Synthesis and in vivo evaluation of 3,4-disubstituted gababutins

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 1, 2010, Pages 248-251

  Blakemore, David C ^a   Bryans, Justin S ^a   Carnell, Pauline ^a   Field, Mark J ^a   Kinsella, Natasha ^a   Kinsora, Jack K ^b   Meltzer, Leonard T ^b   Osborne, Simon A ^a   Thompson, Lisa R ^a   Williams, Sophie C ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b Groton Laboratories   (United States)

Author keywords

Anxiety; Gababutin; Gabapentin; Pain; Pregabalin

Indexed keywords

GABABUTIN DERIVATIVE; GABAPENTIN; PREGABALIN; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY DISORDER; ARTICLE; CONTROLLED STUDY; DRUG HALF LIFE; DRUG SYNTHESIS; IC 50; IN VIVO STUDY; NONHUMAN; PAIN; RAT; SUBSTITUTION REACTION;

AMINES; AMINO ACIDS; ANIMALS; ANTI-ANXIETY AGENTS; CYCLOHEXANECARBOXYLIC ACIDS; CYCLOPENTANES; DISEASE MODELS, ANIMAL; GAMMA-AMINOBUTYRIC ACID; HYPERALGESIA; RATS;

EID: 72049126069     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.10.121     Document Type: Article

References (19)

1. Bryans J.S., and Wustrow D.J. Med. Res. Rev. 19 (1999) 149
2. Pan H.L., Eisenach J.C., and Chen S.R.J. Pharmacol. Exp. Ther. 288 (1999) 1026
3. Hunter J.C., Gogas K.R., Hedley L.R., Jacobsen L.O., Kassotakis L., Thompson J., and Fontana D.J. Eur. J. Pharmacol. 324 (1997) 153
4. Singh L., Field M.J., Ferris P., Hunter J.C., Oles R.J., Williams R.G., and Woodruff G.N. Psychopharmacology 127 (1997) 1
5. de-Paris F., Busnello J.V., Vianna M.R.M., Salgueiro J.B., Quevedo J., Izquierdo I., and Kapczinski F. Behav. Pharmacol. 11 (2000) 169
6. Rice A.S.C., and Maton S. Pain 94 (2001) 215
7. Dworkin R.H., and Kirkpatrick P. Nat. Rev. Drug Disc. 4 (2005) 455
8. Zareba G. Drugs Today 41 (2005) 509
9. Guay D.R.P. Am. J. Geriatr. Pharmacother. 3 (2005) 274
10. Gee N.S., Brown J.P., Dissanayake V.U.K., Offord J., Thurlow R., and Woodruff G.N. J. Biol. Chem. 271 (1996) 5768
11. Stahl S.M. J. Clin. Psychiat. 65 (2004) 1033 and references cited therein
12. Blakemore D.C., Bryans J.S., Carnell P., Chessum N.E.A., Field M.J., Kinsella N., Kinsora J.K., Osborne S.A., and Williams S.C. Bioorg. Med. Chem. Lett. (2009) 10.1016/j.bmcl.2009.10.089
13. Furuta K., Iwanaga K., and Yamamoto H. Tetrahedron Lett. 27 (1996) 4507
14. Corey E.J., and Su W.-G. Tetrahedron Lett. 29 (1988) 3423
15. Solladie G., and Lohse O. J. Org. Chem. 58 (1993) 4555
16. Furuta K., Iwanaga K., and Yamamoto H. Tetrahedron Lett. 27 (1986) 4507
17. Deardorff D.R., and Myles D.C. Org. Synth. 67 (1989) 114
18. Deardorff D.R., Windham C.Q., and Craney C.L. Org. Synth. 73 (1995) 25
19. Johnson C.R., and Bis S.J. Tetrahedron Lett. 33 (1992) 7287