Liquid chromatography-tandem mass spectrometry method for the quantification of dimebon in rat plasma and brain tissue

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 29, 2009, Pages 3563-3571

  Nirogi, Ramakrishna ^a   Kandikere, Vishwottam ^a   Mudigonda, Koteshwara ^a   Komarneni, Prashanth ^a   Boggavarapu, Rajeshkumar ^a  

^a SUVEN LIFE SCIENCES LTD   (India)

Author keywords

Brain tissue; Clinical trials; Dimebon; Liquid chromatography tandem mass spectrometry; Plasma

Indexed keywords

ANALYTES; ASSAY METHODS; BRAIN TISSUE; CLINICAL TRIAL; DIMEBON; HUMAN PLASMAS; INTERNAL STANDARDS; LINEAR DYNAMIC RANGES; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID-LIQUID EXTRACTION; MOBILE PHASE; MULTIPLE-REACTION MONITORING MODES; PHARMACOKINETIC STUDIES; RAT PLASMA; REVERSED-PHASE COLUMNS; RUNTIMES; STANDARD CURVES;

BRAIN; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; PLASMA (HUMAN); PLASMAS; SOLVENT EXTRACTION; TISSUE;

HIGH PRESSURE LIQUID CHROMATOGRAPHY;

CARVEDILOL; DIMEBON;

ALZHEIMER DISEASE; ANALYTIC METHOD; ARTICLE; BRAIN TISSUE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DETERMINATION; DRUG STRUCTURE; HUNTINGTON CHOREA; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY;

ANIMALS; BRAIN; CHROMATOGRAPHY, LIQUID; INDOLES; MOLECULAR STRUCTURE; RATS; TANDEM MASS SPECTROMETRY;

RATTUS; RODENTIA;

EID: 72149093797     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.08.042     Document Type: Article

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