메뉴 건너뛰기




Volumn 18, Issue SUPPL.3, 2009, Pages

Issues regarding improving the impact of antiangiogenic drugs for the treatment of breast cancer

Author keywords

Bevacizumab; Drug resistance; Endothelial progenitor cells; Metronomic chemotherapy; VEGF

Indexed keywords

ANGIOGENESIS INHIBITOR; BEVACIZUMAB; CAPECITABINE; CYCLOPHOSPHAMIDE; FUMAGILLOL CHLOROACETYLCARBAMATE; GEMCITABINE; GRANULOCYTE COLONY STIMULATING FACTOR; METHOTREXATE; MONOCLONAL ANTIBODY DC101; PACLITAXEL; SORAFENIB; SUNITINIB; TRASTUZUMAB; UFT; VASCULOTROPIN;

EID: 72049110823     PISSN: 09609776     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9776(09)70271-1     Document Type: Article
Times cited : (33)

References (70)
  • 1
    • 43249095919 scopus 로고    scopus 로고
    • Tumor Angiogenesis
    • Kerbel R.S. Tumor Angiogenesis. N Engl J Med 358 (2008) 2039-2049
    • (2008) N Engl J Med , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 3
    • 33744466541 scopus 로고    scopus 로고
    • Antiangiogenic therapy: a universal chemosensitization strategy for cancer?
    • Kerbel R.S. Antiangiogenic therapy: a universal chemosensitization strategy for cancer?. Science 312 (2006) 1171-1175
    • (2006) Science , vol.312 , pp. 1171-1175
    • Kerbel, R.S.1
  • 4
    • 60549112008 scopus 로고    scopus 로고
    • Antiangiogenic therapy for metastatic breast cancer: current status and future directions
    • Chan A. Antiangiogenic therapy for metastatic breast cancer: current status and future directions. Drugs 69 (2009) 167-181
    • (2009) Drugs , vol.69 , pp. 167-181
    • Chan, A.1
  • 5
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K., Wang M., Gralow J., Dickler M., Cobleigh M., Perez E.A., et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 357 (2007) 2666-2676
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3    Dickler, M.4    Cobleigh, M.5    Perez, E.A.6
  • 6
    • 54249120945 scopus 로고    scopus 로고
    • Randomized, double-blind placebo-controlled, phase III study of bevacizumab (BV) with docetaxel (D) or D with placebo (PL) as 1st-line therapy for patients with locally recurrent or metastatic breast cancer (mBC): AVADO
    • Miles D., Chan A., Romieu G., et al. Randomized, double-blind placebo-controlled, phase III study of bevacizumab (BV) with docetaxel (D) or D with placebo (PL) as 1st-line therapy for patients with locally recurrent or metastatic breast cancer (mBC): AVADO. Proc Am Soc Clin Oncol 26 (2008) LBA1011
    • (2008) Proc Am Soc Clin Oncol , vol.26
    • Miles, D.1    Chan, A.2    Romieu, G.3
  • 7
    • 20044364346 scopus 로고    scopus 로고
    • Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer
    • Miller K.D., Chap L.I., Holmes F.A., Cobleigh M.A., Marcom P.K., Fehrenbacher L., et al. Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J Clin Oncol 23 (2005) 792-799
    • (2005) J Clin Oncol , vol.23 , pp. 792-799
    • Miller, K.D.1    Chap, L.I.2    Holmes, F.A.3    Cobleigh, M.A.4    Marcom, P.K.5    Fehrenbacher, L.6
  • 8
    • 32944478346 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer
    • Kindler H.L., Friberg G., Singh D.A., Locker G., Nattam S., Kozloff M., et al. Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer. J Clin Oncol 23 (2005) 8033-8040
    • (2005) J Clin Oncol , vol.23 , pp. 8033-8040
    • Kindler, H.L.1    Friberg, G.2    Singh, D.A.3    Locker, G.4    Nattam, S.5    Kozloff, M.6
  • 9
    • 60549098640 scopus 로고    scopus 로고
    • Sorafenib: a review of its use in advanced hepatocellular carcinoma
    • Keating G.M., and Santoro A. Sorafenib: a review of its use in advanced hepatocellular carcinoma. Drugs 69 (2009) 223-240
    • (2009) Drugs , vol.69 , pp. 223-240
    • Keating, G.M.1    Santoro, A.2
  • 11
    • 58149335533 scopus 로고    scopus 로고
    • Phase II trial of sorafenib in patients with metastatic breast cancer previously exposed to anthracyclines or taxanes: North Central Cancer Treatment Group and Mayo Clinic Trial N0336
    • Moreno-Aspitia A., Morton R.F., Hillman D.W., Lingle W.L., Rowland Jr. K.M., Wiesenfeld M., et al. Phase II trial of sorafenib in patients with metastatic breast cancer previously exposed to anthracyclines or taxanes: North Central Cancer Treatment Group and Mayo Clinic Trial N0336. J Clin Oncol 27 (2009) 11-15
    • (2009) J Clin Oncol , vol.27 , pp. 11-15
    • Moreno-Aspitia, A.1    Morton, R.F.2    Hillman, D.W.3    Lingle, W.L.4    Rowland Jr., K.M.5    Wiesenfeld, M.6
  • 12
    • 50849089255 scopus 로고    scopus 로고
    • Reversible tumor growth acceleration following bevacizumab interruption in metastatic colorectal cancer patients scheduled for surgery
    • Cacheux W., Boisserie T., Staudacher L., Vignaux O., Dousset B., Soubrane O., et al. Reversible tumor growth acceleration following bevacizumab interruption in metastatic colorectal cancer patients scheduled for surgery. Ann Oncol 19 (2008) 1659-1661
    • (2008) Ann Oncol , vol.19 , pp. 1659-1661
    • Cacheux, W.1    Boisserie, T.2    Staudacher, L.3    Vignaux, O.4    Dousset, B.5    Soubrane, O.6
  • 13
    • 42949148257 scopus 로고    scopus 로고
    • Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
    • Burstein H.J., Elias A.D., Rugo H.S., Cobleigh M.A., Wolff A.C., Eisenberg P.D., et al. Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J Clin Oncol 26 (2008) 1810-1816
    • (2008) J Clin Oncol , vol.26 , pp. 1810-1816
    • Burstein, H.J.1    Elias, A.D.2    Rugo, H.S.3    Cobleigh, M.A.4    Wolff, A.C.5    Eisenberg, P.D.6
  • 14
    • 60649106195 scopus 로고    scopus 로고
    • Anti-angiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • in press
    • Paez-Ribes M, Allen E, Hudock J, Takeda T, Okuyama H, Vinals F, et al. Anti-angiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009; in press.
    • (2009) Cancer Cell
    • Paez-Ribes, M.1    Allen, E.2    Hudock, J.3    Takeda, T.4    Okuyama, H.5    Vinals, F.6
  • 15
    • 0033822622 scopus 로고    scopus 로고
    • Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption
    • Rubenstein J.L., Kim J., Ozawa T., Zhang M., Westphal M., Deen D.F., et al. Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia 2 (2000) 306-314
    • (2000) Neoplasia , vol.2 , pp. 306-314
    • Rubenstein, J.L.1    Kim, J.2    Ozawa, T.3    Zhang, M.4    Westphal, M.5    Deen, D.F.6
  • 16
    • 39849102836 scopus 로고    scopus 로고
    • HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    • Du R., Lu K.V., Petritsch C., Liu P., Ganss R., Passegue E., et al. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 13 (2008) 206-220
    • (2008) Cancer Cell , vol.13 , pp. 206-220
    • Du, R.1    Lu, K.V.2    Petritsch, C.3    Liu, P.4    Ganss, R.5    Passegue, E.6
  • 17
    • 41649112610 scopus 로고    scopus 로고
    • Bevacizumab for recurrent malignant gliomas: efficacy, toxicity, and patterns of recurrence
    • Norden A.D., Young G.S., Setayesh K., Muzikansky A., Klufas R., Ross G.L., et al. Bevacizumab for recurrent malignant gliomas: efficacy, toxicity, and patterns of recurrence. Neurology 70 (2008) 779-787
    • (2008) Neurology , vol.70 , pp. 779-787
    • Norden, A.D.1    Young, G.S.2    Setayesh, K.3    Muzikansky, A.4    Klufas, R.5    Ross, G.L.6
  • 18
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G., and Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8 (2008) 592-603
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 19
    • 30944446883 scopus 로고    scopus 로고
    • Lessons from phase III clinical trials on anti-VEGF therapy for cancer
    • Jain R.K., Duda D.G., Clark J.W., and Loeffler J.S. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol 3 (2006) 24-40
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 24-40
    • Jain, R.K.1    Duda, D.G.2    Clark, J.W.3    Loeffler, J.S.4
  • 20
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • Jain R.K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307 (2005) 58-62
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 21
    • 34547617338 scopus 로고    scopus 로고
    • Antiangiogenic strategies on defense: blocking rebound by the tumor vasculature after chemotherapy
    • Shaked Y., and Kerbel R.S. Antiangiogenic strategies on defense: blocking rebound by the tumor vasculature after chemotherapy. Cancer Res 67 (2007) 7055-7058
    • (2007) Cancer Res , vol.67 , pp. 7055-7058
    • Shaked, Y.1    Kerbel, R.S.2
  • 22
    • 33749005405 scopus 로고    scopus 로고
    • Therapyinduced acute recruitment of circulating endothelial progenitor cells to tumors
    • Shaked Y., Ciarrocchi A., Franco M., Lee C.R., Man S., Cheung A.M., et al. Therapyinduced acute recruitment of circulating endothelial progenitor cells to tumors. Science 313 (2006) 1785-1787
    • (2006) Science , vol.313 , pp. 1785-1787
    • Shaked, Y.1    Ciarrocchi, A.2    Franco, M.3    Lee, C.R.4    Man, S.5    Cheung, A.M.6
  • 23
    • 50349097617 scopus 로고    scopus 로고
    • Rapid chemotherapy-induced surge in endothelial progenitor cells: implications for antiangiogenic drugs as chemosensitizing agents
    • Shaked Y., Henke E., Roodhart J., Mancuso P., Langenberg M., Colleoni M., et al. Rapid chemotherapy-induced surge in endothelial progenitor cells: implications for antiangiogenic drugs as chemosensitizing agents. Cancer Cell 14 (2008) 263-273
    • (2008) Cancer Cell , vol.14 , pp. 263-273
    • Shaked, Y.1    Henke, E.2    Roodhart, J.3    Mancuso, P.4    Langenberg, M.5    Colleoni, M.6
  • 24
    • 0025717523 scopus 로고
    • Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents
    • Kerbel R.S. Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents. BioEssays 13 (1991) 31-36
    • (1991) BioEssays , vol.13 , pp. 31-36
    • Kerbel, R.S.1
  • 25
    • 0035865363 scopus 로고    scopus 로고
    • Redefining the target: chemotherapeutics as antiangiogenics
    • Miller K.D., Sweeney C.J., and Sledge Jr. G.W. Redefining the target: chemotherapeutics as antiangiogenics. J Clin Oncol 19 (2001) 1195-1206
    • (2001) J Clin Oncol , vol.19 , pp. 1195-1206
    • Miller, K.D.1    Sweeney, C.J.2    Sledge Jr., G.W.3
  • 26
    • 0035870297 scopus 로고    scopus 로고
    • The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors
    • Sweeney C.J., Miller K.D., Sissons S.E., Nozaki S., Heilman D.K., Shen J., et al. The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors. Cancer Res 61 (2001) 3369-3372
    • (2001) Cancer Res , vol.61 , pp. 3369-3372
    • Sweeney, C.J.1    Miller, K.D.2    Sissons, S.E.3    Nozaki, S.4    Heilman, D.K.5    Shen, J.6
  • 27
    • 0034087691 scopus 로고    scopus 로고
    • Continuous lowdose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
    • Klement G., Baruchel S., Rak J., Man S., Clark K., Hicklin D., et al. Continuous lowdose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J Clin Invest 105 (2000) R15-R24
    • (2000) J Clin Invest , vol.105
    • Klement, G.1    Baruchel, S.2    Rak, J.3    Man, S.4    Clark, K.5    Hicklin, D.6
  • 28
    • 0034032882 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
    • Browder T., Butterfield C.E., Kraling B.M., Marshall B., O'Reilly M.S., and Folkman J. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res 60 (2000) 1878-1886
    • (2000) Cancer Res , vol.60 , pp. 1878-1886
    • Browder, T.1    Butterfield, C.E.2    Kraling, B.M.3    Marshall, B.4    O'Reilly, M.S.5    Folkman, J.6
  • 29
    • 0031469819 scopus 로고    scopus 로고
    • Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
    • Boehm T., Folkman J., Browder T., and O'Reilly M.S. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature 390 (1997) 404-407
    • (1997) Nature , vol.390 , pp. 404-407
    • Boehm, T.1    Folkman, J.2    Browder, T.3    O'Reilly, M.S.4
  • 30
    • 0031038068 scopus 로고    scopus 로고
    • Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis
    • Relf M., LeJeune S., Scott P.A., Fox S., Smith K., Leek R., et al. Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res 57 (1997) 963-969
    • (1997) Cancer Res , vol.57 , pp. 963-969
    • Relf, M.1    LeJeune, S.2    Scott, P.A.3    Fox, S.4    Smith, K.5    Leek, R.6
  • 31
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late stage pancreatic islet tumors
    • Casanovas O., Hicklin D., Bergers G., and Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late stage pancreatic islet tumors. Cancer Cell 8 (2005) 299-309
    • (2005) Cancer Cell , vol.8 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.2    Bergers, G.3    Hanahan, D.4
  • 32
    • 7944229106 scopus 로고    scopus 로고
    • Vascular remodeling and clinical resistance to antiangiogenic cancer therapy
    • Glade Bender J., Cooney E.M., Kandel J.J., and Yamashiro D.J. Vascular remodeling and clinical resistance to antiangiogenic cancer therapy. Drug Resist Updat 7 (2004) 289-300
    • (2004) Drug Resist Updat , vol.7 , pp. 289-300
    • Glade Bender, J.1    Cooney, E.M.2    Kandel, J.J.3    Yamashiro, D.J.4
  • 33
    • 0037154738 scopus 로고    scopus 로고
    • Effect of p53 status on tumor response to antiangiogenic therapy
    • Yu J.L., Rak J.W., Coomber B.L., Hicklin D.J., and Kerbel R.S. Effect of p53 status on tumor response to antiangiogenic therapy. Science 295 (2002) 1526-1528
    • (2002) Science , vol.295 , pp. 1526-1528
    • Yu, J.L.1    Rak, J.W.2    Coomber, B.L.3    Hicklin, D.J.4    Kerbel, R.S.5
  • 34
    • 0037703383 scopus 로고    scopus 로고
    • Angiogenesis inhibitors: motivators of metastasis?
    • Steeg P.S. Angiogenesis inhibitors: motivators of metastasis?. Nat Med 9 (2003) 822-823
    • (2003) Nat Med , vol.9 , pp. 822-823
    • Steeg, P.S.1
  • 35
    • 0038172576 scopus 로고    scopus 로고
    • Cancer: Out of air is not out of action
    • Bottaro D.P., and Liotta L.A. Cancer: Out of air is not out of action. Nature 423 (2003) 593-595
    • (2003) Nature , vol.423 , pp. 593-595
    • Bottaro, D.P.1    Liotta, L.A.2
  • 36
    • 40249103199 scopus 로고    scopus 로고
    • A hypoxic twist in metastasis
    • Peinado H., and Cano A. A hypoxic twist in metastasis. Nat Cell Biol 10 (2008) 253-254
    • (2008) Nat Cell Biol , vol.10 , pp. 253-254
    • Peinado, H.1    Cano, A.2
  • 38
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • Dean M., Fojo T., and Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer 5 (2005) 275-284
    • (2005) Nat Rev Cancer , vol.5 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 39
    • 56749169353 scopus 로고    scopus 로고
    • Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE)
    • Grothey A., Sugrue M.M., Purdie D.M., Dong W., Sargent D., Hedrick E., et al. Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE). J Clin Oncol 26 (2008) 5326-5334
    • (2008) J Clin Oncol , vol.26 , pp. 5326-5334
    • Grothey, A.1    Sugrue, M.M.2    Purdie, D.M.3    Dong, W.4    Sargent, D.5    Hedrick, E.6
  • 40
    • 56749182275 scopus 로고    scopus 로고
    • Bevacizumab beyond progression: does this make sense?
    • Ellis L.M., and Haller D.G. Bevacizumab beyond progression: does this make sense?. J Clin Oncol 26 (2008) 5313-5315
    • (2008) J Clin Oncol , vol.26 , pp. 5313-5315
    • Ellis, L.M.1    Haller, D.G.2
  • 41
    • 33644833910 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
    • Motzer R.J., Michaelson M.D., Redman B.G., Hudes G.R., Wilding G., Figlin R.A., et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 24 (2006) 16-24
    • (2006) J Clin Oncol , vol.24 , pp. 16-24
    • Motzer, R.J.1    Michaelson, M.D.2    Redman, B.G.3    Hudes, G.R.4    Wilding, G.5    Figlin, R.A.6
  • 42
    • 34249073831 scopus 로고    scopus 로고
    • Bloodbased biomarkers of SU11248 activity and clinical outcome in patients with metastatic imatinib-resistant gastrointestinal stromal tumor
    • Norden-Zfoni A., Desai J., Manola J., Beaudry P., Force J., Maki R., et al. Bloodbased biomarkers of SU11248 activity and clinical outcome in patients with metastatic imatinib-resistant gastrointestinal stromal tumor. Clin Cancer Res 13 (2007) 2643-2650
    • (2007) Clin Cancer Res , vol.13 , pp. 2643-2650
    • Norden-Zfoni, A.1    Desai, J.2    Manola, J.3    Beaudry, P.4    Force, J.5    Maki, R.6
  • 43
    • 36749052895 scopus 로고    scopus 로고
    • Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with anti-tumor efficacy
    • Ebos J.M.L., Lee C.R., Christensen J.G., Mutsaers A.J., and Kerbel R.S. Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with anti-tumor efficacy. Proc Natl Acad Sci USA 104 (2007) 17069-17074
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 17069-17074
    • Ebos, J.M.L.1    Lee, C.R.2    Christensen, J.G.3    Mutsaers, A.J.4    Kerbel, R.S.5
  • 44
    • 34548361610 scopus 로고    scopus 로고
    • Osteopontin gene expression determines spontaneous metastatic performance of orthotopic human breast cancer xenografts
    • Suzuki M., Mose E., Galloy C., and Tarin D. Osteopontin gene expression determines spontaneous metastatic performance of orthotopic human breast cancer xenografts. Am J Pathol 171 (2007) 682-692
    • (2007) Am J Pathol , vol.171 , pp. 682-692
    • Suzuki, M.1    Mose, E.2    Galloy, C.3    Tarin, D.4
  • 45
    • 2942615257 scopus 로고    scopus 로고
    • Antiangiogenic basis of low-dose metronomic chemotherapy
    • Kerbel R.S., and Kamen B.A. Antiangiogenic basis of low-dose metronomic chemotherapy. Nat Rev Cancer 4 (2004) 423-436
    • (2004) Nat Rev Cancer , vol.4 , pp. 423-436
    • Kerbel, R.S.1    Kamen, B.A.2
  • 46
    • 33645744835 scopus 로고    scopus 로고
    • Highly efficacious nontoxic treatment for advanced metastatic breast cancer using combination UFT- cyclophosphamide metronomic chemotherapy
    • Munoz R., Man S., Shaked Y., Lee C., Wong J., Francia G., et al. Highly efficacious nontoxic treatment for advanced metastatic breast cancer using combination UFT- cyclophosphamide metronomic chemotherapy. Cancer Res 66 (2006) 3386-3391
    • (2006) Cancer Res , vol.66 , pp. 3386-3391
    • Munoz, R.1    Man, S.2    Shaked, Y.3    Lee, C.4    Wong, J.5    Francia, G.6
  • 47
    • 32944458087 scopus 로고    scopus 로고
    • Strategies for delaying or treating in vivo acquired resistance to trastuzumab (Herceptin®) in human breast cancer xenografts
    • du Manoir J.M., Francia G., Man S., Mossoba M., Medin J.A., Viloria-Petit A., et al. Strategies for delaying or treating in vivo acquired resistance to trastuzumab (Herceptin®) in human breast cancer xenografts. Clin Cancer Res 12 (2006) 904-916
    • (2006) Clin Cancer Res , vol.12 , pp. 904-916
    • du Manoir, J.M.1    Francia, G.2    Man, S.3    Mossoba, M.4    Medin, J.A.5    Viloria-Petit, A.6
  • 48
    • 55749115253 scopus 로고    scopus 로고
    • Long term progression and therapeutic response of visceral metastatic disease non-invasively monitored in mouse urine using beta-hCG choriogonadotropin secreting tumor cell lines
    • Francia G., Emmenegger U., Lee C.R., Shaked Y., Folkins C., Mossoba M., et al. Long term progression and therapeutic response of visceral metastatic disease non-invasively monitored in mouse urine using beta-hCG choriogonadotropin secreting tumor cell lines. Mol Cancer Ther 7 (2008) 3452-3459
    • (2008) Mol Cancer Ther , vol.7 , pp. 3452-3459
    • Francia, G.1    Emmenegger, U.2    Lee, C.R.3    Shaked, Y.4    Folkins, C.5    Mossoba, M.6
  • 49
    • 0034048358 scopus 로고    scopus 로고
    • Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice
    • Hanahan D., Bergers G., and Bergsland E. Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice. J Clin Invest 105 (2000) 1045-1047
    • (2000) J Clin Invest , vol.105 , pp. 1045-1047
    • Hanahan, D.1    Bergers, G.2    Bergsland, E.3
  • 50
    • 0041589524 scopus 로고    scopus 로고
    • Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells
    • Bertolini F., Paul S., Mancuso P., Monestiroli S., Gobbi A., Shaked Y., et al. Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells. Cancer Res 63 (2003) 4342-4346
    • (2003) Cancer Res , vol.63 , pp. 4342-4346
    • Bertolini, F.1    Paul, S.2    Mancuso, P.3    Monestiroli, S.4    Gobbi, A.5    Shaked, Y.6
  • 51
    • 33344459620 scopus 로고    scopus 로고
    • Circulating endothelial cells and angiogenic serum factors during neoadjuvant chemotherapy or primary breast cancer
    • F ̈ urstenberger G., von Moos R., Lucas R., Thürlimann B., Senn H.-J., Hamacher J., et al. Circulating endothelial cells and angiogenic serum factors during neoadjuvant chemotherapy or primary breast cancer. Br J Cancer 94 (2006) 524-531
    • (2006) Br J Cancer , vol.94 , pp. 524-531
    • F ̈ urstenberger, G.1    von Moos, R.2    Lucas, R.3    Thürlimann, B.4    Senn, H.-J.5    Hamacher, J.6
  • 52
    • 19944432454 scopus 로고    scopus 로고
    • Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis: implications for cellular surrogate marker analysis of antiangiogenesis
    • Shaked Y., Bertolini F., Man S., Rogers M.S., Cervi D., Foutz T., et al. Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis: implications for cellular surrogate marker analysis of antiangiogenesis. Cancer Cell 7 (2005) 101-111
    • (2005) Cancer Cell , vol.7 , pp. 101-111
    • Shaked, Y.1    Bertolini, F.2    Man, S.3    Rogers, M.S.4    Cervi, D.5    Foutz, T.6
  • 53
    • 27644436870 scopus 로고    scopus 로고
    • The optimal biological dose of metronomic chemotherapy regimens is associated with maximum antiangiogenic activity
    • Shaked Y., Emmengger U., Man S., Cervi D., Bertolini F., Ben-David Y., et al. The optimal biological dose of metronomic chemotherapy regimens is associated with maximum antiangiogenic activity. Blood 106 (2005) 3058-3061
    • (2005) Blood , vol.106 , pp. 3058-3061
    • Shaked, Y.1    Emmengger, U.2    Man, S.3    Cervi, D.4    Bertolini, F.5    Ben-David, Y.6
  • 54
    • 14644446018 scopus 로고    scopus 로고
    • A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
    • Pietras K., and Hanahan D. A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J Clin Oncol 23 (2005) 939-952
    • (2005) J Clin Oncol , vol.23 , pp. 939-952
    • Pietras, K.1    Hanahan, D.2
  • 55
    • 37849035249 scopus 로고    scopus 로고
    • Phase II clinical trial of bevacizumab and low dose metronomic oral cyclophosphamide in recurrent ovarian cancer. A trial of the California, Chicago and Princess Margaret Hospital Phase II Consortia
    • Garcia A.A., Hirte H., Fleming G., Yang D., Tsao-Wei D.D., Roman L., et al. Phase II clinical trial of bevacizumab and low dose metronomic oral cyclophosphamide in recurrent ovarian cancer. A trial of the California, Chicago and Princess Margaret Hospital Phase II Consortia. J Clin Oncol 26 (2007) 76-82
    • (2007) J Clin Oncol , vol.26 , pp. 76-82
    • Garcia, A.A.1    Hirte, H.2    Fleming, G.3    Yang, D.4    Tsao-Wei, D.D.5    Roman, L.6
  • 56
    • 54449099774 scopus 로고    scopus 로고
    • Metronomic cyclophosphamide and capecitabine combined with bevacizumab in advanced breast cancer: clinical and biological activity
    • Dellapasqua S., Bertolini F., Bagnardi V., Campagnoli E., Scarano E., Torrisi R., et al. Metronomic cyclophosphamide and capecitabine combined with bevacizumab in advanced breast cancer: clinical and biological activity. J Clin Oncol 26 (2008) 4899-4905
    • (2008) J Clin Oncol , vol.26 , pp. 4899-4905
    • Dellapasqua, S.1    Bertolini, F.2    Bagnardi, V.3    Campagnoli, E.4    Scarano, E.5    Torrisi, R.6
  • 57
    • 16544369867 scopus 로고    scopus 로고
    • A randomized trial of adjuvant chemotherapy with uracil-tegafur for adenocarcinoma of the lung
    • Kato H., Ichinose Y., Ohta M., Hata E., Tsubota N., Tada H., et al. A randomized trial of adjuvant chemotherapy with uracil-tegafur for adenocarcinoma of the lung. N Engl J Med 350 (2004) 1713-1721
    • (2004) N Engl J Med , vol.350 , pp. 1713-1721
    • Kato, H.1    Ichinose, Y.2    Ohta, M.3    Hata, E.4    Tsubota, N.5    Tada, H.6
  • 58
    • 0036225350 scopus 로고    scopus 로고
    • Low dose oral methotrexate and cyclophosphamide in metastatic breast cancer: antitumor activity and correlation with vascular endothelial growth factor levels
    • Colleoni M., Rocca A., Sandri M.T., Zorzino L., Masci G., Nole F., et al. Low dose oral methotrexate and cyclophosphamide in metastatic breast cancer: antitumor activity and correlation with vascular endothelial growth factor levels. Ann Oncol 13 (2002) 73-80
    • (2002) Ann Oncol , vol.13 , pp. 73-80
    • Colleoni, M.1    Rocca, A.2    Sandri, M.T.3    Zorzino, L.4    Masci, G.5    Nole, F.6
  • 59
    • 33747032320 scopus 로고    scopus 로고
    • Randomized phase II trial of letrozole and letrozole plus low-dose metronomic oral cyclophosphamide as primary systemic treatment in elderly breast cancer patients
    • Bottini A., Generali D., Brizzi M.P., Fox S.B., Bersiga A., Bonardi S., et al. Randomized phase II trial of letrozole and letrozole plus low-dose metronomic oral cyclophosphamide as primary systemic treatment in elderly breast cancer patients. J Clin Oncol 24 (2006) 3623-3628
    • (2006) J Clin Oncol , vol.24 , pp. 3623-3628
    • Bottini, A.1    Generali, D.2    Brizzi, M.P.3    Fox, S.B.4    Bersiga, A.5    Bonardi, S.6
  • 60
    • 2542539735 scopus 로고    scopus 로고
    • A comparative analysis of low dose metronomic cyclophosphamide reveals absent or low grade toxicity on tissues highly sensitive to the toxic effects of maximum tolerated dose regimens
    • Emmenegger U., Man S., Shaked Y., Francia G., Wong J.W., Hicklin D.J., et al. A comparative analysis of low dose metronomic cyclophosphamide reveals absent or low grade toxicity on tissues highly sensitive to the toxic effects of maximum tolerated dose regimens. Cancer Res 64 (2004) 3994-4000
    • (2004) Cancer Res , vol.64 , pp. 3994-4000
    • Emmenegger, U.1    Man, S.2    Shaked, Y.3    Francia, G.4    Wong, J.W.5    Hicklin, D.J.6
  • 61
    • 0037687355 scopus 로고    scopus 로고
    • Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741
    • Citron M.L., Berry D.A., Cirrincione C., Hudis C., Winer E.P., Gradishar W.J., et al. Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741. J Clin Oncol 21 (2003) 1431-1439
    • (2003) J Clin Oncol , vol.21 , pp. 1431-1439
    • Citron, M.L.1    Berry, D.A.2    Cirrincione, C.3    Hudis, C.4    Winer, E.P.5    Gradishar, W.J.6
  • 62
    • 0036031829 scopus 로고    scopus 로고
    • G-CSF stimulates angiogenesis and promotes tumor growth: potential contribution of bone marrow-derived endothelial progenitor cells
    • Natori T., Sata M., Washida M., Hirata Y., Nagai R., and Makuuchi M. G-CSF stimulates angiogenesis and promotes tumor growth: potential contribution of bone marrow-derived endothelial progenitor cells. Biochem Biophys Res Commun 297 (2002) 1058-1061
    • (2002) Biochem Biophys Res Commun , vol.297 , pp. 1058-1061
    • Natori, T.1    Sata, M.2    Washida, M.3    Hirata, Y.4    Nagai, R.5    Makuuchi, M.6
  • 63
    • 36849013036 scopus 로고    scopus 로고
    • Bv8 regulates myeloid-cell-dependent tumour angiogenesis
    • Shojaei F., Wu X., Zhong C., Yu L., Liang X.H., Yao J., et al. Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature 450 (2007) 825-831
    • (2007) Nature , vol.450 , pp. 825-831
    • Shojaei, F.1    Wu, X.2    Zhong, C.3    Yu, L.4    Liang, X.H.5    Yao, J.6
  • 64
    • 34548423732 scopus 로고    scopus 로고
    • Influence of formulation vehicle on metronomic taxane chemotherapy: albumin-bound versus cremophor EL-based paclitaxel
    • Ng S.S.W., Sparreboom A., Shaked Y., Lee C., Man S., Desai N., et al. Influence of formulation vehicle on metronomic taxane chemotherapy: albumin-bound versus cremophor EL-based paclitaxel. Clin Cancer Res 12 (2006) 4331-4338
    • (2006) Clin Cancer Res , vol.12 , pp. 4331-4338
    • Ng, S.S.W.1    Sparreboom, A.2    Shaked, Y.3    Lee, C.4    Man, S.5    Desai, N.6
  • 65
    • 0242331613 scopus 로고    scopus 로고
    • Thrombospondin-1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy
    • Bocci G., Francia G., Man S., Lawler J., and Kerbel R.S. Thrombospondin-1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy. Proc Natl Acad Sci USA 100 (2003) 12917-12922
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12917-12922
    • Bocci, G.1    Francia, G.2    Man, S.3    Lawler, J.4    Kerbel, R.S.5
  • 66
    • 1642368865 scopus 로고    scopus 로고
    • Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression
    • Hamano Y., Sugimoto H., Soubasakos M.A., Kieran M., Olsen B.R., Lawler J., et al. Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression. Cancer Res 64 (2004) 1570-1574
    • (2004) Cancer Res , vol.64 , pp. 1570-1574
    • Hamano, Y.1    Sugimoto, H.2    Soubasakos, M.A.3    Kieran, M.4    Olsen, B.R.5    Lawler, J.6
  • 67
    • 33749416983 scopus 로고    scopus 로고
    • Trastuzumab in combination with metronomic cyclophosphamide and methotrexate in patients with HER-2 positive metastatic breast cancer
    • Orlando L., Cardillo A., Ghisini R., Rocca A., Balduzzi A., Torrisi R., et al. Trastuzumab in combination with metronomic cyclophosphamide and methotrexate in patients with HER-2 positive metastatic breast cancer. BMC Cancer 6 (2006) 225
    • (2006) BMC Cancer , vol.6 , pp. 225
    • Orlando, L.1    Cardillo, A.2    Ghisini, R.3    Rocca, A.4    Balduzzi, A.5    Torrisi, R.6
  • 68
    • 58149402438 scopus 로고    scopus 로고
    • Costly cancer drug offers hope, but also a dilemma
    • Kolata G., and Pollack A. Costly cancer drug offers hope, but also a dilemma. New York Times (2008 Jul 6)
    • (2008) New York Times
    • Kolata, G.1    Pollack, A.2
  • 69
    • 33746548452 scopus 로고    scopus 로고
    • Predicting benefit from anti-angiogenic agents in malignancy
    • Jubb A.M., Oates A.J., Holden S., and Koeppen H. Predicting benefit from anti-angiogenic agents in malignancy. Nat Rev Cancer 6 (2006) 626-635
    • (2006) Nat Rev Cancer , vol.6 , pp. 626-635
    • Jubb, A.M.1    Oates, A.J.2    Holden, S.3    Koeppen, H.4
  • 70
    • 53749093040 scopus 로고    scopus 로고
    • Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100
    • Schneider B.P., Wang M., Radovich M., Sledge G.W., Badve S., Thor A., et al. Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100. J Clin Oncol 26 (2008) 4672-4678
    • (2008) J Clin Oncol , vol.26 , pp. 4672-4678
    • Schneider, B.P.1    Wang, M.2    Radovich, M.3    Sledge, G.W.4    Badve, S.5    Thor, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.