Direct determination of N-methyl-2-pyrrolidone metabolites in urine by HPLC-electrospray ionization-MS/MS using deuterium-labeled compounds as internal standard

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 29, 2009, Pages 3743-3747

  Suzuki, Yoshihiro ^a   Endo, Yoko ^a   Ogawa, Masanori ^a   Yamamoto, Shinobu ^b   Takeuchi, Akito ^b   Nakagawa, Tomoo ^c   Onda, Nobuhiko ^a  

^a TOKYO ROSAI HOSPITAL   (Japan)

^b JAPAN INDUSTRIAL SAFETY AND HEALTH ASSOCIATION   (Japan)

^c Yokohama City Institute of Health   (Japan)

Author keywords

2 Hydroxy N methylsuccinimide; 5 Hydoxy N methyl 2 pyrrolidone; Biological monitoring; Deuterium labeled compound; Electrospray ionization MS MS; N Methyl 2 pyrrolidone

Indexed keywords

ANALYTICAL METHOD; ATMOSPHERIC MONITORING; BASELINE SEPARATION; BIOLOGICAL EXPOSURE INDICES; BIOLOGICAL MONITORING; DIRECT DETERMINATION; ELECTROSPRAY IONIZATION MASS SPECTROMETRY; EXTERNAL QUALITY; INTERNAL STANDARDS; LIMITS OF DETECTION; LINEAR CALIBRATION; N-METHYL-2-PYRROLIDONE; OCCUPATIONAL HEALTH; SOLID-PHASE EXTRACTION; SUCCINIMIDE; URINE SAMPLE;

BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; COLUMN CHROMATOGRAPHY; DEUTERIUM; DEUTERIUM COMPOUNDS; ELECTROSPRAY IONIZATION; EXTRACTION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; INDUSTRIAL HYGIENE; IONIZATION; MASS SPECTROMETRY; METABOLISM; METABOLITES; PARTICLE DETECTORS;

IONIC LIQUIDS;

1 METHYL 2 PYRROLIDINONE; 2 HYDROXY N METHYLSUCCINIMIDE; 2 PYRROLIDONE DERIVATIVE; 5 HYDROXY N METHYL 2 PYRROLIDONE; DEUTERIUM; SUCCINIMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; BIOLOGICAL MONITORING; CALIBRATION; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTERMETHOD COMPARISON; ISOTOPE LABELING; METABOLITE; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HEALTH; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; STANDARD; URINALYSIS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEUTERIUM; HUMANS; PYRROLIDINONES; REFERENCE STANDARDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 72049120428     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.08.036     Document Type: Article

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