ST depression at caesarean section and the relation to oxytocin dose. A randomised controlled trial

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 117, Issue 1, 2010, Pages 76-83

  Jonsson, M ^a   Hanson, U ^a   Lidell, C ^b   Norden Lindeberg S ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Caesarean section; Electrocardiography; Heart; Hypotension; Ischaemia; Oxytocin; Regional anaesthesia

Indexed keywords

CARBOPROST; EPHEDRINE; HEMOGLOBIN; OXYGEN; OXYTOCIN; PHENYLEPHRINE; TROPONIN I;

ADULT; ARTICLE; BLOOD PRESSURE; BLOOD SAMPLING; CESAREAN SECTION; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DYSPNEA; ELECTROCARDIOGRAM; FEMALE; HEART MUSCLE ISCHEMIA; HEART RATE; HOLTER MONITORING; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; MEAN ARTERIAL PRESSURE; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; SIDE EFFECT; SPINAL ANESTHESIA; ST SEGMENT DEPRESSION; SWEDEN; THORAX PAIN;

ADULT; ANESTHESIA, OBSTETRICAL; ANESTHESIA, SPINAL; ARRHYTHMIAS, CARDIAC; BLOOD PRESSURE; CESAREAN SECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ELECTROCARDIOGRAPHY, AMBULATORY; FEMALE; HUMANS; OXYTOCICS; OXYTOCIN; PREGNANCY; TROPONIN I;

EID: 72149086024     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.2009.02356.x     Document Type: Article

References (34)

1. Palmer CM, Norris MC, Giudici MC, Leighton BL, DeSimone CA. Incidence of electrocardiographic changes during Cesarean delivery under regional anesthesia. Anesth Analg 1990 70 : 36 43.
2. Mathew JP, Fleisher LA, Rinehouse JA, Sevarino FB, Sinatra RS, Nelson AH, et al. ST segment depression during labor and delivery. Anesthesiology 1992 77 : 635 641.
3. Zakowski MI, Ramanathan S, Baratta JB, Cziner D, Goldstein MJ, Kronzon I, et al. Electrocardiographic changes during cesarean section: a cause for concern? Anesth Analg 1993 76 : 162 167.
4. Moran C, Ni Bhuinneain M, Geary M, Cunningham S, McKenna P, Gardiner J. Myocardial ischaemia in normal patients undergoing elective caesarean section: a peripartum assessment. Anaesthesia 2001 56 : 1051 1058.
5. Svanstrom MC, Biber B, Hanes M, Johansson G, Naslund U, Balfors EM. Signs of myocardial ischaemia after injection of oxytocin: a randomized double-blind comparison of oxytocin and methylergometrine during caesarean section. Br J Anaesth 2008 100 : 683 689.
6. Pinder AJ, Dresner M, Calow C, Shorten GD, O'Riordan J, Johnson R. Haemodynamic changes caused by oxytocin during caesarean section under spinal anaesthesia. Int J Obstet Anesth 2002 11 : 156 159.
7. Langesaeter E, Rosseland LA, Stubhaug A. Hemodynamic effects of oxytocin during cesarean delivery. Int J Gynaecol Obstet 2006 95 : 46 7.
8. Archer TL, Knape K, Liles D, Wheeler AS, Carter B. The hemodynamics of oxytocin and other vasoactive agents during neuraxial anesthesia for cesarean delivery: findings in six cases. Int J Obstet Anesth 2008 17 : 247 254.
9. Weis FR Jr., Markello R, Mo B, Bochiechio P. Cardiovascular effects of oxytocin. Obstet Gynecol 1975 46 : 211 214.
10. Fortner CL. Effects of synthetic oxytocin with and without preservatives upon coronary blood flow in the dog. J Pharmacol Exp Ther 1969 165 : 258 266.
11. Chilvers JP, Cooper G, Wilson M. Myocardial ischaemia complicating an elective caesarean section. Anaesthesia 2003 58 : 822 823.
12. Tamhane P, O'Sullivan G, Reynolds F. Oxytocin in parturients with cardiac disease. Int J Obstet Anesth 2006 15 : 332 333. Author reply 333.
13. Munn MB, Owen J, Vincent R, Wakefield M, Chestnut DH, Hauth JC. Comparison of two oxytocin regimens to prevent uterine atony at cesarean delivery: a randomized controlled trial. Obstet Gynecol 2001 98 : 386 390.
14. Lokugamage AU, Paine M, Bassaw-Balroop K, Sullivan KR, Refaey HE, Rodeck CH. Active management of the third stage at caesarean section: a randomised controlled trial of misoprostol versus syntocinon. Aust N Z J Obstet Gynaecol 2001 41 : 411 414.
15. Bolton TJ, Randall K, Yentis SM. Effect of the confidential enquiries into maternal deaths on the use of Syntocinon at caesarean section in the UK. Anaesthesia 2003 58 : 277 279.
16. Wedisinghe L, Macleod M, Murphy DJ. Use of oxytocin to prevent haemorrhage at caesarean section - a survey of practice in the United Kingdom. Eur J Obstet Gynecol Reprod Biol 2008 137 : 27 30.
17. Thomas TA, Cooper GM. Maternal deaths from anaesthesia. An extract from Why mothers die 1997-1999, the Confidential Enquiries into Maternal Deaths in the United Kingdom. Br J Anaesth 2002 89 : 499 508.
18. TCEiMDitUK. Why mothers die 1997-1999. London : RCOG press 2001.
19. Karpati PC, Rossignol M, Pirot M, Cholley B, Vicaut E, Henry P, et al. High incidence of myocardial ischemia during postpartum hemorrhage. Anesthesiology 2004 100 : 30 6 Discussion 5A.
20. Tzivoni D, Benhorin J, Gavish A, Stern S. Holter recording during treadmill testing in assessing myocardial ischemic changes. Am J Cardiol 1985 55 : 1200 1203.
21. Lanza GA, Mascellanti M, Placentino M, Lucente M, Crea F, Maseri A. Usefulness of a third Holter lead for detection of myocardial ischemia. Am J Cardiol 1994 74 : 1216 1219.
22. Cohn PF, Kannel WB. Recognition, pathogenesis, and management options in silent coronary artery disease: introduction. Circulation 1987 75 : II1.
23. Panteghini M, Bonora R, Pagani F, Buffoli F, Cuccia C. Rapid, highly sensitive immunoassay for determination of cardiac troponin I in patients with myocardial cell damage. Clin Chem 1997 43 : 1464 1465.
24. Adams JE III., Sicard GA, Allen BT, Bridwell KH, Lenke LG, Davila-Roman VG, et al. Diagnosis of perioperative myocardial infarction with measurement of cardiac troponin I. N Engl J Med 1994 330 : 670 674.
25. Evron S, Ariely S, Agasi M, Eger G, Bukovsky I, Caspi E. Severe peripheral arteriospasm following oxytocin administration. Am J Obstet Gynecol 1986 155 : 657 658.
26. Spence A. Oxytocin during caesarean section. Anaesthesia 2002 57 : 722 723. Author reply 723.
27. Dogan R, Birdane A, Bilir A, Ekemen S, Tanriverdi B. Frequency of electrocardiographic changes indicating myocardial ischemia during elective caesarean delivery with regional and general anesthesia: detection based on continuous Holter monitoring and serum markers of ischemia. J Clin Anesth 2008 20 : 347 351.
28. Thomas JS, Koh SH, Cooper GM. Haemodynamic effects of oxytocin given as i.v. bolus or infusion on women undergoing caesarean section. Br J Anaesth 2007 98 : 116 119.
29. Rogers J, Wood J, McCandlish R, Ayers S, Truesdale A, Elbourne D. Active versus expectant management of third stage of labour: the Hinchingbrooke randomised controlled trial. Lancet 1998 351 : 693 699. (Pubitemid 28105338)
30. Nordstrom L, Fogelstam K, Fridman G, Larsson A, Rydhstroem H. Routine oxytocin in the third stage of labour: a placebo controlled randomised trial. Br J Obstet Gynaecol 1997 104 : 781 786.
31. Prendiville WJ, Elbourne D, McDonald S. Active versus expectant management in the third stage of labour. Cochrane Database Syst Rev 2000 3 : CD000007.
32. National Collaborating Centre for Women's and Children's Health. Caesarean Section. Clinical Guideline. London: RCOG Press at the Royal College of Obstetricians and Gynaecologists. 2004.
33. Carvalho JC, Balki M, Kingdom J, Windrim R. Oxytocin requirements at elective cesarean delivery: a dose-finding study. Obstet Gynecol 2004 104 : 1005 1010.
34. Sartain JB, Barry JJ, Howat PW, Mc Cormack DI, Bryant M. Intravenous oxytocin bolus of 2 units is superior to 5 units during elective Caesarean section. Br J Anaesth 2008 101 : 822 826.