The protective effects of chloride channel blockers on the cultured hippocampal neuronal apoptosis induced by NO in rats

Chinese Pharmacological Bulletin

Volumn 25, Issue 9, 2009, Pages

  Chang, Quan Zhong ^a   Zhang, Shu Ling ^a   Yin, Jin Bao ^a   Cai, Shi Ning ^a  

^a ZUNYI MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Caspase 3; Chloride channel blocker; Hippocampal neuron; NO; Rat

Indexed keywords

4 ACETAMIDO 4' ISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; CASPASE 3; CHLORIDE CHANNEL BLOCKING AGENT; NITRIC OXIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; HIPPOCAMPUS; NERVE CELL LESION; NONHUMAN; RAT; STAINING; WESTERN BLOTTING;

EID: 72149108403     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Lang F, Lang K S, Wieder T, et al. Cation channels, cell volume and the death of an erythrocyte[J]. Pflugers Arch, 2001,447:121-125
2. Chen J, Liu D, Chen H P. Study the mechanism of chloride on the participating in the myocardiac hypoxia-reperfusion injury [J]. Chin Pharmacol Bull, 2007,23(6):724-729
3. 50-values and cell survival[J]. Eur J Chem Clin Biochem, 1995,33(11):813-823
4. Albrecht L W, Szabo I, Wieland U, et al. Tyrosine kinases open lymphocyte chloride channels [J]. Cell Physiol Biochem, 2000,10:307-312
5. Gao M Q, Guo S B, Chen X H, et al. Molecular mechanisms of polypeptide from Chlamys farreri protecting HaCaT cells from apoptosis induced by UVA plus UVB[J]. Acta Pharmacol Sin, 2007,28(7):1007-1014
6. Trackey J L, Uliasz T F, Hewett S. SIN-1-induced cytotoxicity in mixed cortical cell culture: peroxynitrite-dependent and independent induction of excitotoxic cell death [J]. J Neurochem, 2001,79:445-455 (Pubitemid 32988961)
7. Chang Q Z, Zhang S L. The effect of estrogen on the cultured hippocampal neuronal apoptosis induced by NMDA in rat [J]. Chin Pharmacol Bull, 2006,22(4):456-459
8. Schulz J B, Weller M, Mathewes R T,et al. Expended therapeutic window for caspase inhibition and synegy with MK-801 in the treatment of cerebralk histotoxic hypoxia[J]. Cell Death Differ, 1999,5:843-857