Discovery of dipiperidines as new antitubercular agents

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 1, 2010, Pages 201-205

  Bogatcheva, Elena ^a   Hanrahan, Colleen ^a   Chen, Ping ^a   Gearhart, Jacqueline ^a   Sacksteder, Katherine ^a   Einck, Leo ^a   Nacy, Carol ^a   Protopopova, Marina ^a  

^a SEQUELLA INC   (United States)

Author keywords

Antitubercular drugs; Dipiperidines; Tuberculosis

Indexed keywords

SQ 609; SQ 611; SQ 612; SQ 613; SQ 614; SQ 615; SQ 616; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL CELL; CONTROLLED STUDY; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANTITUBERCULAR AGENTS; DRUG DISCOVERY; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; PIPERIDINES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

MYCOBACTERIUM TUBERCULOSIS;

EID: 72049099589     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.10.135     Document Type: Article

References (11)

1. World Health Organization. Tuberculosis Facts 2009. http://www.who.int/tb/publications/2009/tbfactsheet_2009_one_page.pdf.
2. Rivers E.C., and Mancera R.L. Drug Discovery Today 13 (2008) 1090
3. Protopopova M., Bogatcheva E., Nikonenko B., Hundert S., Einck L., and Nacy C. Med. Chem. 3 (2007) 301
4. Lee R.E., Protopopova M., Crooks E., Slayden R.A., Terrot M., and Barry III C.E. J. Comb. Chem. 5 (2003) 172
5. Bogatcheva E., Hanrahan C., Nikonenko B., Samala R., Chen P., Gearhart G., Barbosa F., Einck L., Nacy C., and Protopopova M. J. Med. Chem 49 (2006) 3045
6. Shepherd R.G., Baughn C., Cantral M.L., Goodstein B., Thomas J.P., and Wilkinson R.G. Ann. N. Y. Acad. Sci. 135 (1966) 686
7. Protopopova M., Hanrahan C., Nikonenko B., Samala R., Chen P., Gearhart G., Einck L., and Nacy C. J. Antimicrob. Chemother. 56 (2005) 968
8. Jia L., Tomaszewski J.E., Noker P.E., Gorman G.S., Glaze E., and Protopopova M. J. Pharmaceut. Biomed. Anal. 37 (2005) 793
9. Jia L., Tomaszewski J.E., Hanrahan C., Coward L., Noker P., Gorman G., Nikonenko B., and Protopopova M. Br. J. Pharmacol. 144 (2005) 80
10. Jia L., Noker P.E., Coward L., Gorman G.S., Protopopova M., and Tomaszewski J.E. Br. J. Pharmacol. 147 (2006) 476
11. Nikonenko B., Protopopova M., Samala R., Einck L., and Nacy C. Antimicrob. Agents Chemother. 51 (2007) 1563