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Volumn 877, Issue 31, 2009, Pages 4055-4058
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Formation of the N-methylpyridinium ether derivative of propofol to improve sensitivity, specificity and reproducibility of its detection in blood by liquid chromatography-mass spectrometry
a
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Author keywords
Derivatization; General anaesthesia; Liquid chromatography mass spectrometry; Pharmacokinetics; Propofol; Serum
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Indexed keywords
ANALYTICAL APPROACH;
ANALYTICAL CHALLENGE;
CONCENTRATION-DEPENDENT;
DERIVATIZATIONS;
DETECTION LIMITS;
DIRECT CONVERSION;
DISTRIBUTION VOLUME;
ETHER DERIVATIVES;
GENERAL ANAESTHESIA;
HALF LIVES;
HIGH ROBUSTNESS;
INTERNAL STANDARDS;
LC-MS/MS;
LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY;
MATRIX EFFECTS;
N-METHYLPYRIDINIUM;
PARENT COMPOUNDS;
PHARMACOKINETIC STUDIES;
PROPOFOL;
PROTEIN BINDING;
PROTEIN PRECIPITATION;
PYRIDINIUM;
QUANTITATION LIMITS;
REPRODUCIBILITIES;
SAMPLE PREPARATION;
SAMPLING RATES;
SOLVENT STABILITY;
TRIETHYLAMINES;
WHOLE BLOOD;
ACETONITRILE;
ANESTHESIOLOGY;
BIOCHEMISTRY;
BLOOD;
CHROMATOGRAPHIC ANALYSIS;
CHROMATOGRAPHY;
ETHERS;
LIQUIDS;
MASS SPECTROMETERS;
MASS SPECTROMETRY;
ORGANIC POLYMERS;
PHARMACOKINETICS;
PHENOLS;
PROTEINS;
STABILITY CRITERIA;
TOLUENE;
HIGH PRESSURE LIQUID CHROMATOGRAPHY;
ACETONITRILE;
N METHYLPYRIDINIUM ETHER DERIVATIVE;
PROPOFOL;
PYRIDINIUM DERIVATIVE;
SULFONIC ACID DERIVATIVE;
TRIETHYLAMINE;
UNCLASSIFIED DRUG;
ARTICLE;
DERIVATIZATION;
DRUG BLOOD LEVEL;
DRUG DISTRIBUTION;
DRUG PROTEIN BINDING;
LIQUID CHROMATOGRAPHY;
MASS SPECTROMETRY;
PRIORITY JOURNAL;
REPRODUCIBILITY;
SENSITIVITY AND SPECIFICITY;
ANESTHETICS;
CHROMATOGRAPHY, LIQUID;
ETHERS;
LIMIT OF DETECTION;
MASS SPECTROMETRY;
PROPOFOL;
PYRIDINIUM COMPOUNDS;
REPRODUCIBILITY OF RESULTS;
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EID: 72049133186
PISSN: 15700232
EISSN: None
Source Type: Journal
DOI: 10.1016/j.jchromb.2009.10.010 Document Type: Article |
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Times cited : (34)
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References (26)
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