Automated assays for sVEGF R1 and PlGF as an aid in the diagnosis of preterm preeclampsia: a prospective clinical study

American Journal of Obstetrics and Gynecology

Volumn 202, Issue 1, 2010, Pages 40.e1-40.e7

  Sunderji, Shiraz ^a   Gaziano, Emanuel ^b   Wothe, Donald ^b   Rogers, Linda C ^c   Sibai, Baha ^d   Karumanchi, S Ananth ^e   Hodges Savola, Cheryl ^c  

^a TOLEDO HOSPITAL   (United States)

^b ABBOTT NORTHWESTERN HOSPITAL   (United States)

^c Beckman Coulter Inc   (United States)

^d UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

angiogenesis; biomarkers; hypertensive disorders of pregnancy; PlGF; preeclampsia; sFlt1; sVEGF R1

Indexed keywords

PLACENTAL GROWTH FACTOR; VASCULOTROPIN RECEPTOR 1;

ADULT; ARTICLE; AUTOANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HYPERTENSION; PREECLAMPSIA; PRIORITY JOURNAL;

EID: 72149103278     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2009.07.025     Document Type: Article

References (20)

1. 2000 Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol 183 (2000) S1-S22
2. Walker J.J. Pre-eclampsia. Lancet 356 (2000) 1260-1265
3. Chang J., Elam-Evans L.D., Berg C.J., et al. Pregnancy-related mortality surveillance-United States, 1991-1999. Mor Mortal Wkly Rep CDC Surveill Summ 52 (2003) (No. SS-2)
4. Sibai B., Dekker G., and Kupferminc M. Pre-eclampsia. Lancet 365 (2005) 785-799
5. Matter F., and Sibai B. Eclampsia VIII. Risk factors for maternal morbidity. Am J Obstet Gynecol 182 (2000) 307-312
6. Redman C.W., and Sargent I.L. Latest advances in understanding preeclampsia. Science 308 (2005) 1502-1504
7. Sibai B.M., and Barton J.R. Expectant management of severe preeclampsia remote from term: patient selection, treatment, and delivery indications. Am J Obstet Gynecol 196 (2007) 514.e1-514.e9
8. Thadhani R., Mutter W.P., Wolf M., et al. First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia. J Clin Endocrinol Metab 89 (2004) 770-775
9. Levine R.J., Maynard S.E., Qian C., et al. Circulating angiogenic factors and the risk for preeclampsia. N Engl J Med 350 (2004) 672-683
10. Bersinger N.A., and Odegard R.A. Second- and third-trimester serum levels of placental proteins in preeclampsia and small-for-gestational age pregnancies. Acta Obstet Gynecol Scand 83 (2004) 37-45
11. McKeeman G.C., Ardill J.E.S., Caldwell C.M., Hunter A.J., and McClure N. Soluble vascular endothelial growth factor receptor-1 (VEGF R-1) is increased throughout gestation in patients who have preeclampsia develop. Am J Obstet Gynecol 191 (2004) 1240-1246
12. Krauss T., Pauer H.U., and Augustin H.G. Prospective analysis of placental growth factor (PlGF) concentrations in the plasma of women with normal pregnancy and pregnancies complicated by preeclampsia. Hypertens Pregnancy 23 (2004) 101-111
13. Romero R., Nien J.K., Espinoza J., et al. A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop Preeclampsia and deliver a small for gestational age neonate. J Matern Fetal Neonatal Med 21 (2008) 9-23
14. Salahuddin S., Lee Y., Vadnais M., Sachs B.P., Karumanchi S.A., and Lim K. Diagnostic utility of soluble fms-like tyrosine kinase 1 and soluble endoglin in hypertensive diseases of pregnancy. Am J Obstet Gynecol 197 (2007) 28.e1-28.e6
15. Buhimschi C.S., Norwitz E.R., Funai E., et al. Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia. Am J Obstet Gynecol 192 (2005) 734-741
16. Levine R.J., Lam C., Qian C., et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 355 (2006) 992-1005
17. American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 33. Clinical management guidelines for obstetrician-gynecologists (January 2002) Washington, DC
18. Lam C., Lim K., and Karumanchi S.A. Circulating angiogenic factors in the pathogenesis and prediction of preeclampsia. Hypertension 46 (2005) 1077-1085
19. Wothe D., Gaziano E., Sunderji S., et al. Evaluation of angiogenic and anti-angiogenic proteins in serum: comparing the performance of ELISA assays for sVEGF R1 and PlGF from R&D Systems with optimized prototype sVEGF R1 and PlGF assays from Beckman Coulter. Hypertens Pregnancy (2009) (Submitted)
20. Valensise H., Vasapollo B., Novelli G.P., Pasqualetti P., Galante A., and Arduini D. Maternal total vascular resistance and concentric geometry: a key to identify compicated gestational hypertension. BJOG 113 (2006) 1044-1052