Ambient monitoring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility

International Archives of Occupational and Environmental Health

Volumn 79, Issue 5, 2006, Pages 357-364

  Bader, Michael ^a   Rosenberger, Wolfgang ^a   Rebe, Thomas ^a   Keener, Stephen A ^a   Brock, Thomas H ^b   Hemmerling, Hans Jürgen ^b   Wrbitzky, Renate ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b Institution for Statutory Accident Insurance and Prevention in Chemical Industry (BG Chemie)   (Germany)

Author keywords

Ambient monitoring; Biomonitoring; N methyl 2 pyrrolidone; Occupational exposure

Indexed keywords

1 METHYL 2 PYRROLIDINONE; 2 HYDROXY N METHYLSUCCINIMIDE; 2 PYRROLIDONE DERIVATIVE; 5 HYDROXY N METHYL 2 PYRROLIDONE; ACTIVATED CARBON; CREATININE; SUCCINIMIDE DERIVATIVE; UNCLASSIFIED DRUG;

AIR MONITORING; AMBIENT AIR; ARTICLE; BIOLOGICAL MONITORING; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENVIRONMENTAL MONITORING; EYE IRRITATION; GAS CHROMATOGRAPHY; HEADACHE; HUMAN; INDUSTRIAL WORKER; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HEALTH; PROTECTIVE CLOTHING; RESPIRATORY TRACT DISEASE; SHIFT WORKER; URINALYSIS; WORK ENVIRONMENT;

AIR POLLUTANTS, OCCUPATIONAL; ENVIRONMENTAL MONITORING; GERMANY; HUMANS; OCCUPATIONAL EXPOSURE; PYRROLIDINONES;

EID: 33645141303     PISSN: 03400131     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00420-005-0065-4     Document Type: Article

References (19)

1. Åkesson B (2001) N -Methyl-2-pyrrolidone. Concise international chemical assessment document 35, International Programme on Chemical Safety, World Health Organization, Geneva, http://www.inchem.org/documents/cicads/cicads/cicad35.htm
2. Åkesson B, Jönsson BAG (1997) Major metabolic pathway for N -methyl-2-pyrrolidone in humans. Drug Metab Dispos 25:267-269
3. Åkesson B, Jönsson BAG (2000) Biological monitoring of N -methyl-2-pyrrolidone using 5-hydroxy-N-methyl-2-pyrrolidone in plasma and urine as the biomarker. Scand J Work Environ Health 26:213-218
4. Åkesson B, Paulsson K (1997) Experimental exposure of male volunteers to N-methyl-2-pyrrolidone (NMP): Acute effects and pharmacokinetics of NMP in plasma and urine. Occup Environ Med 54:236-240
5. Anundi H, Lind ML, Friis L, Itkes N, Langworth S, Edling C (1993) High exposures to organic solvents among graffiti removers. Int Arch Occup Environ Health 65: 247-251
6. Anundi H, Langworth S, Johanson G, Lind ML, Åkesson B, Friis L, Itkes N, Söderman E, Jönsson BAG, Edling C (2000) Air and biological monitoring of solvent exposure during graffiti removal. Int Arch Occup Environ Health 73:561-569
7. Bader M, Keener SA, Wrbitzky R (2005) Dermal absorption and urinary elimination of N -methyl-2-pyrrolidone. Int Arch Occup Environ Health 8 (in press)
8. Bader M, Will W, Rossbacher R, Nasterlack M, Wrbitzky R (2002) N -Methyl-2-pyrrolidon-Arbeitsmedizinische Bedeutung und Toxikologie. Arbeitsmed, Sozialmed, Umweltmed 9:422-428
9. Beaulieu HJ, Schmerber KR (1991) M-Pyrol™ (NMP) use in the microelectronics industry. Appl Occup Environ Hyg 6:874-880
10. DIN EN 482 (2005) Workplace atmospheres-general requirements for the performance of procedures for the measurement of chemical agents. Beuth Verlag, Berlin, Wien, Zürich
11. Greim D, Lehnert G (eds) (1994) N -Methyl-2-pyrrolidon (Dampf). Maximale Arbeitsplatzkonzentrationen. Arbeitsmedizinisch-toxikologische Begründungen. Senatskommission zur Prüfung gesundheitsschǎdlicher Arbeitsstoffe. Deutsche Forschungsgemeinschaft. 20. Lieferung, Wiley-VCH, Weinheim
12. HSE (Health and Safety Executive): N -Methyl-2-pyrrolidone. Risk assessment document. EH72/10, ISBN 0717615286, HSE Books, Sudbury, UK, 1997
13. Jodie;nsson BAG, Åkesson B (1997) Determination of 5-hydroxy- N -methyl-2-pyrrolidone and 2-hydroxy- N -methylsuccinimide in human urine. J Chromatogr B 694:351-357
14. Jungbauer FHW, Coenraads PJ, Kardaun SH (2001) Toxic hygroscopic contact reaction to N -methyl-2-pyrrolidone. Contact Derm 45:303-304
15. Langworth S, Anundi H, Friis L, Johanson G, Lind ML, Söderman E, Åkesson B (2001) Acute health effects common during graffiti removal. Int Arch Occup Environ Health 74:213-218
16. Leira HL, Tiltnes A, Svendsen K, Vetlesen L (1992) Irritant cutaneous reactions to N -methyl-2-pyrrolidone (NMP). Contact Derm 27:148-150
17. Saillenfait AM, Gallissot F, Langonne I, Sabate JP (2002) Developmental toxicity of N -methyl-2-pyrrolidone administered orally to rats. Food Chem Toxicol 40:1705-1712
18. Saillenfait AM, Gallissot F, Morel G (2003) Developmental toxicity of N -methyl-2-pyrrolidone in rats following inhalation exposure. Food Chem Toxicol 41:583-588
19. Xiaofei E, Wada Y, Nozaki JI, Miyauchi H, Tanaka S, Seki Y, Koizumi A (2000) A linear pharmakokinetic model predicts usefulness of N -methyl-2-pyrrolidone (NMP) in plasma or urine as a biomarker for biological monitoring for NMP exposure. J Occup Health 42:321-327