A tentative quantitative structure-toxicity relationship study of benzodiazepine drugs

Toxicology in Vitro

Volumn 24, Issue 1, 2010, Pages 184-200

  Funar Timofei, Simona ^a   Ionescu, Daniela ^b   Suzuki, Takahiro ^c  

^a ACADEMY OF ROMANIAN SCIENTISTS   (Romania)

^b VICTOR BABES UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^c TOYO UNIVERSITY   (Japan)

Author keywords

Artificial neural networks (ANNs); Benzodiazepine; Genetic algorithm; Multiple linear regression (MLR); Partial least squares (PLS); Quantitative structure toxicity relationships (QSTR); Support vector machines (SVMs)

Indexed keywords

BENZODIAZEPINE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; HYDROPHOBICITY; LD 50; MOLECULAR MECHANICS; MOLECULAR MODEL; PREDICTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; QUANTUM CHEMISTRY;

ALGORITHMS; ANIMALS; BENZODIAZEPINES; LEAST-SQUARES ANALYSIS; LETHAL DOSE 50; LINEAR MODELS; MICE; MODELS, MOLECULAR; NEURAL NETWORKS (COMPUTER); NONLINEAR DYNAMICS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 72049089038     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.09.009     Document Type: Article

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