Acanthosis Nigricans Identifies Youth at High Risk for Metabolic Abnormalities

Journal of Pediatrics

Volumn 156, Issue 1, 2010, Pages 87-92

  Brickman, Wendy J ^a,b   Huang, Jie ^b   Silverman, Bernard L ^c   Metzger, Boyd E ^b  

^a CHILDREN'S MEMORIAL HOSPITAL   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c ALKERMES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; GLUTAMATE DECARBOXYLASE ANTIBODY; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TESTOSTERONE; TRIACYLGLYCEROL;

ACANTHOSIS NIGRICANS; ACNE; ADOLESCENT; AFRICAN AMERICAN; ANTHROPOMETRY; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD SAMPLING; BODY MASS; CARBOHYDRATE DIET; CHILD; CHOLESTEROL BLOOD LEVEL; CLINICAL ASSESSMENT; CONTROLLED STUDY; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; FEMALE; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE TEST; HIGH RISK POPULATION; HIRSUTISM; HISPANIC; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; JUVENILE; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MENSTRUAL IRREGULARITY; METABOLIC DISORDER; ORAL GLUCOSE TOLERANCE TEST; OVARY POLYCYSTIC DISEASE; PHYSICAL EXAMINATION; PRIORITY JOURNAL; QUESTIONNAIRE; SCHOOL CHILD; SYSTOLIC BLOOD PRESSURE;

ACANTHOSIS NIGRICANS; ADOLESCENT; BLOOD GLUCOSE; CHILD; FEMALE; HOMEOSTASIS; HUMANS; INSULIN RESISTANCE; MALE; MULTIVARIATE ANALYSIS; OBESITY; PREVALENCE; RISK ASSESSMENT;

EID: 72049104429     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpeds.2009.07.011     Document Type: Article

References (20)

1. Pinhas-Hamiel O., Dolan L.M., Daniels S.R., Standiford D., Khoury P.R., and Zeitler P. Increased incidence of non-insulin-dependent diabetes mellitus among adolescents. J Pediatr 128 (1996) 608-615
2. Fagot-Campagna A., Pettitt D.J., Engelgau M.M., Burrows N.R., Geiss L.S., Valdez R., et al. Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective. J Pediatr 136 (2000) 664-672
3. Sellers E.A., Yung G., and Dean H.J. Dyslipidemia and other cardiovascular risk factors in a Canadian First Nation pediatric population with type 2 diabetes mellitus. Pediatr Diabetes 8 (2007) 384-390
4. Goran M.I., Bergman R.N., Avila Q., Watkins M., Ball G.D., Shaibi G.Q., et al. Impaired glucose tolerance and reduced beta-cell function in overweight Latino children with a positive family history for type 2 diabetes. J Clin Endocrinol Metab 89 (2004) 207-212
5. Sinha R., Fisch G., Teague B., Tamborlane W.V., Banyas B., Allen K., et al. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 346 (2002) 802-810
6. Copeland K., Pankratz K., Cathey V., Immohotichey P., Maddox J., Felton B., et al. Acanthosis Nigricans, insulin resistance (HOMA) and dyslipidemia among Native American children. J Okla State Med Assoc 99 (2006) 19-24
7. Brickman W.J., Binns H.J., Jovanovic B.D., Kolesky S., Mancini A.J., Metzger B.E., et al. Acanthosis nigricans: a common finding in overweight youth. Pediatr Dermatol 24 (2007) 601-606
8. Burke J.P., Hale D.E., Hazuda H.P., and Stern M.P. A quantitative scale of acanthosis nigricans. Diabetes Care 22 (1999) 1655-1659
9. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and A. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and A. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 114 (2004) 555-576
10. Hickman T.B., Briefel R.R., Carroll M.D., Rifkind B.M., Cleeman J.I., Maurer K.R., et al. Distributions and trends of serum lipid levels among United States children and adolescents ages 4-19 years: data from the Third National Health and Nutrition Examination Survey. Prev Med 27 (1998) 879-890
11. American Diabetes A., and American Diabetes A. Diagnosis and classification of diabetes mellitus. Diabetes Care 31 Suppl 1 (2008) S55-S60
12. American Diabetes A., and American Diabetes A. Standards of medical care in diabetes-2008. Diabetes Care 31 Suppl 1 (2008) S12-S54
13. Marcovina S.M., Landin-Olsson M., Essen-Moller A., Palmer J.P., and Lernmark A. Evaluation of a novel radioimmunoassay using 125I-labelled human recombinant GAD65 for the determination of glutamic acid decarboxylase (GAD65) autoantibodies. Int J Clin Lab Res 30 (2000) 21-26
14. Palmert M.R., Gordon C.M., Kartashov A.I., Legro R.S., Emans S.J., and Dunaif A. Screening for abnormal glucose tolerance in adolescents with polycystic ovary syndrome. J Clin Endocrinol Metab 87 (2002) 1017-1023
15. Reinehr T., Schober E., Wiegand S., Thon A., and Holl R. DPV-Wiss Study Group Beta-cell autoantibodies in children with type 2 diabetes mellitus: subgroup or misclassification?. Arch Dis Child 91 (2006) 473-477
16. Rosenbloom A.L., Silverstein J.H., Amemiya S., Zeitler P., and Klingensmith G.J. ISPAD Clinical Practice Consensus Guideline 2006-2007. Type 2 diabetes mellitus in the child and adolescent. Pediatr Diabetes 9 (2008) 512-526
17. Tfayli H., Bacha F., Gungor N., and Arslanian S. Phenotypic type 2 diabetes in obese youth: insulin sensitivity and insulin secretion in islet cell antibody-negative versus -positive patients. Diabetes 58 (2009) 738-744
18. Mukhtar Q., Cleverley G., Voorhees R.E., and McGrath J.W. Prevalence of acanthosis nigricans and its association with hyperinsulinemia in New Mexico adolescents. J Adolesc Health 28 (2001) 372-376
19. Kobaissi H.A., Weigensberg M.J., Ball G.D., Cruz M.L., Shaibi G.Q., and Goran M.I. Relation between acanthosis nigricans and insulin sensitivity in overweight Hispanic children at risk for type 2 diabetes. Diabetes Care 27 (2004) 1412-1416
20. Nguyen T.T., Keil M.F., Russell D.L., Pathomvanich A., Uwaifo G.I., Sebring N.G., et al. Relation of acanthosis nigricans to hyperinsulinemia and insulin sensitivity in overweight African American and white children. J Pediatr 138 (2001) 474-480