Intravenous oxytocin bolus of 2 units is superior to 5 units during elective Caesarean section

British Journal of Anaesthesia

Volumn 101, Issue 6, 2008, Pages 822-826

  Sartain, J B ^a   Barry, J J ^a   Howat, P W ^a   McCormack, D I ^b   Bryant, M ^c  

^a CAIRNS BASE HOSPITAL   (Australia)

^b MATER HOSPITAL   (Australia)

^c ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

Anaesthesia, obstetric; Complications, hypotension; Uterus, oxytocin; Vomiting, nausea, anaesthetic factors

Indexed keywords

ANTIEMETIC AGENT; OXYTOCIN;

ADULT; ARTICLE; BLEEDING; BOLUS INJECTION; CARDIOVASCULAR EFFECT; CESAREAN SECTION; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG SAFETY; ELECTIVE SURGERY; EPIDURAL ANESTHESIA; FEMALE; HEART RATE; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; MEAN ARTERIAL PRESSURE; NAUSEA; OBSTETRIC ANESTHESIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SPINAL ANESTHESIA; UTERUS CONTRACTION; VOMITING;

EID: 56449120585     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aen273     Document Type: Article

References (16)

1. Thomas JS, Koh SH, Cooper GM. Haemodynamic effects of oxytocin given as i.v. bolus or infusion on women undergoing Caesarean section. Br J Anaesth 2007; 98: 116-9
2. Pinder AJ, Dresner M, Calow C, O'Riordan J, Johnson R. Haemodynamic changes caused by oxytocin during caesarean section under spinal anaesthesia. Int J Obstet Anesth 2002; 11: 156-9
3. Munn MB, Owen J, Vincent R, Wakefield M, Chestnut DH, Hauth JC. Comparison of two oxytocin regimens to prevent uterine atony at cesarean delivery: a randomized controlled trial. Obstet Gynecol 2001; 98: 386-90
4. Svanström MC, Biber B, Hanes M, Johansson G, Näslund U, Bålfors EM. Signs of myocardial ischaemia after injection of oxytocin: a randomized double-blind comparison of oxytocin and methylergometrine during Caesarean section. Br J Anaesth 2008; 100: 683-9
5. Why Mothers Die 1997-1999. Report on Confidential Enquiries into Maternal Deaths in the United Kingdom. London: RCOG Press, 2001; 134-49
6. British National Formulary, 54th Edn. London: BMJ Publishing Group Ltd and RPS Publishing, 2007; 415-6
7. Carvalho JC, Balki M, Kingdom J, Windrim R. Oxytocin requirements at elective cesarean delivery: a dose-finding study. Obstet Gynecol 2004; 104: 1005-10
8. Wedisinghe L, Macleod M, Murphy DJ. Use of oxytocin to prevent haemorrhage at caesarean section - a survey of practice in the United Kingdom. Eur J Obstet Gynecol Reprod Biol 2008; 137: 27-30
9. Ngan Kee WD, Khaw KS. Vasopressors in obstetrics: what should we be using? Curr Opin Anaesthesiol 2006; 19: 238-43
10. Secher NJ, Arnsbo P, Wallin L. Haemodynamic effects of oxytocin (syntocinon) and methyl ergometrine (methergin) on the systemic and pulmonary circulations of pregnant anaesthetized women. Acta Obstet Gynecol Scand 1978; 57: 97-103
11. Petersson M. Cardiovascular effects of oxytocin. Prog Brain Res 2002; 139: 281-8
12. Ngan Kee WD, Khaw KS, Ng FF. Comparison of phenylephrine infusion regimens for maintaining maternal blood pressure during spinal anaesthesia for Caesarean section. Br J Anaesth 2004; 92: 469-74
13. Dansereau J, Joshi AK, Helewa ME, et al. Double-blind comparison of carbetocin versus oxytocin in prevention of uterine atony after cesarean section. Am J Obstet Gynecol 1999; 180: 670-6
14. Gonser M. Labor induction and augmentation with oxytocin: pharmacokinetic considerations. Arch Gynecol Obstet 1995; 256: 63-6
15. Su LL, Chong YS, Samuel M. Oxytocin agonists for preventing postpartum haemorrhage (review). Cochrane Database Syst Rev 2007; CD005457.
16. Balki M, Ronayne M, Davies S, et al. Minimum oxytocin dose requirement after cesarean delivery for labor arrest. Obstet Gynecol 2006; 107: 45-50