A model to identify novel targets involved in oxidative stress-induced apoptosis in human lung epithelial cells by RNA interference

Toxicology in Vitro

Volumn 24, Issue 1, 2010, Pages 310-318

  Wixted, William E ^a   Kitson, Chris ^b   Colebrook, Jayne C ^b   Roberts, Emma J ^b   Fox, Steven M ^b   Kou, Jen P ^a   Li, Jun U ^a   López Boado, Yolanda S ^a  

^a GLAXOSMITHKLINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Alveolar destruction; Apoptosis; Chronic lung disease; Gene expression knockdown; Human druggable genome; Oxidative stress

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; HIGH MOBILITY GROUP B2 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; PROTEASOME; RIBOSOME PROTEIN; RIBOSOME PROTEIN 27; RIBOSOME PROTEIN 7A; RIBOSOME PROTEIN A; RIBOSOME PROTEIN L35; RIBOSOME PROTEIN S27A; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL ASSAY; CONTROLLED STUDY; GENE LIBRARY; GENE TARGETING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; OXIDATIVE STRESS; PROTEIN ANALYSIS; REGULATORY MECHANISM; RNA INTERFERENCE;

ANTIOXIDANTS; APOPTOSIS; CASPASES; CELL LINE; CYTOKINES; DRUG EVALUATION, PRECLINICAL; EPITHELIAL CELLS; FLOW CYTOMETRY; GENE LIBRARY; HUMANS; HYDROGEN PEROXIDE; LUNG; OXIDANTS; OXIDATIVE STRESS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 72049112306     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.08.008     Document Type: Article

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