Gabapentin treatment improves motor coordination in a mice model of progressive ataxia

Brain Research

Volumn 1301, Issue , 2009, Pages 135-142

  Massella, Alessandro ^a   Gusciglio, Marco ^b   D'Intino, Giulia ^a   Sivilia, Sandra ^a   Ferraro, Luca ^c   Calzà, Laura ^a   Giardino, Luciana ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b IRET Foundation   (Italy)

^c UNIVERSITY OF FERRARA   (Italy)

Author keywords

Ataxia; GABA content; Gabapentin; HCN1 mice

Indexed keywords

4 AMINOBUTYRIC ACID; GABAPENTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; CELL COMPOSITION; CEREBELLUM CORTEX; CEREBELLUM DEGENERATION; CONTROLLED STUDY; MALE; MOTOR COORDINATION; MOTOR PERFORMANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ROTAROD TEST;

AGE FACTORS; AMINES; ANALYSIS OF VARIANCE; ANIMALS; ATAXIA; ATROPHY; CELL COUNT; CEREBELLUM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; CYCLOHEXANECARBOXYLIC ACIDS; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE; MICE; MICE, KNOCKOUT; MOTOR SKILLS; POTASSIUM CHANNELS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; ROTAROD PERFORMANCE TEST; STAINING AND LABELING;

MUS;

EID: 72149107369     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2009.09.004     Document Type: Article

References (38)

1. Albin R.L. Dominant ataxias and Friedreich ataxia: an update. Curr. Opin. Neurol. 16 (2003) 507-514
2. Bender R.A., Galindo R., Mameli M., Gonzalez-Vega R., Valenzuela C.F., and Baram T.Z. Synchronized network activity in developing rat hippocampus involves regional hyperpolarization-activated cyclic nucleotide-gated (HCN) channel function. Eur. J. Neurosci. 22 (2005) 2669-2674
3. Boyes J., Bolam J.P., Shigemoto R., and Stanford I.M. Functional presynaptic HCN channels in the rat globus pallidus. Eur. J. Neurosci. 25 (2007) 2081-2092
4. Bretschneider F., Wrisch A., Lehmann-Horn F., and Grissmer S. Expression in mammalian cells and electrophysiological characterization of two mutant Kv1.1 channels causing episodic ataxia type 1 (EA-1). Eur. J. Neurosci. 11 (1999) 2403-2412
5. Brunberg J.A. Ataxia. Am. J. Neuroradiol. 29 (2008) 1420-1422
6. Bulone D., Masino L., Thomas D.J., San Biagio P.L., and Pastore A. The interplay between PolyQ and protein context delays aggregation by forming a reservoir of protofibrils. PLoS ONE 1 (2006) e111
7. Crawley J.N. What's Wrong with my Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice. Second Edition (2000), John Wiley & Sons, Inc., New York
8. D'Adamo M.C., Imbrici P., Sponcichetti F., and Pessia M. Mutations in the KCNA1 gene associated with episodic ataxia type-1 syndrome impair heteromeric voltage-gated K(+) channel function. FASEB J. 13 (1999) 1335-1345
9. De Michele G., Coppola G., Cocozza S., and Filla A. A pathogenetic classification of hereditary ataxias: is the time ripe?. J. Neurol. 251 (2004) 913-922
10. Gamache P., Ryan E., Svendsen C., Murayama K., and Acworth I.N. Simultaneous measurement of monoamines, metabolites and amino acids in brain tissue and microdialysis perfusates. J. Chromatogr. 614 (1993) 213-220
11. Gazulla J., Errea J.M., Benavente I., and Tordesillas C.J. Treatment of ataxia in cortical cerebellar atrophy with the GABAergic drug gabapentin. A preliminary study. Eur. Neurol. 52 (2004) 7-11
12. Ge Y. Multiple sclerosis: the role of MR imaging. Am. J. Neuroradiol. 27 (2006) 1165-1176
13. Gidalevitz T., Ben-Zvi A., Ho K.H., Brignull H.R., and Morimoto R.I. Progressive disruption of cellular protein folding in models of polyglutamine diseases. Science 311 (2006) 1471-1474
14. Herculano-Houzel S., and Lent R. Isotropic fractionator: a simple, rapid method for the quantification of total cell and neuron numbers in the brain. J. Neurosci. 25 (2005) 2518-2521
15. Herrmann S., Stieber J., and Ludwig A. Pathophysiology of HCN channels. Pflugers Arch. 454 (2007) 517-522
16. Holderith N.B., Shigemoto R., and Nusser Z. Cell type-dependent expression of HCN1 in the main olfactory bulb. Eur. J. Neurosci. 18 (2003) 344-354
17. Kanazawa I., Kwak S., Sasaki H., Mizusawa H., Muramoto O., Yoshizawa K., Nukina N., Kitamura K., Kurisaki H., and Sugita K. Studies on neurotransmitter markers and neuronal cell density in the cerebellar system in olivopontocerebellar atrophy and cortical cerebellar atrophy. J. Neurol. Sci. 71 (1985) 193-208
18. Jen J., Wan J., Graves M., Yu H., Mock A.F., Coulin C.J., Kim G., Yue Q., Papazian D.M., and Baloh R.W. Loss-of-function EA2 mutations are associated with impaired neuromuscular transmission. Neurology 57 (2001) 1843-1848
19. Lado F.A., Sperber E.F., and Moshé S.L. Anticonvulsant efficacy of gabapentin on kindling in the immature brain. Epilepsia 42 (2001) 458-463
20. Leret M.L., Lecumberri M., Garcia-Montojo M., and González J.C. Role of maternal corticosterone in the development and maturation of the aminoacidergic systems of the rat brain. Int. J. Dev. Neurosci. 25 (2007) 465-471
21. Nakamura K., Yoshida K., Miyazaki D., Morita H., and Ikeda S. Spinocerebellar ataxia type 6 (SCA6): Clinical pilot trial with gabapentin. J. Neurol. Sci. 278 (2009) 107-111
22. Nolan M.F., Malleret G., Lee K.H., Gibbs E., Dudman J.T., Santoro B., Yin D., Thompson R.F., Siegelbaum S.A., Kandel E.R., and Morozov A. The hyperpolarization-activated HCN1 channel is important for motor learning and neuronal integration by cerebellar Purkinje cells. Cell 115 (2003) 551-564
23. Nolan M.F., Malleret G., Dudman J.T., Buhl D.L., Santoro B., Gibbs E., Vronskaya S., Buzsáki G., Siegelbaum S.A., Kandel E.R., and Morozov A. A behavioral role for dendritic integration: HCN1 channels constrain spatial memory and plasticity at input to distal dendrites of CA1 pyramidal neurons. Cell 119 (2004) 719-732
24. Ohman I., Vitols S., and Tomson F. Pharmacokinetics of gabapentin during delivery, in the neonatal period, and lactation: does a fetal accumulation occur during pregnancy?. Epilepsia 46 (2005) 1621-1624
25. Perlman S.L. Symptomatic and disease-modifying therapy for the progressive ataxias. Neurologist 10 (2004) 275-289
26. Ramsay R.E. Gabapentin: adverse effects. In: Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds). Antiepileptic Drugs. 5th ed. (2002), Lippincott Williams & Wilkins, Philadelphia 354-360
27. Robinson R.B., and Siegelbaum S.A. Hyperpolarization-activated cation currents: from molecules to physiological function. Annu. Rev. Physiol. 65 (2003) 453-480
28. Sastry B.R., Morishita W., Yip S., and Shew T. GABA-ergic transmission in deep cerebellar nuclei. Prog. Neurobiol. 53 (1997) 259-271
29. Schmitz-Hübsch T., and Klockgether T. An update on inherited ataxias. Curr. Neurol. Neurosci. Rep. 8 (2008) 310-319
30. Sills G.J. The mechanisms of action of gabapentin and pregabalin. Curr. Opin. Pharmacol. 6 (2006) 108-113
31. Sommer B.R., Fenn H.H., and Ketter T.A. Safety and efficacy of anticonvulsants in elderly patients with psychiatric disorders: oxcarbazepine, topiramate and gabapentin. Expert Opin. Drug Saf. 6 (2007) 133-145
32. Soong B.W., and Paulson H.L. Spinocerebellar ataxias: an update. Curr. Opin. Neurol. 20 (2007) 438-446
33. Sultan F., König T., Möck M., and Their P. Quantitative organization of neurotransmitters in the deep cerebellar nuclei of the Lurcher mutant. J. Comp. Neurol. 452 (2002) 311-323
34. Taylor C.P. Mechanisms of action of gabapentin. Rev. Neurol. (Paris) 153 Suppl. 1 (1997) S39-S45
35. Taylor C.P., Gee N.S., Su T.-Z., Kcsis J.-D., Welty D.-F., Brown J.P., Dooley D.J., Boden P., and Singh L. A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res. 29 (1998) 233-249
36. Varga V., Hangya B., Kránitz K., Ludányi A., Zemankovics R., Katona I., Shigemoto R., Freund T.F., and Borhegyi Z. The presence of pacemaker HCN channels identifies theta rhythmic GABAergic neurons in the medial septum. J. Physiol. 586 (2008) 3893-3915
37. Wells R.D. DNA triplexes and Friedreich ataxia. FASEB J 22 (2008) 1625-1634
38. Young L.T., Robb J.C., Hasey G.M., MacQueen G.M., Patelis Siotis I., Marriott M., and Joffe R.T. Gabapentin as an adjunctive treatment in bipolar disorder. J. Affect. Disord. 55 (1999) 73-77