Synthesis and structure-activity relationship of novel lactam-fused chroman derivatives having dual affinity at the 5-HT1A receptor and the serotonin transporter

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 1, 2010, Pages 222-227

  Shen, Zhongqi ^a   Siva Ramamoorthy, P ^a   Hatzenbuhler, Nicole T ^a   Evrard, Deborah A ^a   Childers, Wayne ^a   Harrison, Boyd L ^a   Chlenov, Michael ^a   Hornby, Geoffrey ^a   Smith, Deborah L ^a   Sullivan, Kelly M ^a   Schechter, Lee E ^a   Andree, Terrance H ^a  

^a PFIZER INC   (United States)

Author keywords

5 HT1A antagonist; Antidepressant; Central nervous system; Lactam fused chroman amine derivatives; Selective serotonin reuptake inhibitors

Indexed keywords

CHROMAN DERIVATIVE; CYCLIC AMP; LACTAM DERIVATIVE; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN TRANSPORTER;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

CHROMANS; CYCLIC AMP; DRUG DESIGN; LACTAMS; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 72049096609     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.10.134     Document Type: Article

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