Spinal cord compression and extramedullary hematopoiesis in young Egyptian β-thalassemia patients

Hemoglobin

Volumn 33, Issue 6, 2009, Pages 448-462

  Tantawy, Azza A G ^a   Adly, Amira A M ^a   Mahdy, Sameh A R ^b   Kamel, Ghada Z ^a  

^a Ain Shams University   (Egypt)

^b AIN SHAMS UNIVERSITY   (Egypt)

Author keywords

Thalassemia ( thal); Computed tomography (CT); Extramedullary hematopoiesis (EMH); Magnetic resonance imaging (MRI); Spinal cord compression (SCC)

Indexed keywords

FERRITIN; HEMOGLOBIN;

ADOLESCENT; ADULT; ARTICLE; BETA THALASSEMIA; BLOOD TRANSFUSION; CHELATION; CHILD; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; EXTRAMEDULLARY HEMATOPOIESIS; FEMALE; FERRITIN BLOOD LEVEL; HUMAN; INCIDENCE; LUMBOSACRAL SPINE; MAJOR CLINICAL STUDY; MALE; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRESCHOOL CHILD; RISK FACTOR; SCHOOL CHILD; SPINAL CORD COMPRESSION;

ADOLESCENT; ADULT; ANEMIA; BETA-THALASSEMIA; BLOOD TRANSFUSION; CHILD; FERRITINS; HEMATOPOIESIS, EXTRAMEDULLARY; HEMOGLOBINS; HEMOSIDEROSIS; HUMANS; MAGNETIC RESONANCE IMAGING; SPINAL CORD COMPRESSION; TOMOGRAPHY, X-RAY COMPUTED; YOUNG ADULT;

EID: 72049101888     PISSN: 03630269     EISSN: 1532432X     Source Type: Journal    
DOI: 10.3109/03630260903337451     Document Type: Article

References (24)

1. Rady MS, Baffico M, Khalifa AS, et al. Identification of Mediterranean b-thalassemia mutations by reverse dot-blot in Italians and Egyptians. Hemoglobin. 1997;21(1):59-69.
2. Omar A, Abdel Karim E, Gendy WE, Marzouk I, Wagdy M. Molecular basis of b-thalassemia in Alexandria. Egypt J Immunol. 2005;12(1):15-24.
3. El-Hashemite N, Petrou M, Khalifa AS, Heshmat NM, Rady MS, Delhanty JD. Identification of novel Asian Indian and Japanese mutations causing b-thalassemia in the Egyptian population. Hum Genet. 1997;99(2):271-274.
4. Tsitsapoulas P, Zevgaridis D, Tsitsopoulos P, Tsomidis C, Amagmastopoulos I, Marinopoulos D. Lumbar nerve root compression due to extramedullary hematopoiesis in a patient with thalassemia: Complete clinical regression with radiation therapy. J Neurosurg Spine. 2007;6(2):156-160.
5. Aliberti B, Patrikiou A, Terentiou A, Fragatou S, Papadimitriou A. Spinal cord compression due to extramedullary hematopoiesis in two patients with thalassemia: Complete regression with blood transfusion therapy. J Neurol. 2001;248(1):18-22.
6. Gologan R, Lupescu I, Bujar L, Ostroveanu D, Dumitrescu A, Stanescu D. Thoracic spinal cord compression secondary to extramedullary haematopoiesis in thalassemia intermedia successfully treated by local radiotherapy and hydroxyurea: A case report and review of the literature. HAEMA. (J Hellenic Soc Haematol.) 2005;8(4):667-674.
7. Hussein G, Fawzy M, Serafi TE, et al. Rapid detection of b-thalassemia alleles in Egypt using naturally or amplified created restriction sites and direct sequencing: A step in disease control. Hemoglobin. 2007;31(1):49-62.
8. Tsitouridis J, Stamos S, Hassapopoulou E, Tsitouridis K, Nikolopoulos P. Extramedullary paraspinal hematopoiesis in thalassemia: CT and MRI evaluation. Eur J Radiol. 1999;30(1):33-38.
9. Munn RK, Kramer CA, Arnold SM. Spinal cord compression due to extramedullary hematopoiesis in b-thalassemia intermedia. Int J Radiat Oncol Biol Phys. 1998;42(3):607-609.
10. Coskun E, Keskin A, Suzer T, Sermez Y, Kildaci T, Tahta K. Spinal cord compression secondary to extramedullary hematopoiesis in thalassemia intermedia. Eur Spine J. 1998;7(6):501-504.
11. Salehi SA, Koski T, Ondra SL. Spinal cord compression in b-thalassemia: Case report and review of the literature. Spinal Cord. 2004;42(2):117-123.
12. Cianciulli P, di Torrito TC, Sorrentino F, Sergiacomi L, Massa A, Amardori S. Hydroxyurea therapy in parpaparesis and cauda equine syndrome due to extramedullary haematopoiesis in thalassemia improvement in clinical and haematological parameters. Eur J Haematol. 2000;64(6):426-429.
13. Martina IS, van Doorn PA. Spinal cord compression due to extramedullary haematopoiesis in thalassemia: A case report and review of the literature. J Neurol. 1996;243(4):364-366.
14. Ghosh A, Das D, Sarkar D. Acute reversible paraplegia. An interesting haematological problem. J Indian Acad Clin Med. 2005;6(1):73-75.
15. Chehal A, Aoun E, Koussa S, Skoury H, Koussa S, Taher A. Hypertransfusion: A successful method of treatment in thalassemia intermedia patients with spinal cord compression secondary to extramedullary hematopoiesis. Spine. 2003;28(13):245-249.
16. Cunningham MJ, Macklin EA, Neufeld EJ, Cohen AR. Complications of b-thalassemia major in North America. Blood. 2004;104(1):34-39.
17. Gatto I, Terrana V, Biondi L. Compression sul midallo spinale da proliferazion di midallo asseo spazio epidural in ssagetto da malattia di cooley splenectomizato. Haematologica. 1954;38(1):61-76.
18. Tan T, Tsao J, Cheung F. Extramedullary haemopoiesis in thalassemia intermedia presenting as paraplegia. J Clin Neurosci. 2002;9(6):721-725.
19. Voskaridou E, Kyrtsonis MC, Terpos E, Skordili M, Theodorpoulos I, Bergele A. Bone resorption is increased in young adults with thalassaemia major. Br J Haematol. 2001;112(1):36-41.
20. Taher A, Isma'eel H, Cappellini MD. Thalassemia intermedia: revisited. Blood Cells Mol Dis. 2006;37(1):12-20.
21. Bielinski BK, Darbyshire P, Mathers L, et al. Impact of disordered puberty on bone density in b thalassaemia major. Br J Haematol. 2003;120(2):353-358.
22. Abdelrazik N, Ghanem H. Failure of puberty in Egyptian b thalassemic patients: Experience in north East Region-Dakahlia Province. Hematology. 2007;12(5):449-456.
23. Shamshirsaz AA, Bekheirnia R, Kamgar M, et al. Metabolic and endocrinologic complications in b thalassemia major: A multicenter study in Iran. BMC Endocr Disord.; 2003;3(1)4.
24. Taher A, Isma'eel H, Mehio G, et al. Prevalence of thromboembolic events among 8,860 patients with thalassaemia major and intermedia in the Mediterranean area and Iran. Thromb Haemost. 2006;96(4):488-491.