Fascia: A missing link in our understanding of the pathology of fibromyalgia

Journal of Bodywork and Movement Therapies

Volumn 14, Issue 1, 2010, Pages 3-12

  Liptan, Ginevra L ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b Legacy Good Samaritan Pain Management Center   (United States)

Author keywords

Central sensitization; Connective tissue; Growth hormone; Inflammation; Manual therapy; Myofascial release

Indexed keywords

COLLAGEN; CORTICOSTEROID; CYTOKINE; GROWTH HORMONE; IBUPROFEN; INTERLEUKIN 6; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; PREDNISONE;

ADHESION; ARTICLE; CONNECTIVE TISSUE; CYTOKINE RELEASE; DISEASE COURSE; DRUG EFFICACY; DRUG MEGADOSE; FASCIA; FIBROBLAST; FIBROMYALGIA; FIBROSIS; HORMONE SYNTHESIS; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INFLAMMATION; INNERVATION; MANIPULATIVE MEDICINE; MUSCLE CELL; NERVE EXCITABILITY; NERVE STIMULATION; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; OSTEOPATHIC MEDICINE; SENSITIZATION; SLEEP DISORDER; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; COLLAGEN; FASCIA; FIBROBLASTS; FIBROMYALGIA; GROWTH HORMONE; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; MANIPULATION, OSTEOPATHIC; SLEEP DISORDERS;

EID: 72049106920     PISSN: 13608592     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbmt.2009.08.003     Document Type: Article

References (89)

1. Adler G.K., Kinsley B.T., Hurwitz S., Mossey C.J., and Goldenberg D.L. Reduced hypothalamic-pituitary and sympathoadrenal responses to hypoglycemia in women with fibromyalgia syndrome. The American Journal of Medicine 106 (1999) 534-543
2. Al-Allaf A.W., Dunbar K.L., and Hallum N.S. A case-control study examining the role of physical trauma in the onset of fibromyalgia syndrome. Rheumatology (Oxford) 41 (2002) 450-453
3. Almekinders L.C., and Gilbert J.A. Healing of experimental muscle strains and the effects of nonsteroidal antiinflammatory medication. American Journal of Sports Medicine 14 4 (1986) 303-308
4. Almekinders L.C., Baynes A.J., and Bracey L.W. An in vitro investigation into the effects of repetitive motion and nonsteroidal antiinflammatory medication on human tendon fibroblasts. American Journal of Sports Medicine 23 1 (1995) 119-124
5. Arnold L.M., Hudson J.J., Hess E.V., et al. Family study of fibromyalgia. Arthritis & Rheumatism 50 (2004) 944-952
6. Astrom M., and Westlin N. No effect of piroxicam on achilles tendinopathy. A randomized study of 70 patients. Acta Orthopaedica Scandinavica 63 6 (1992) 631-634
7. Bajaj P., Bajaj P., Madsen H., and Arendt-Nielson L. Endometriosis is associated with central sensitization: a psychophysical controlled study. The Journal of Pain 4 7 (2003) 372-380
8. Bartels E.M., and Danneskold-Samsoe B. Histological abnormalities in muscle from patients with certain types of fibrositis. Lancet 1 8484 (1986) 755-757
9. Beckert S., Haack S., Hierlemann H., et al. Stimulation of steroid-suppressed cutaneous healing by repeated topical application of IGF-1: different mechanisms of action based on mode of IGF-1 delivery. Journal of Surgical Research 139 2 (2007) 217-221
10. Bednar D.A., Orr F.W., and Simon G.T. Observations on the pathomorphology of the thoracolumbar fascia in chronic mechanical back pain. Spine 20 10 (1995) 1161-1164
11. Bennett R.M., Clark S.R., Campbell S.M., and Burkhardt C.S. Low levels of somatomedin-C in patients with the fibromyalgia syndrome: a possible link between sleep and muscle pain. Arthritis & Rheumatism 35 10 (1992) 1113-1116
12. Bennett R.M., Clark S.C., and Walczyk J. A randomized, double-blind, placebo-controlled study of growth hormone in the treatment of fibromyalgia. American Journal of Medicine 104 3 (1998) 227-231
13. Bennett R.M. Fibromyalgia: present to future. Current Pain and Headache Reports 8 (2004) 379-384
14. Bissett L., Beller E., Jull G., et al. Mobilisation with movement and exercise, corticosteroid injection, or wait and see for tennis elbow: randomized trial. British Journal of Medicine 333 7575 (2006) 939
15. Bonica J.J. The Management of Pain (1990), Lea & Febinger, Philadelphia p. 34
16. Brattberg G. Connective tissue massage in the treatment of fibromyalgia. European Journal of Pain 3 (1999) 235-245
17. Buckley C.D., Pilling D., Lord J.M., et al. Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation. Trends in Immunology 22 4 (2001) 199-204
18. Chaitow L., and DeLany J.W. Clinical Applications of Neuromuscular Techniques (2000), Churchill Livingstone, London p. 3
19. Clark S., Tindall E., and Bennett R.M. A double blind crossover trial of prednisone versus placebo in the treatment of fibrositis. Journal of Rheumatology 12 5 (1985) 980-983
20. Cohen H., Neumann L., Shore M., Amir M., Cassuto Y., and Buskila D. Autonomic dysfunction in fibromyalgia: application of a power spectral analysis of heart rate variability. Seminars in Arthritis and Rheumatism 29 (2000) 217-227
21. Collins D. Fibrositis and infection. Annals of the Rheumatic Diseases 2 (1940) 114-126
22. Crawford F., Atkins D., Young P., et al. Steroid injection for heel pain: evidence for short-term effectiveness. A randomized controlled trial. Rheumatology (Oxford) 38 10 (1999) 974-977
23. Cuneo R.C., Judd S., Wallace J.D., et al. The Australian multicenter trial of growth hormone (GH) treatment in GH-deficient adults. Journal of Clinical Endocrinology & Metabolism 83 1 (1998) 107-116
24. Danto J.B. Review of integrated neuromusculoskeletal release and the novel application of a segmental anterior/posterior approach in the thoracic, lumbar, and sacral regions. Journal of the American Osteopathic Association 103 12 (2003) 583-596
25. Dickenson A.H., and Sullivan A.F. Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurons following C fibre stimulation. Neuropharmacology 26 (1987) 1235-1238
26. Dodd J.G., Good M.M., Nguyen T.L., Grigg A.I., Batia L.M., and Standley P.R. In vitro biophysical strain model for understanding mechanisms of osteopathic manipulative treatment. Journal of the American Osteopathic Association 106 3 (2006) 157-166
27. Donley B.G., Moore T., Sferra S., et al. The efficacy of oral nonsteroidal anti-inflammatory medication (NSAID) in the treatment of plantar fasciitis: a randomized, prospective, placebo-controlled study. Foot & Ankle International 28 1 (2007) 20-23
28. Drewes A.M., Andreasen A., Schroder H.D., et al. Pathology of skeletal muscle in fibromyalgia: a histo-immuno-chemical and ultrastructural study. British Journal of Rheumatology 32 6 (1993) 479-483
29. Felig P., Baxter J.D., and Frohman L.A. Endocrinology and Metabolism (1995), McGraw-Hill, New York p. 307
30. Franklyn-Miller A., Falvey E., and McCrory P. Fasciitis first before tendinopathy; does the anatomy hold the key?. British Journal of Sports Medicine (2009) (epub ahead of print)
31. Gamber R.G., Shores J.H., Russo D.P., Jimenez C., and Rubin B.R. Osteopathic manipulative treatment in conjunction with medication relieves pain associated with fibromyalgia syndrome: results of a randomized clinical pilot project. Journal of the American Osteopathic Association 102 6 (2002) 321-325
32. Giesecke T., Gracely R.H., Grant M.A.B., et al. Evidence of augmented central pain processing in idiopathic chronic low back pain. Arthritis & Rheumatism 50 2 (2004) 613-623
33. Gilpin D.A., Barrow R.E., Rutan R.L., et al. Recombinant human growth hormone accelerates wound healing in children with large cutaneous burns. Annals of Surgery 220 1 (1994) 19-24
34. Goldenberg, D.L., Felson, D.T., Dinerman, H., 1986. A randomized controlled trial of amitriptyline and naproxen in the treatment of patients with fibromyalgia. 29, 1371-1377.
35. Gowers W. Lumbago: its lessons and analogues. British Medical Journal 1 (1904) 117-121
36. Gracely R., Petzke F., Wolf J., and Clauw D. Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia. Arthritis & Rheumatism 46 5 (2002) 1333-1343
37. Granges G., and Littlejohn G. Prevalence of myofascial pain syndrome in fibromyalgia syndrome and regional pain syndrome: a comparative study. Journal of Musculoskeletal Pain 1 (1993) 19-35
38. Grimm D. Cell biology meets Rolfing. Science 318 (2007) 1234-1235
39. Green A.P., and Mangan F.R. The effect of steroidal and non-steroidal anti-inflammatory drugs on chronic muscle inflammation. Journal of Pharmacy and Pharmacology 32 (1980) 319-322
40. Heere L.P. Piroxicam in acute musculoskeletal disorders and sports injuries. European Journal of Rheumatology and Inflammation 8 1 (1987) 60-64
41. Herndon D.N., Hawkins H.K., Nguyen T.T., et al. Characterization of growth hormone enhanced donor site healing in patients with large cutaneous burns. Annals of Surgery 221 6 (1995) 649-659
42. Jarde O., Diebold P., Havet E., et al. Degenerative lesions of the plantar fascia: surgical treatment by fasciectomy and excision of the heel spur. A report on 38 cases. Acta Orthopaedica Belgica 69 3 (2003) 267-274
43. Ji R.R., Kohno T., Moore K.A., and Woolf C.J. Central sensitization and LTP: do pain and memory share similar mechanisms?. Trends in Neurosciences 26 12 (2003) 696-705
44. Jones K.D., Deodhar P., Lorentzen A., et al. Growth hormone perturbations in fibromyalgia: a review. Seminars in Arthritis and Rheumatism 36 6 (2007) 357-379
45. Kalluri R., and Zeisberg M. Fibroblasts in cancer. Nature Reviews Cancer 6 5 (2006) 392-401
46. Kosek E., and Ordeberg G. Abnormalities of somatosensory perception in patients with painful osteoarthritis normalize following successful treatment. European Journal of Pain 4 3 (2000) 229-238
47. Kraushaar B.S., and Nirschl R.P. Tendinosis of the elbow (tennis elbow): clinical features and findings of histological, immunohistochemical and electron micrsocopy studies. The Journal of Bone and Joint Surgery 81 2 (1999) 259-278
48. Kumar S. Biomechanics in Ergonomics (1999), Taylor & Francis, Philadelphia p. 36
49. Landis C., Lentz M., Rothermel J., et al. Decreased nocturnal levels of prolactin and growth hormone in women with fibromyalgia. The Journal of Clinical Endocrinology & Metabolism 86 4 (2001) 1672-1678
50. Lang P.M., Schober G.M., Rolke R., et al. Sensory neuropathy and signs of central sensitization in patients with peripheral arterial disease. Pain 124 1-2 (2006) 190-200
51. Langevin H.M. Potential role of fascia in chronic musculoskeletal pain. In: Audette, and Bailey (Eds). Integrative Pain Medicine (2008), Humana Press 125
52. Langevin, H.M., Stevens-Tuttle, D., Fox, J.R., et al., 2009. Ultrasound evidence of altered lumbar connective tissue structure in human subjects with chronic low back pain. Abstract only. Fascia Research Congress.
53. Leal-Cerro A., Povedano J., Astorga R., et al. The growth hormone (GH)-releasing hormone-GH-insulin-like growth factor-1 axis in patients with fibromyalgia syndrome. The Journal of Clinical Endocrinology & Metabolism 84 9 (1999) 3378-3381
54. Lindh M., Johansson G., Hedberg M., et al. Muscle fiber characteristics, capillaries and enzymes in patients with fibromyalgia and controls. Scandinavian Journal of Rheumatology 24 1 (1995) 34-37
55. Miagkov A.V., Kovalenko D.V., Brown C.E., et al. NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint. Proceedings of the National Academy of Sciences of the United States of America 95 (1998) 13859-13864
56. Moldofsky H., Scarisbrick P., England R., and Smythe H. Musculoskeletal symptoms and non-REM sleep disturbance in patients with fibrositis and healthy subjects. Psychosomatic Medicine 37 (1975) 341-351
57. Moldofsky H., and Scarisbrick P. Induction of neurasthenic musculoskeletal pain syndrome by selective sleep stage deprivation. Psychosomatic Medicine 38 1 (1976) 35-44
58. Murphy K.D., Rose M.W., Chinkes D.L., et al. The effects of gamma-hydroxybutyrate on hypermetabolism and wound healing in a rat model of large thermal injury. Journal of Trauma 63 5 (2007) 1099-1107
59. Murphy L.J., Vrhovsek E., and Lazarus L. Identification and characterization of specific growth hormone receptors in cultured human fibroblasts. Journal of Clinical Endocrinology & Metabolism 57 6 (1983) 1117-1124
60. Oakes S.R., Haynes K.M., Waters M.J., et al. Demonstration and localization of growth hormone receptors in human skin and skin fibroblasts. Journal of Clinical Endocrinology & Metabolism 75 5 (1992) 1368-1373
61. Obremsky W.T., Seaber A.V., Ribbeck B.M., et al. Biomechanical and histologic assessment of a controlled muscle strain injury treated with piroxicam. American Journal of Sports Medicine 22 4 (1994) 558-561
62. O'Neill S., Manniche C., Graven-Nielsen T., and Arendt-Nielsen L. Generalized deep-tissue hyperalgesia in patients with chronic low-back pain. European Journal of Pain 11 4 (2007) 415-420
63. Paiva E.S., Deodhar A., Jones K.D., and Bennett R. Impaired growth hormone secretion in fibromyalgia patients: evidence for augmented hypothalamic somatostatin tone. Arthritis & Rheumatism 46 5 (2002) 1344-1350
64. Russell I.J., Perkins A.T., and Michalek J.E. Sodium oxybate relieves pain and improves function in fibromyalgia syndrome. Arthritis & Rheumatism 60 1 (2009) 299-309
65. Ruster M., Franke S., Spaeth M., et al. Detection of elevated N-carboxymethyllysine levels in muscular tissue and serum of patients with fibromyalgia. Scandinavian Journal of Rheumatology 34 6 (2005) 460-463
66. Schiffman E.L., Fricton J.R., and Haley D.P. The prevalence and treatment needs of subjects with temporomandibular disorders. Journal of the American Dental Association 120 (1990) 295-303
67. Schleip R., Klingler W., and Lehmann-Horn F. Active fascial contractility: fascia may be able to actively contract in a smooth muscle-like manner and thereby influence musculoskeletal dynamics. Medical Hypotheses 65 (2005) 273-277
68. Schleip R., Lehmann-Horn F., and Klingler W. Fascia is able to contract in a smooth muscle-like manner and thereby influence musculoskeletal mechanics. Proceedings of the 5th World Congress of Biomechanics (2006) 51-54 Munich, Germany
69. Shah J., Phillips T., Danoff J., and Gerber L. An in vivo microanalytical technique for measuring the local biochemical milieu of human skeletal muscle. Journal of Applied Physiology 99 (2005) 1977-1984
70. Simms R. Is there muscle pathology in fibromyalgia syndrome?. Rheumatic Disease Clinics of North America 22 2 (1996) 245-266
71. Simons D.G., Travell J.G., and Simons L.S. Myofascial Pain and Dysfunction: The Trigger Point Manual vol. 1 (1999), Lippincott Williams & Wilkins, Baltimore p. 19
72. Skutek M., van Griensven M., Zeichen J., et al. Cyclic mechanical stretching enhances secretion of interleukin 6 in human tendon fibroblasts. Knee Surgery, Sports Traumatology, Arthroscopy 9 5 (2001) 322-326
73. Sola A.E., Rodenberger M.L., and Gettys B.B. Incidence of hypersensitive areas in posterior shoulder muscles. American Journal of Physical Medicine 34 (1955) 585-590
74. Sorensen J., Graven-Nieslen T., Henriksson K.G., et al. Hyperexcitability in fibromyalgia. Journal of Rheumatology 25 1 (1998) 152-155
75. Spaeth M., Fischer P., Lagner C., and Pongratz D. Increase of collagen IV in skeletal muscle of fibromyalgia patients. Journal of Musculoskeletal Pain 12 9S (2005) 67
76. Starz, T.W., Vogt, M., Gold, K., 2008. Fibromyalgia: what's tender, what's not. In: American College Rheumatology 2008 Annual Scientific Meeting, abstract 1405.
77. Staud R., Price D.D., Robinson M.E., et al. Maintenance of windup of second pain requires less frequent stimulation in fibromyalgia patients compared to normal controls. Pain 110 3 (2004) 689-696
78. Staud R. The role of peripheral input for chronic pain syndromes like fibromyalgia syndrome. Journal of Musculoskeletal Pain 16 1 & 2 (2008) 67-74
79. Stecco C., Porzionaato A., Macchi V., Tiengo C., Parenti A., Aldegheri R., Delmas V., and De Caro R. A histological study of the deep fascia of the upper limb. Italian Journal of Anatomy and Embryology 11 2 (2006) 1-6
80. Stockman R. The causes, pathology and treatment of chronic rheumatism. Edinburgh Medical Journal 15 107-116 (1904) 223-235
81. Suh D.Y., Hunt T.K., and Spencer E.M. Insulin-like growth factor-1 reverses the impairment of wound healing induced by corticosteroids in rats. Endocrinology 131 5 (1992) 2399-2403
82. Todorovic V., Pesko P., and Micev M. Insulin-like growth factor-1 in wound healing of rat skin. Regulatory Peptides 150 1-3 (2008) 7-13
83. Wall P.D., and Woolf C.J. Muscle but not cutaneous C-afferent input produces prolonged increases in the excitability of the flexion reflex in the rat. The Journal of Physiology (London) 356 (1984) 453-458
84. Ward R.C. Foundations for Osteopathic Medicine (2003), Lippincott, Williams & Wilkins, Philadelphia p. 1158
85. Watkins L.R., Milligan E.D., and Maier S.F. Glial activation: a driving force for pathological pain. Trends in Neurosciences 24 8 (2001) 450-455
86. Wolfe F., Smythe H.A., Yunus M.B., et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Arthritis & Rheumatism 33 2 (1990) 160-172
87. Wolfe F., Simons D.G., Fricton J., et al. The fibromyalgia and myofascial pain syndrome: a preliminary study of tender points and trigger points in persons with fibromyalgia, myofascial pain syndrome and no disease. Journal of Rheumatology 19 6 (1992) 944-951
88. Yunus M.B., Kalyan-Raman U.P., Masi A.T., and Aldag J.C. Electron microscopic studies of muscle biopsy in primary fibromyalgia syndrome: a controlled and blinded study. Journal of Rheumatology 16 (1989) 97-101
89. Yunus M.B., Masi A.T., and Aldaq J.C. Short term effects of ibuprofen in primary fibromyalgia syndrome: a double blind, placebo controlled trial. Journal of Rheumatology 16 4 (1989) 527-532