Bone marrow-derived progenitor cells in the early phase of ischemic stroke: Relation with stroke severity and discharge outcome

Journal of Cerebral Blood Flow and Metabolism

Volumn 29, Issue 12, 2009, Pages 1983-1990

  Cesari, Francesca ^a   Nencini, Patrizia ^b   Nesi, Mascia ^b   Caporale, Roberto ^b   Giusti, Betti ^a   Abbate, Rosanna ^a   Gori, Anna Maria ^a,c   Inzitari, Domenico ^b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b CAREGGI UNIVERSITY HOSPITAL   (Italy)

^c IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

Author keywords

Circulating progenitor cells; Ischemic stroke; Outcome

Indexed keywords

FIBRINOGEN;

ADULT; AGED; ARTICLE; BRAIN CIRCULATION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DISEASE SEVERITY; ENDOTHELIUM CELL; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; GROUPS BY AGE; HEMATOPOIETIC STEM CELL; HOSPITAL DISCHARGE; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REHABILITATION CARE;

ADULT; AGED; AGED, 80 AND OVER; BONE MARROW CELLS; CELL COUNT; ENDOTHELIAL CELLS; FEMALE; HUMANS; MALE; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); PATIENT DISCHARGE; SEVERITY OF ILLNESS INDEX; STEM CELLS; STROKE; YOUNG ADULT;

EID: 72049112307     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2009.178     Document Type: Article

References (28)

1. Brazelton TR, Rossi FM, Keshet GI, Blau HM (2000) From marrow to brain: expression of neuronal phenotypes in adult mice. Science 290:1775-1779
2. Cesari F, Caporale R, Marcucci R, Caciolli S, Stefano PL, Capalbo A, Macchi C, Vannucci M, Gensini GF, Abbate R, Gori AM (2008) NT-proBNP and the antiinflammatory cytokines are correlated with endothelial progenitor cells' response to cardiac surgery. Atherosclerosis 199:138-146
3. Cesari F, Sofi F, Caporale R, Capalbo A, Marcucci R, Macchi C, Molino Lova R, Cellai T, Vannucci M, Gensini GF, Abbate R, Gori AM (2009) Relationship between exercise capacity, endothelial progenitor cells and cytochemokines in patients undergoing cardiac rehabilitation. Thromb Haemost 101:521-526
4. Chu K, Jung KH, Lee ST, Park HK, Sinn DI, Kim JM, Kim DH, Kim JH, Kim SJ, Song EC, Kim M, Lee SK, Roh JK (2008) Circulating endothelial progenitor cells as a new marker of endothelial dysfunction or repair in acute stroke. Stroke 39:1441-1447
5. Cifkova R, Erdine S, Fagard R, Farsang C, Heagerty AM, Kiowski W, Kjeldsen S, Lüscher T, Mallion JM, Mancia G, Poulter N, Rahn KH, Rodicio JL, Ruilope LM, van Zwieten P, Waeber B, Williams B, Zanchetti A (2003) Practice guidelines for primary care physicians: 2003 ESH/ESC Hypertension guidelines. ESH/ESC hypertension guidelines committee. Hypertension 21:1779-1786
6. Eglitis MA, Mezey E (1997) Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice. Proc Natl Acad Sci USA 94:4080-4085
7. Ghani U, Shuaib A, Salam A, Nasir A, Shuaib U, Jeerakathil T, Sher F, O'Rourke F, Nasser A, Schwindt B, Todd K (2005) Endothelial progenitor cells during cerebrovascular disease. Stroke 36:151-153
8. Heeschen C, Aicher A, Lehmann R, Fichtlschererer S, Vasa M, Urbich C, Mildner-Rihm C, Martin H, Zeiher AM, Dimmeler S (2003) Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization. Blood 102:1340-1346
9. Hess DC, Hill WD, Martin-Studdard A, Carroll J, Brailer J, Carothers J (2002) Bone marrow as a source of endothelial cells and NeuN-expressing cells after stroke. Stroke 33:1362-1368
10. Ikenaga S, Hamano K, Nishida M, Kobayashi T, Li TS, Kobayashi S, Matsuzaki M, Zempo N, Esato K (2001) Autologus bone marrow implantation induced angiogenesis and improved deteriorated exercise capacity in a rat ischemic hindlimb model. J Surg Res 96:277-283
11. Kalka C, Masuda H, Takahashi T, Kalka-Moll WM, Silver M, Kearney M, Li T, Isner JM, Asahara T (2000) Transplantation of ex-vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc Natl Acad Sci USA 97:3422-3427
12. Laufs U, Werner N, Link A, Endres M, Wassmann S, Jürgens K, Miche E, Böhm M, Nickenig G (2004) Physical training increases endothelial progenitor cells, inhibits neointima formation and enhances angiogenesis. Circulation 109:220-226
13. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, Pickel J, McKay R, Nadal-Ginard B, Bodine DM, Leri A, Anversa P (2001) Bone marrow cells regenerate infarcted myocardium. Nature 410:701-705
14. Pistrosch F, Herbrig K, Oelschlaegel U, Richter S, Passauer J, Fischer S, Gross P (2005) PPARg-agonist rosiglitazone increases number and migratory activity of cultured endothelial progenitor cells. Atherosclerosis 185:163-167
15. Priller J, Flugel A, Wehner T, Boentert M, Haas CA, Prinz M, Fernandez-Klett F, Prass K, Bechmann I, de Boer BA, Frotscher M, Kreutberg GW, Persons DA, Dirnagl U (2001) Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment. Nat Med 7:1356-1361
16. Rafii S, Meeus S, Dias S, Hattori K, Heissig B, Shmelkov S, Rafii D, Lyden D (2002) Contribution of marrow-derived progenitors to vascular and cardiac regeneration. Semin Cell Dev Biol 13:61-67
17. Expert Committee on the diagnosis and classification of diabetes mellitus (2003) Report of the expert committee on the diagnosis and classification of diabetes mellitus . Diabetes Care 26:5-20
18. Sobrino T, Hurtado O, Moro MA, Rodriguez-Yanez M, Castellanos M, Brea D, Moldes O, Blanco M, Arenillas J, Leira R, Davalos A, Lizasoian I, Castillo J (2007) The increase of circulating endothelial progenitor cells after acute ischemic stroke is associated with good outcome. Stroke 38:2759-2764
19. Sutherland DR, Anderson L, Keeney M, Nayar R, Chin-Yee I (1996) The ISHAGE guidelines for CD34+ cell determination by flow cytometry. International Society of Hematotherapy and Graft Engineering. J Hematother 5:213-226
20. Taguchi A, Soma T, Tanaka H, Kanda T, Nishimura H, Yoshikawa H, Tsukamoto Y, Iso H, Fujimori Y, Stern D, Naritomi H, Matsuyama T (2004a) Administration of CD34+ cells after stroke enhances neurogenesis via angiogenegis in a mouse model. J Clin Invest 114:330-338
21. Taguchi A, Matsuyama T, Moriwaki H, Hayashi T, Hayashida K, Nagatsuka K, Todo K, Mori K, Stern D, Soma T, Naritomi H (2004b) Circulating CD34-positive cells provide an index of cerebrovascular function. Circulation 109:2972-2975
22. Taguchi A, Matsuyama T, Nakagomi T, Shimizu Y, Fukunaga R, Tatsuni Y, Yoshikawa H, Kikuchi-Taura A, Soma T, Moriwaki H, Nagatsuka K, Stern D, Naritomi H (2008) Circulating CD34-positive cells provide a marker of vascular risk associated with cognitive impairment. J Cereb Blood Flow Metab 28:445-449
23. Taguchi A, Nakagomi N, Matsuyama T, Kikuchi-Taura A, Yoshikawa H, Kasahara Y, Hirose H, Moriwaki H, Nakagomi T, Soma T, Stern D, Naritomi H (2009) Circulating CD34-positive cells have prognostic value for neurologic function in patients with past cerebral infarction. J Cereb Blood Flow Metab 29:34-38
24. Third report of the National Cholesterol Education Program (NCEP) (2002) Expert panel on detection, evaluation, and treatment of high blood cholesterol in adult (Adult Treatment Panel III) final report. Circulation 106:3143-3421
25. Vasa M, Fichtlschererer S, Adler K, Aicher A, Martin H, Zeiher AM, Dimmeler S (2001) Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease. Circulation 103:2885-2890
26. Yip HK, Chang L-T, Chang W-N, Lu C-H, Liou C-W, Lan MY, Liu J, Youssef A, Chang H-W (2008) Level and value of circulating endothelial progenitor cells in patients after acute ischemic stroke. Stroke 39:69-74
27. Zhang ZG, Zhang L, Jiang Q, Chopp M (2002) Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse. Circ Res 90:284-288
28. Zhao LR, Duan WM, Reyes M, Keene CD, Verfaillie CM, Low WC (2002) Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats. Exp Neurol 174:11-20