Short-term effects of high dose estrogen on tibiae of growing male rats

Calcified Tissue International

Volumn 60, Issue 1, 1997, Pages 37-42

  Wakley, G K ^a,b   Evans, G L ^a   Turner, R T ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Bone formation; Bone histomorphometry; Bone resorption; Estrogen; Male rats

Indexed keywords

ESTROGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE ATROPHY; BONE GROWTH; BONE METABOLISM; CANCELLOUS BONE; CELL MATURATION; CONTROLLED STUDY; DRUG EFFECT; ESTROGEN METABOLISM; ESTROGEN THERAPY; METAPHYSIS; NONHUMAN; OSSIFICATION; OSTEOLYSIS; OSTEOPENIA; PRIORITY JOURNAL; RAT; TIBIA;

AGING; ANIMALS; BONE DEVELOPMENT; ESTROGENS; MALE; RATS; SEX FACTORS; TIBIA;

EID: 0031028594     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002239900183     Document Type: Article

References (45)

1. Silberberg M, Silberberg R (1971) Steroid hormones and bone. In: Bourne GH (ed) The biochemistry and physiology of bone, vol. III. Academic Press, NY, pp 401-484
2. Turner RT, Vandeersteenhoven JJ, Bell NH (1987) The effects of ovariectomy and 17β-estradiol on cortical bone histomorphometry in growing rats. J Bone Miner Res 2:115-122
3. Kalu DK, Liu CC, Hardin RR, Hollis BW (1989) The aged rat model of ovarian hormone deficiency bone loss. Endocrinology 124:7-16
4. Turner RT, Wakley GK, Hannon KS, Bell NH (1987) Tamoxifen prevents the skeletal effects of ovarian hormone deficiency in rats. J Bone Miner Res 2:449-456
5. Wronski TJ, Cintron M, Dann LM (1988) Temporal relationship between bone loss and increased bone turnover in ovariectomized rats. Calcif Tissue Res 43:179-183
6. Wronski TJ, Lowry PL, Walsh CC, Ignaszewski LA (1985) Skeletal alterations in ovariectomized rats. Calcif Tissue Int 37:324-328
7. Wronski TJ, Cintron M, Doherty AL, Dann LM (1988) Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats. Endocrinology 123:681-686
8. Moon LY, Wakley GK, Turner RT (1991) Dose-dependent effects of tamoxifen on long bones in growing rats: influence of ovarian status. Endocrinology 129:1568-1574
9. Wronski TJ, Dann LM, Scott KS, Crooke LR (1989) Endocrine and pharmacological suppressors of bone turnover protect against osteopenia in ovariectomized rats. Endocrinology 125:810-816
10. Kalu DN, Liu CC, Salerno E, Hollis B, Echon R, Ray M (1991) Skeletal response of ovariectomized rats to low and high doses of 17 beta-estradiol. Bone Miner 14:175-187.
11. Takano-Yamamoto T, Rodan GA (1990) Direct effects of 17β-estradiol on trabecular bone in ovariectomized rats. Proc Natl Acad Sci 87:2172-2176
12. Somjen D, Weisman Y, Harell A, Berger E, Kaye AM (1989) Direct and sex-specific stimulation by sex steroids of creatinine kinase activity and DNA synthesis in rat bone. Proc Natl Acad Sci USA 86:3361-3365
13. Abe T, Chow JWM, Lean JM, Chambers TJ (1992) The anabolic action of 17β-estradiol (E2) on rat trabecular bone is suppressed by (3-amino-1-hydroxypropylidene)-1-bisphosphonate (AHPrBP). Bone Miner 19:21-29
14. Chow JWM, Lean JM, Chambers TJ (1992) 17β-estradiol stimulates cancellous bone formation in female rats. Endocrinology 130:3025-3032
15. Chow JWM, Tobias JH, Colston KW, Chambers TJ (1992) Estrogen maintains trabecular bone volume in rats not only by suppression of bone resorption but also by stimulation of bone formation. J Clin Invest 89:74-78
16. Tobias JH, Chow JWM, Colston KW, Chambers TJ (1991) High concentrations of 17β-estradiol stimulate trabecular bone formation in adult female rats. Endocrinology 128:408-412
17. Vanderschueren D, VanHerck E, Suiker AM, Visser WJ, Schot LP, Bouillon R (1992) Bone and mineral metabolism in aged male rats: short- and long-term effects of androgen deficiency. Endocrinology 130:2906-2916
18. Döhler KD, Wuttke W (1975) Changes with age in levels of serum gonadotropins, prolactin and gonadal steroids in prepubertal male and female rats. Endocrinology 97:898-907
19. Schweikert HU, Rulf W, Niederle N, Schäer HE, Keck E, Kruck F (1980) Testosterone metabolism in human bone. Acta Endocrinol (Copenh) 95:258-264
20. Vittek J, Altman K, Gordon GG, Southren AL (1974) The metabolism of 7 alpha-3H-testosterone by rat mandibular bone. Endocrinology 94:325-329
21. Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, Williams TC, Lubahn DB, Korach KS (1994) Estrogen resistance caused by a mutation in the estrogen-receptor gene in man. N Engl J Med 331:1056-1061
22. Conte FA, Grumbach MM, Ito Y, Fisher CR, Simpson ER (1994) A syndrome of female pseudohermaphrodism, hypergonadotrophic hypergonadism, and multicystic ovaries associated wtih missense mutations in the gene encoding aromatose. J Clin Endocrinol Metab 78:1287-1292
23. Turner RT, Hannon KS, Demers LM, Buchanan J, Bell NH (1989) Differential effects of gonadal function on bone histomorphometry in male and female rats. J Bone Miner Res 4:557-563
24. Turner RT, Wakley GK, Hannon KS (1990) Differential effects of androgens on cortical bone histomorphometry in gonadectomized male and female rats. J Orthop Res 8:612-617
25. Wakley GK, Schutte DH, Hannon KS, Turner RT (1991) Androgen treatment prevents loss of cancellous bone in the orchidectomized rat. J Bone Miner Res 6:325-330
26. Wakley GK, Baum BL, Hannon KS, Turner RT (1988) The effect of tamoxifen on the osteopenia induced by sciatic neurectomy in the rat: a histomorphometric study. Calcif Tissue Int 43:383-388
27. Kimmel DB, Jee WSS (1980) A quantitative histological analysis of the growing long bone metaphysis. Calcif Tissue Int 32:113-122
28. Turner GK, Evans GL, Wakley GK (1993) The mechanism of action of estrogen on cancellous bone balance in the tibiae of ovariectomized growing rats; inhibition of indices of formation and resorption. J Bone Miner Res 8:359-366
29. Polig E, Jee WSS (1987) Bone age and remodeling: a mathematical treatise. Calcif Tissue Int 41:130-136
30. Westerlind KC, Wakley GK, Evans GL, Turner RT (1993) Estrogen does not increase bone formation in growing rats. Endocrinology 133:2924-2934
31. Turner RT, Evans GL, Wakley GK (1994) Reduced chondroclast differentiation results in increased cancellous bone volume in estrogen-treated growing rats. Endocrinology 134: 461-466
32. DuCaju MV, Bleyaert S, OpDeBeeck L (1993) Groeiremming met oestrogenen bij constitutioneel te lange meisjes (Growth inhibition using estrogens in constitutionally tall girls). Acta Clinica Belgica 48:11-19
33. Moritake S, Yamamuro T, Yamada J (1986) Effects of sex hormones on congenital kyphosis in Ishibashi rats. Acta Orthop Scand 57:62-66
34. Urist MR, Budy AM, McLean FC (1948) Species differences in the reaction of the mammalian skeleton to estrogen. Proc Exp Biol Med 68:324-326
35. Budy AM, Urist MR, McLean FC (1952) The effect of estrogens on the growth apparatus of the bones of immature rats. Am J Pathol 28:1143-1167
36. Cassorla FG, Skerda MC, Valk IM, Hung W, Cutler GB, Loriaux DL (1984) The effects of sex steroids on ulnar growth during adolescence. J Clin Endocrinol Metab 58:717-720
37. Caruso-Nicoletti M, Cassorla F, Skerda M, Ross JL, Loriaux DL, Cutler GB (1985) Short-term, low dose estradiol accelerates ulnar growth in boys. J Clin Endocrinol Metab 61:896-898
38. Turner RT (1994) Cancellous bone turnover in growing rats: time-dependent changes in association between calcein label and osteoblasts. J Bone Miner Res 9:1419-1424
39. Dziewiatkowski DD, Bronner F, DiFerrante N, Archibald RM (1957) Some aspects of the metabolism of sulfate-S35 and calcium 45 in the metaphysis of mature rats. Influence of beta-estradiol benzoate. J Biophys Biochem Cytol 3:151-160
40. Lean JM, Chow JWM, Chambers TJ (1993) Estrogen induces bone formation on nonresorptive surfaces in the rat. Bone 14:297-302
41. Wergedal JE, Baylink DJ (1974) Electron microprobe measurements of bone mineralization rate in vivo. Am J Physiol 226:345-352
42. Evans G, Bryant HU, Magee D, Sato M, Turner RT (1994) The effects of raloxifene on tibia histomorphometry in ovariectomized rats. Endocrinology 134:2283-2288
43. Luthy IA, Begin D, Labrie F (1988) Mediation by the androgen receptor of the stimulatory and antiandrogenic actions of 17β-estradiol on the growth of androgen-sensitive Shionogi mammary carcinoma cells in culture. Endocrinology 123: 1418-1424
44. Lips P, Asscheman H, Uitewaal P, Netelenbos JC, Gooren L (1989) The effect of cross-gender hormonal treatment on bone metabolism in male-to-female transsexuals. J Bone Miner Res 4:657-662
45. Christiansen C, Christiansen MS, Larsen NE, Transbol I (1982) Pathophysiological mechanism of estrogen effect on bone metabolism: dose-response relationship in early postmenopausal women. J Clin Endocrinol Metab 55:1124-1130