Development of 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters as selective inhibitors of mitochondrial malate dehydrogenase (mMDH)

European Journal of Medicinal Chemistry

Volumn 45, Issue 1, 2010, Pages 335-342

  Becker, Anja ^a   Kohfeld, Simone ^a   Lader, Annette ^a   Preu, Lutz ^a   Pies, Tanja ^b   Wieking, Karen ^b   Ferandin, Yoan ^c   Knockaert, Marie ^c   Meijer, Laurent ^c   Kunick, Conrad ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^b UNIVERSITY OF HAMBURG   (Germany)

^c STATION BIOLOGIQUE   (France)

Author keywords

Antiproliferative activity; Enzyme inhibition; Kinase; Mitochondrial malate dehydrogenase; Paullone

Indexed keywords

5 (3,4 DICHLOROBENZYL) 7,12 DIHYDROINDOLO[3,2 D][1]BENZAZEPIN 6(5H) ONE; 5 (4 METHYLBENZYL) 7,12 DIHYDROINDOLO[3,2 D][1]BENZAZEPIN 6(5H) ONE; 5 BENZYL 9 CHLORO 7,12 DIHYDROINDOLO[3,2 D][1]BENZAZEPIN 6(5H) ONE; 5 BENZYL 9 METHYL 7,12 DIHYDROINDOLO[3,2 D][1]BENZAZEPIN 6(5H) ONE; 5 BENZYL 9 TERT BUTYL 7,12 DIHYDROINDOLO[3,2 D][1]BENZAZEPIN 6(5H) ONE; 5 BENZYL 9 TRIFLUOROMETHYL 7,12 DIHYDROINDOLO[3,2 D][1]BENZAZEPIN 6(5H) ONE; 9 BROMO 5 (3,4 DICHLOROBENZYL) 7,12 DIHYDROINDOLO[3,2 D][1]BENZAZEPIN 6(5H) ONE; 9 BROMO 5 (4 METHOXYBENZYL) 7,12 DIHYDROINDOLO[3,2 D][1]BENZAZEPIN 6(5H) ONE; 9 BROMO 5 (4 METHYLBENZYL) 7,12 DIHYDROINDOLO[3,2 D][1]BENZAZEPIN 6(5H) ONE; 9 TERT BUTYL 5 (3,4 DICHLOROBENZYL) 7,12 DIHYDROINDOLO[3,2 D][1]BENZAZEPIN 6(5H) ONE; BUTYL 6 OXO 5,6,7,12 TETRAHYDROINDOLO[3,2 D][1]BENZAZEPINE 9 CARBOXYLATE; ENZYME INHIBITOR; ETHYL 6 OXO 5,6,7,12 TETRAHYDROINDOLO[3,2 D][1]BENZAZEPINE 9 CARBOXYLATE; HEXYL 6 OXO 5,6,7,12 TETRAHYDROINDOLO[3,2 D][1]BENZAZEPINE 9 CARBOXYLATE; MALATE DEHYDROGENASE; OCTYL 6 OXO 5,6,7,12 TETRAHYDROINDOLO[3,2 D][1]BENZAZEPINE 9 CARBOXYLATE; PENTYL 6 OXO 5,6,7,12 TETRAHYDROINDOLO[3,2 D][1]BENZAZEPINE 9 CARBOXYLATE; PROPYL 6 OXO 5,6,7,12 TETRAHYDROINDOLO[3,2 D][1]BENZAZEPINE 9 CARBOXYLATE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER INHIBITION; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL;

BENZAZEPINES; CARBOXYLIC ACIDS; CELL LINE, TUMOR; DRUG DISCOVERY; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MALATE DEHYDROGENASE; MITOCHONDRIA; SUBSTRATE SPECIFICITY;

EID: 72049097934     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.10.018     Document Type: Article

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