) 15-deoxy-delta12,14-PGJ2 enhances platelet production from megakaryocytes. Blood, 112, 4051 4060.
9. Ray, D.M., Akbiyik, F. Phipps, R.P. (2006) The peroxisome proliferator-activated receptor gamma (PPARgamma) ligands 15-deoxy-Delta12,14- prostaglandin J2 and ciglitazone induce human B lymphocyte and B cell lymphoma apoptosis by PPARgamma-independent mechanisms. The Journal of Immunology, 177, 5068 5076.
10. Takano, H. Komuro, I. (2009) Peroxisome proliferator-activated receptor gamma and cardiovascular diseases. Circulation Journal, 73, 214 220.