2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 1, 2010, Pages 334-337

  Harris, Christopher M ^a   Ericsson, Anna M ^a   Argiriadi, Maria A ^a   Barberis, Claude ^a   Borhani, David W ^a   Burchat, Andrew ^a   Calderwood, David J ^a   Cunha, George A ^a   Dixon, Richard W ^a   Frank, Kristine E ^a   Johnson, Eric F ^a   Kamens, Joanne ^a   Kwak, Silvia ^a   Li, Biqin ^a   Mullen, Kelly D ^a   Perron, Denise C ^a   Wang, Lu ^a   Wishart, Neil ^a   Wu, Xiaoyun ^a   Zhang, Xiaolei ^a   Zmetra, Tami R ^a   Talanian, Robert V ^a   more..

^a ABBOTT LABORATORIES   (United States)

Author keywords

Diaminopyrimidine; MAPKAP K2; MK2; TNF

Indexed keywords

2,4 DIAMINOPYRIMIDINE DERIVATIVE; 2,4 DIAMINOPYRIMIDINE DERIVATIVE MK2 INHIBITOR; PROTEIN SERINE THREONINE KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MONOCYTE;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 72049120102     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.10.103     Document Type: Article

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