In vitro cytotoxicity and drug release properties of pH- and temperature-sensitive core-shell hydrogel microspheres

International Journal of Pharmaceutics

Volumn 385, Issue 1-2, 2010, Pages 86-91

  Ma, Liwei ^a   Liu, Mingzhu ^a   Liu, Hongliang ^a   Chen, Jun ^a   Cui, Dapeng ^a  

^a LANZHOU UNIVERSITY   (China)

Author keywords

Controlled release; Core shell; Hydrogel microspheres; pH and temperature sensitive

Indexed keywords

BOVINE SERUM ALBUMIN; COPOLYMER; DRUG CARRIER; MICROSPHERE; POLY(N,N DIETHYLACRYLAMIDE CO METHACRYLIC ACID); POLYMETHACRYLIC ACID DERIVATIVE; SURFACTANT; UNCLASSIFIED DRUG; WATER;

ARTICLE; BIOCOMPATIBILITY; CELL ASSAY; CHEMICAL COMPOSITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG RELEASE; EMULSION; ENCAPSULATION; HELA CELL; HUMAN; HUMAN CELL; HYDROGEL; IN VITRO STUDY; INFRARED SPECTROSCOPY; LIGHT SCATTERING; PARTICLE SIZE; PH; POLYMERIZATION; PRIORITY JOURNAL; TEMPERATURE SENSITIVITY; TRANSMISSION ELECTRON MICROSCOPY; ULTRAVIOLET SPECTROSCOPY;

ACRYLAMIDES; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DIFFUSION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; HELA CELLS; HUMANS; HYDROGELS; HYDROGEN-ION CONCENTRATION; HYDROPHOBICITY; KINETICS; LIGHT; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSPHERES; MODELS, CHEMICAL; POLYMERS; POLYMETHACRYLIC ACIDS; SCATTERING, RADIATION; SERUM ALBUMIN, BOVINE; SOLUBILITY; SOLVENTS; SPECTROPHOTOMETRY, ULTRAVIOLET; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; WATER;

EID: 72149106156     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.10.037     Document Type: Article

References (35)

1. Antonietti M., Pakula T., and Bremser W. Rheology of small spherical polystyrene microgels: a direct proof for a new transport mechanism in bulk polymers besides reptation. Macromolecules 28 (1995) 4227-4233
2. Bergbreiter D.E., Case B.L., Liu Y.S., and Caraway J.W. Poly(N-isopropylacrylamide) soluble polymer supports in catalysis and synthesis. Macromolecules 31 (1998) 6053-6062
3. Berkland C., Cox A., Kim K.K., and Pack D.W. Three-month, zero-order piroxicam release from monodispersed double-walled microspheres of controlled shell thickness. J. Biomed. Mater. Res. 70A (2004) 576-584
4. Chai Z.K., Zheng X., and Sun X.F. Preparation of polymer microspheres from solutions. J. Polym. Sci. B: Polym. Phys. 41 (2003) 159-165
5. Chen X., Cui Z.C., Chen Z.M., Zhang K., Lu G., Zhang G., and Yang B. The synthesis and characterizations of monodisperse cross-linked polymer microspheres with carboxyl on the surface. Polymer 43 (2002) 4147-4152
6. Gao C.M., Liu M.Z., Chen S.L., Jin S.P., and Chen J. Preparation of oxidized sodium alginate-graft-poly((2-dimethylamino) ethyl methacrylate) gel beads and in vitro controlled release behavior of BSA. Int. J. Pharm. 371 (2009) 16-24
7. Guiseppi-Elie A., Sheppard N.F., Brahim S., and Narinesingh D. Enzyme microgels in packed-bed bioreactors with downstream amperometric detection using microfabricated interdigitated microsensor electrode arrays. Biotechnol. Bioeng. 75 (2001) 475-484
8. Ichikawa H., and Fukumori Y. A novel positively thermosensitive controlled-release microcapsule with membrane of nano-sized poly(N-isopropylacrylamide) gel dispersed in ethylcellulose matrix. J. Control. Release 63 (2000) 107-119
9. Irene B., Catherine D., and Patrick C. Nanoparticles in cancer therapy and diagnosis. Adv. Drug Deliv. Rev. 54 (2002) 631-651
10. Jones C.D., and Lyon L.A. Synthesis and characterization of multiresponsive core-shell microgels. Macromolecules 33 (2000) 8301-8306
11. Jones C.D., and Lyon L.A. Shell-restricted swelling and core compression in poly(N-isopropylacrylamide) core-shell microgels. Macromolecules 36 (2003) 1988-1993
12. Kawaguchi H., and Fujimoto K. Smart latexes for bioseparation. Bioseparation 7 (1998) 253-258
13. Kima J.W., Leeb J.E., Kima S.J., Leea J.S., Ryub J.H., Kima J., Hana S.H., Changa I.S., and Suh K.D. Synthesis of silver/polymer colloidal composites from surface-functional porous polymer microspheres. Polymer 45 (2004) 4741-4747
14. Kimura K., Kohama S., Yamashita Y., Uchida T., and Sakaguchi Y. Diameter control of poly(p-oxycinnamoyl) microspheres prepared by self-organizing polycondensation. Polymer 44 (2003) 7383-7387
15. Lee I.S., Cho M.S., and Choi H.J. Preparation of polyaniline coated poly(methyl methacrylate) microsphere by graft polymerization and its electrorheology. Polymer 46 (2005) 1317-1321
16. Lee T.H., Wang J., and Wang C.H. Double-walled microspheres for the sustained release of a highly water soluble drug: characterization and irradiation studies. J. Control. Release 83 (2002) 437-452
17. Leobandung W., Ichikawa H., Fukumori Y., and Peppas N.A. Monodisperse nanoparticles of poly(ethylene glycol) macromers and N-isopropyl acrylamide for biomedical applications. J. Appl. Polym. Sci. 87 (2003) 1678-1684
18. Leung M.F., Zhu J., Harris F.W., and Li P. New route to smart core-shell polymeric microgels: synthesis and properties. Macromol. Rapid Commun. 25 (2004) 1819-1823
19. Li X., Wu Q., Chen Z.C., Gong X.G., and Lin X.F. Preparation, characterization and controlled release of liver-targeting nanoparticles from the amphiphilic random copolymer. Polymer 49 (2008) 4769-4775
20. Liu G.Y., Zhai Y.L., Wang X.L., Wang W.T., Pan Y.B., Dong X.T., and Wang Y.Z. Preparation, characterization, and in vitro drug release behavior of biodegradable chitosan-graft-poly(1,4-dioxan-2-one) copolymer. Carbohydr. Polym. 74 (2008) 862-867
21. Liu H.L., Liu M.Z., Jin S.P., and Chen S.L. Synthesis and characterization of fast responsive thermo- and pH-sensitive poly[(N,N-diethylacrylamide)-co-(acrylic acid)] hydrogels. Polym. Int. 57 (2008) 1165-1173
22. Marilia P., and Ruth F. Synthesis and characterisation of stimuli-responsive poly(N,N′-diethylacrylamide) hydrogels. Polymer 46 (2005) 615-621
23. Neyret S., and Vincent B. The properties of polyampholyte microgel particles prepared by microemulsion polymerization. Polymer 38 (1997) 6129-6134
24. Öle Kiminta D.M., Luckham P.F., and Lenon S. The rheology of deformable and the responsive microgel particles. Polymer 36 (1995) 4827-4831
25. Panayiotou M., Pöhner C., Vandevyver C., Wandrey C., Hilbrig F., and Freitag R. Synthesis and characterisation of thermo-responsive poly(N,N-diethylacrylamide) microgels. React. Funct. Polym. 67 (2007) 807-819
26. Panchapakesan B., DeVoe D.L., Widmaier M.R., Cavicchi R., and Semancik S. Nanoparticle engineering and control of tin oxide microstructures for chemical microsensor applications. Nanotechnology 12 (2001) 336-349
27. Ramesh Babu V., Hosamani K.M., and Aminabhavi T.M. Preparation and in-vitro release of chlorothiazide novel pH-sensitive chitosan-N,N′-dimethylacrylamide semi-interpenetrating network microspheres. Carbohydr. Polym. 71 (2008) 208-217
28. Ritger P.L., and Peppas N.A. A simple equation for description of solute release. II Fickian and anomalous release from swellable devices. J. Control. Release 5 (1987) 37-42
29. Shibanuma T., Aoki T., Sanui K., Ogata N., Kikuchi A., Sakurai Y., and Okano T. Thermosensitive phase-separation behavior of poly(acrylic acid)-graft-poly(N,N-dimethylacrylamide) aqueous solution. Macromolecules 33 (2000) 444-450
30. Vihola H., Laukkanen A., Hirvonen J., and Tenhu H. Binding and release of drugs into and from thermosensitive poly(N-vinyl caprolactam) nanoparticles. Eur. J. Pharm. Sci. 16 (2002) 69-74
31. Wu C., and Zhou S.Q. Effects of surfactants on the phase transition of poly(N-isopropylacrylamide) in water. J. Polym. Sci. B: Polym. Phys. 34 (1996) 1597-1604
32. Wu X., Pelton R.H., Hamielec A.E., Woods D.R., and McPhee W. The kinetics of poly(N-isopropylacrylamide) microgel latex formation. Colloid Polym. Sci. 272 (1994) 467-477
33. Xiao X.C., Chu L.Y., Chen W.M., Wang S., and Xie R. Preparation of submicrometer-sized monodispersed thermoresponsive core-shell hydrogel microspheres. Langmuir 20 (2004) 5247-5253
34. Yang Y.Y., Shi M., Goh S.H., Moochhala S.M., Ng S., and Heller J. POE/PLGA composite microspheres: formation and in vitro behavior of double walled microspheres. J. Control. Release 88 (2003) 201-213
35. Zhang X.Z., Zhuo R.X., and Yang Y.Y. Using mixed solvent to synthesize temperature sensitive poly(N-isopropylacrylamide) gel with rapid dynamics properties. Biomaterials 23 (2002) 1313-1318