Liquid chromatography/positive ion electrospray tandem mass spectrometry method for the quantification of hydrochloride meptazinol in human plasma: Application to a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 30, 2009, Pages 3787-3791

  Qiao, Jian ^a   Tan, Zhirong ^b   Li, Weiyong ^a   Huang, Lu ^a   Ge, Miaomiao ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Hydrochloride meptazinol; LC MS MS; Pharmacokinetic

Indexed keywords

AMMONIUM FORMATE; CALIBRATION CURVES; CYANO COLUMNS; HPLC SEPARATION; HUMAN PLASMAS; HYDROCHLORIDE MEPTAZINOL; ION ELECTROSPRAY; LC-MS/MS; LIMIT OF QUANTIFICATIONS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID-LIQUID EXTRACTION; MOBILE PHASE; MULTIPLE-REACTION MONITORING MODES; PHARMACOKINETIC STUDIES; POSITIVE ELECTROSPRAY IONIZATION;

ACETONITRILE; AMMONIUM COMPOUNDS; CHROMATOGRAPHIC ANALYSIS; ELECTROSPRAY IONIZATION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMA (HUMAN);

SOLVENT EXTRACTION;

ACETONITRILE; AMMONIUM FORMATE; MEPTAZINOL; PARACETAMOL;

ACCURACY; ADULT; AREA UNDER THE CURVE; ARTICLE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; FEMALE; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MASS SPECTROMETER; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; POSITIVE ION ELECTROSPRAY; PRIORITY JOURNAL; QUANTITATIVE ASSAY; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANALGESICS, OPIOID; CHROMATOGRAPHY, LIQUID; FEMALE; HUMANS; MALE; MEPTAZINOL; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 72049111545     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.08.051     Document Type: Article

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