Relationship of circulating cell-free DNA levels to cell-free fetal DNA levels, clinical characteristics and laboratory parameters in preeclampsia

BMC Medical Genetics

Volumn 10, Issue , 2009, Pages

  Lazar, Levente ^a   Rigó Jr, János ^a   Nagy, Bálint ^a   Balogh, Krisztián ^b   Makó, Veronika ^c   Cervenak, László ^d   Mézes, Miklós ^b   Prohászka, Zoltán ^c,d   Molvarec, Attila ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b SZENT ISTVÁN UNIVERSITY   (Hungary)

^c SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^d INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; DNA; FIBRONECTIN; MALONALDEHYDE; VON WILLEBRAND FACTOR;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY MASS; CELL ACTIVATION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ENDOTHELIUM INJURY; ENZYME ACTIVITY; FEMALE; FETUS; GESTATIONAL AGE; HUMAN; LABORATORY TEST; LIVER NECROSIS; MAJOR CLINICAL STUDY; OXIDATIVE STRESS; PREECLAMPSIA; PROTEIN BLOOD LEVEL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SMOKING; SYSTOLIC BLOOD PRESSURE; ADOLESCENT; BLOOD; CELL FREE SYSTEM; FETUS BLOOD; GENETICS; MALE; METABOLISM; POLYMERASE CHAIN REACTION; PREGNANCY; RETROSPECTIVE STUDY;

ADOLESCENT; ADULT; CELL-FREE SYSTEM; DNA; FEMALE; FETAL BLOOD; HUMANS; MALE; POLYMERASE CHAIN REACTION; PRE-ECLAMPSIA; PREGNANCY; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 71949097207     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-10-120     Document Type: Article

References (19)

1. Witlin AG, Sibai BM. Hypertension in pregnancy: current concepts of preeclampsia. Annu Rev Med 1997, 48:115-127. 10.1146/annurev.med.48.1.115, 9046950.
2. Dekker GA, Sibai BM. Etiology and pathogenesis of preeclampsia: current concepts. Am J Obstet Gynecol 1998, 179:1359-1375. 10.1016/S0002-9378(98)70160-7, 9822529.
3. Lim KH, Zhou Y, Janatpour M, McMaster M, Bass K, Chun SH. Human cytotrophoblast differentiation/invasion is abnormal in pre-eclampsia. Am J Pathol 1997, 151:1809-1818. 1858365, 9403732.
4. Redman CW, Sargent IL. The pathogenesis of pre-eclampsia. Gynecol Obstet Fertil 2001, 29:518-522. 10.1016/S1297-9589(01)00180-1, 11575148.
5. Rusterholz C, Hahn S, Holzgreve W. Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia. Semin Immunopathol 2007, 29:151-162. 10.1007/s00281-007-0071-6, 17621700.
6. Redman CW, Sacks GP, Sargent IL. Preeclampsia: an excessive maternal inflammatory Response to pregnancy. Am J Obstet Gynecol 1999, 180:499-506. 10.1016/S0002-9378(99)70239-5, 9988826.
7. Zhong XY, Laivuori H, Livingston JC, Ylikorkala O, Sibai BM, Holzgreve W, Hahn S. Elevation of both maternal and fetal extracellular circulating deoxyribonucleic acid concentrations in the plasma of pregnant women with preeclampsia. Am J Obstet Gynecol 2001, 3:414-419.
8. Holzgreve W, Hahn S. Novel molecular biological approaches for the diagnosis of preeclampsia. Clin Chem 1999, 45:451-452.
9. Korabecna M, Opatrna S, Wirth J, Rulcova K, Eiselt J, Sefrna F, Horinek A. Cell-free plasma DNA during peritoneal dialysis and hemodialysis and in patients with chronic kidney disease. Ann N Y Acad Sci 2008, 1137:296-301. 10.1196/annals.1448.014, 18837963.
10. Placer ZA, Cushman LL, Johnson BC. Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems. Anal Biochem 1966, 16:359-64. 10.1016/0003-2697(66)90167-9, 6007581.
11. Wataganara T, Bianchi DW. Fetal cell-free nucleic acids in the maternal circulation: new clinical applications. Ann N Y Acad Sci 2004, 1022:90-99. 10.1196/annals.1318.015, 15251945.
12. Gänshirt D, Smeets FW, Dohr A, Walde C, Stehen I, Lapucci C. Enrichment of fetal nucleated red blood cells from the maternal circulation for prenatal diagnosis: experiences with triple density gradient and MACS based on more than 600 cases. Fetal Diagn Ther 1998, 13:276-286. 10.1159/000020854, 9813420.
13. Swinkels DW, de Kok JB, Hendriks JC, Wiegerinck E, Zusterzeel PL, Steegers EA. Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome as a complication of preeclampsia in pregnant women increases the amount of cell-free fetal and maternal DNA in maternal plasma and serum. Clin Chem 2002, 48:650-653.
14. Holzgreve W, Ghezzi F, Di Naro E, Maymon E, Gänshirt D, Hahn S. Disturbed fetomaternal cell traffic in preeclampsia. Obstet Gynecol 1998, 91:669-672. 10.1016/S0029-7844(98)00068-4, 9572208.
15. Lo YM, Leung TN, Tein MS, Sargent IL, Zhang J, Lau TK. Quantitative abnormalities of fetal DNA in maternal serum in preeclampsia. Clin Chem 1999, 45:184-188.
16. Anker P, Mulcahy H, Chen XQ, Stroun M. Detection of circulating tumour DNA in the blood (plasma/serum) of cancer patients. Cancer Metastasis Rev 1999, 18:65-73. 10.1023/A:1006260319913, 10505546.
17. Bret L, Lule J, Alary C, Appolinaire-Pilipenko S, Pourrat JP, Fournie GJ. Quantitation of blood plasma DNA as an index of in vivo cytotoxicity. Toxicology 1990, 61:283-292. 10.1016/0300-483X(90)90178-J, 2330600.
18. Holdenrieder S, Stieber P, Forg T, Kuhl M, Schulz L, Busch M. Apoptosis in serum of patients with solid tumours. Anticancer Res 1999, 19:2721-2724.
19. DiFederico E, Genbacev O, Fisher SJ. Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall. Am J Pathol 1999, 155:293-301. 1866652, 10393861.