Effect of estrone on hippocampal neuronal apoptosis induced by NMDA in rat primary culture

Chinese Pharmacological Bulletin

Volumn 22, Issue 4, 2006, Pages 456-460

  Chang, Quan Zhong ^a   Zhang, Shu Ling ^a  

^a XINXIANG MEDICAL UNIVERSITY   (China)

Author keywords

Caspase 3; Estrone; Hippocampal neuron; Neuronal apoptosis; NMDA

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; CASPASE 3; ESTRONE; FLUORESCENT DYE; GLYCINE; N METHYL DEXTRO ASPARTIC ACID;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVITY; HIPPOCAMPUS; IN VITRO STUDY; MORPHOLOGY; NERVE CELL; NEUROPROTECTION; NONHUMAN; RAT; WESTERN BLOTTING;

EID: 33745460852     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Garcica-Segura L M, Azcoitia I, DonCarlos L L. Neuroprotection by estradiol[J]. Prog Neurobiol, 2001, 63(1):29-60.
2. Shughrue P J, Merchenthaler I. Estrogen prevents the loss of CA1 hippocampal neurons in gerbils after ischemic injury[J]. Neuroscience, 2003, 116(3):851-61.
3. Murphy S J, Traystman R J, Hurn PD, et al. Progesterone exacerbates stratal stroke injury in progesterone deficicent female animals [J]. Stroke, 2000, 31(5):1173-8.
4. Ma X C, Gottschall P E, Chen L T, et al. Role and mechanisms of Interleukin-1 in the modulation of neurotoxicity[J]. Neuroimmunomodulation, 2003, 10(4):199-207.
5. Wang C, Kaufmann J A, Sanchez-Ross M G, Johnson K M. Mechanisms of N-methyl-D-asparate-induced apoptosis phencyclidine-treated cultured forebrain neurons[J]. J Pharmacol Exp Ther, 2000, 294(1):287-95.
6. Pi R, Li W, Lee NT, et al. Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways[J]. J Neurochem, 2004, 91(5): 1219-30.
7. Bossenmeyer P C, Koziel V, Daval J L. Hypoxia/reoxygenation induces apoptosis through biphasic induction of protein synthesis in cultured rat brain neurons[J]. Neuroscience, 2000, 95(4):1157-65.
8. 50 values and cell survival[J]. Eur J Chem Clin Biochem, 1995, 33(11):813-23.
9. Kajta M, Lason W, Bien E, et al. Neuroprotective effect of estrone on NMDA-induced toxicity in primary cultures of rat cortical neurons are independent of estrogen receptors[J]. Pol J Pharmacol, 2002, 54(6):727-9.
10. Lesort M, Esclaire F, Yardin C, et al. NMDA induces apoptosis and necrosis in neuronal cultures. Increased APP immunoreactivity is linked to apoptotic cells[J]. Neurosci Lett, 1997, 221(2-3): 213-6.
11. Weaver C E, Park-Chung M, Gibbs T T, et al. 17β-estradiol protects against NMDA-induced excitotoxity by direct inhibition of NMDA receptors[J]. Brain Res, 1997, 761:339-41.
12. 2+]i during metabolic inhibition[J]. J Mol Cell Cardiol, 2003, 35(3):331-6.
13. Kerohn A J, Preis E, Prehn JHM. Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1 -like protease as upstream inhibitors and increased production of siperoxide as main downstream effector[J]. J Neurosci, 1998, 18:8186-97.
14. Maier J K, Lahoua Z, Gendron NH, et al. The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7[J]. J Neurosci, 2002, 22(6):2035-43.
15. Cohen G M. Caspases: The executioners of apoptosis[J]. Biochem J, 1997, 326:1-16.
16. Shughrue P J, Merchenthaler I. Estrogen prevents the loss of CA1 hippocampal neurons in gerbils after ischemic injury[J]. Neuroscience, 2003, 116(3):851-61.