Solid phase synthesis of novel asymmetric hydrophilic head cholesterol-based cationic lipids with potential DNA delivery

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 1, 2010, Pages 330-342

  Radchatawedchakoon, Widchaya ^a   Watanapokasin, Ramida ^b   Krajarng, Aungkana ^b   Yingyongnarongkul, Boon ek ^a  

^a RAMKHAMHAENG UNIVERSITY   (Thailand)

^b SRINAKHARINWIROT UNIVERSITY   (Thailand)

Author keywords

Cationic lipids; Cholesterol based; DNA delivery; Liposomes; Non viral vector; Solid phase synthesis; Transfection

Indexed keywords

3B [N [N',N' DI(2'' HYDROXYETHYL) 2' AMINOETHYL] N [N GLYCINE[N (2 AMINOETHYL)AMIDE]]CARBAMOYL]CHOLESTEROL; 3BETA [N (2' AMINOETHYL) N [N GLYCINE[N (2 AMINOETHYL)AMIDE]]CARBAMOYL]CHOLESTEROL; 3BETA [N (2' AMINOETHYL) N [N GLYCINE[N (3 AMINOPROPYL) AMIDE]]CARBAMOYL]CHOLESTEROL; 3BETA [N (3' AMINOPROPYL) N [N GLYCINE[N (2 AMINOETHYL) AMIDE]]CARBAMOYL]CHOLESTEROL; 3BETA [N (3' AMINOPROPYL) N [N GLYCINE[N (3 AMINOPROPYL) AMIDE]]CARBAMOYL]CHOLESTEROL; 3BETA [N (N' GUANIDINYL 2' AMINOETHYL) N [N GLYCINE[N (2 AMINOETHYL)AMIDE]]CARBAMOYL]CHOLESTEROL; 3BETA [N (N' GUANIDINYL 2' AMINOETHYL) N [N GLYCINE[N (3 AMINOPROPYL)AMIDE]]CARBAMOYL]CHOLESTEROL; 3BETA [N (N' GUANIDINYL 3' AMINOPROPYL) N [N GLYCINE [N (3 AMINOPROPYL)AMIDE]]CARBAMOYL]CHOLESTEROL; 3BETA [N (N' GUANIDINYL 3' AMINOPROPYL) N [N GLYCINE[N (2 AMINOETHYL)AMIDE]] CARBAMOYL]CHOLESTEROL; 3BETA [N (N' GUANIDINYL) 2' AMINOETHYL N (2 AMINOETHYL)CARBAMOYL]CHOLESTEROL; 3BETA [N (N',N' DI(2'' HYDROXYETHYL) 3' AMINOPROPYL) N (3 AMINOPROPYL)CARBAMOYL]CHOLESTEROL; 3BETA [N [(N' GUANIDINYL) 2' AMINOETHYL] N (2 AMINOETHYL) CARBAMOYL]CHOLESTEROL; 3BETA [N [(N' GUANIDINYL) 3' AMINOPROPYL] N (3 AMINOPROYL)CARBAMOYL]CHOLESTEROL; 3BETA [N [(N',N',N' TRIMETHYL) 2' AMINOETHYL] N (2 AMINO ETHYL)CARBAMOYL]CHOLESTEROL; 3BETA [N [(N',N',N' TRIMETHYL) 2' AMINOETHYL] N [N GLYCINE[N (2 AMINOETHYL)AMIDE]]CARBAMOYL]CHOLESTEROL; 3BETA [N [(N',N',N' TRIMETHYL) 2' AMINOETHYL] N [N GLYCINE[N (3 AMINOPROPYL)AMIDE]]CARBAMOYL]CHOLESTEROL; 3BETA [N [(N',N',N' TRIMETHYL) 3' AMINOPROPYL] N (3 AMINOPROPYL)CARBAMOYL]CHOLESTEROL; 3BETA [N [(N',N',N' TRIMETHYL) 3' AMINOPROPYL] N [N GLYCINE [N (2 AMINOETHYL)AMIDE]]CARBAMOYL]CHOLESTEROL; 3BETA [N [(N',N',N' TRIMETHYL) 3' AMINOPROPYL] N [N GLYCINE [N (3 AMINOPROPYL)AMIDE]]CARBAMOYL] CHOLESTEROL; 3BETA [N [N',N' DI(2'' HYDROXYETHYL) 2' AMINOETHYL] N (2 AMINOETHYL)CARBAMOYL]CHOLESTEROL; 3BETA [N [N',N' DI(2'' HYDROXYETHYL) 2' AMINOETHYL] N [N GLYCINE[N (3 AMINOPROPYL)AMIDE]]CARBAMOYL]CHOLESTEROL; 3BETA [N [N',N' DI(2'' HYDROXYETHYL) 3' AMINOPROPYL] N [N GLYCINE[N (2 AMINOETHYL)AMIDE]]CARBAMOYL]CHOLESTEROL; 3BETA [N [N',N' DI(2'' HYDROXYETHYL) 3' AMINOPROPYL] N [N GLYCINE[N (3 AMINOPROPYL)AMIDE]]CARBAMOYL]CHOLESTEROL; 3BETA [N,N (2,2' DIAMINOETHYL)CARBAMOYL]CHOLESTEROL; 3BETA [N,N (3,3' DIAMINOPROPYL)CARBAMOYL]CHOLESTEROL; CHOLESTEROL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DNA BINDING; DNA TRANSFECTION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; GENE TARGETING; HUMAN; HUMAN CELL; PROSTATE ADENOCARCINOMA; PROTON NUCLEAR MAGNETIC RESONANCE; SOLID PHASE SYNTHESIS; TRANSMISSION ELECTRON MICROSCOPY;

BINDING SITES; CATIONS; CELL LINE; CELL LINE, TUMOR; CHOLESTEROL; DNA; HUMANS; LIPIDS; LIPOSOMES; PHOSPHATIDYLETHANOLAMINES; SERUM; TRANSFECTION;

EID: 72149112492     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.10.057     Document Type: Article

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