P38 MAP Kinase inhibition promotes primary tumour growth via VEGF independent mechanism

World Journal of Surgical Oncology

Volumn 7, Issue , 2009, Pages

  O'Sullivan, Adrian W ^a   Wang, Jiang H ^a   Redmond, Henry P ^a  

^a University College Cork and INFANT Centre   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; MITOGEN ACTIVATED PROTEIN KINASE P38; VASCULOTROPIN; 4-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)-5-(4-PYRIDYL)IMIDAZOLE; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE; VASCULOTROPIN A;

ADENOCARCINOMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BAGG ALBINO MOUSE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; TUMOR VOLUME; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; METABOLISM; MOUSE; PATHOLOGY; SURVIVAL RATE; TUMOR CELL CULTURE;

ADENOCARCINOMA; ANIMALS; APOPTOSIS; CELL PROLIFERATION; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; G1 PHASE; IMIDAZOLES; MICE; MICE, INBRED BALB C; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; SURVIVAL RATE; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 71849102351     PISSN: None     EISSN: 14777819     Source Type: Journal    
DOI: 10.1186/1477-7819-7-89     Document Type: Article

References (17)

1. Obata O, Brown G, Yaffe M. MAP kinase pathways activated by stress: The p38-MAPK pathway. Crit Care Med 2000, 28(4):N67-N77. 10807318, 10.1097/00003246-200004001-00008.
2. O'Sullivan AW, Wang JH, Redmond HP. The role of P38-MAPK and PKC in BLP induced TNF-alpha release, apoptosis, and NFkappaB activation in THP-1 monocyte cells. The Journal of surgical research 2009, 151(1):138-144. 18675993, 10.1016/j.jss.2008.02.031.
3. Kraatz J, Clair L, Rodriguez JL, West MA. Macrophage TNF secretion in endotoxin tolerence: Role of SAPK, p38, and MAPK. J Surg Res 1999, 83:158-164. 10329111, 10.1006/jsre.1999.5587.
4. Shames BD, Selzman CH, Pulido EJ, Meng X, Meldrum DR, McIntyre RC, Harken AH, Banerjee A. LPS-Induced NF-kB Activation and TNF-L Release in human monocytes are protein tyrosine kinase dependent and protein kinase C independent. J Surg Res 1999, 83:69-74. 10210645, 10.1006/jsre.1998.5564.
5. Sovak MA, Bellas RE, Kim DW, Zanieski GJ, Rogers AE, Traish AM, Sonenshein GE. Aberrant nuclear factor-B/Rel expression and the pathogenesis of breast cancer. J Clin Investig 1997, 100:2952-2960. 9399940, 10.1172/JCI119848, 508506.
6. Dong G, Chen Z, Kato T, Van Waes C. The host environment promotes the constitutive activation of nuclear factor-kappaB and proinflammatory cytokine expression during metastatic tumor progression of murine squamous cell carcinoma. Cancer Res 1999, 59(14):3495-3504.
7. Glarakis IS, Savva S, Spandidos DA. Activation of the ras genes in malignant and premalignant colorectal tumors. Oncology reports 1998, 5(6):1451-1454.
8. Mansour SJ, Matten WT, Hermann AS, Candia JM, Rong S, Fukasawa K, Woude GF, Ahn NG. Transformation of mammalian cells by constitutively active MAP kinase kinase. Science (New York, NY) 1994, 265(5174):966-970.
9. Greenberg AK, Basu S, Hu J, Yie TA, Tchou-Wong KM, Rom WN, Lee TC. Selective p38 activation in human non-small cell lung cancer. American journal of respiratory cell and molecular biology 2002, 26(5):558-564.
10. Hardwick JC, Brink GR, Offerhaus GJ, van Deventer SJ, Peppelenbosch MP. NF-kappaB, p38-MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps. Oncogene 2001, 20(7):819-827. 11314016, 10.1038/sj.onc.1204162.
11. Atten MJ, Attar BM, Holian O. Decreased MAP kinase activity in human gastric adenocarcinoma. Biochemical and biophysical research communications 1995, 212(3):1001-1006.
12. O'Sullivan AW, Wang JH, Redmond HP. NF-kappaB and P38-MAPK Inhibition Improve Survival in Endotoxin Shock and in a Cecal Ligation and Puncture Model of Sepsis in Combination With Antibiotic Therapy. The Journal of surgical research 2009, 151(1):138-44. 18675993, 10.1016/j.jss.2008.02.031.
13. Woods K, El-Naggar A, Clayman G, Grimm E. Variable expression of cytokines in human head and neck squamous cell carcinoma cell lines and consistent expression in surgical specimens. Cancer Res 1998, 58(14):3132-3141.
14. Chen Z, Colon I, Ortiz N, Callister M, Dong G, Pegram M, Arosarena O, Strome S, Nicholson J, Van Waes C. Effects of interleukin-1alpha, interleukin-1 receptor antagonist, and neutralizing antibody on proinflammatory cytokine expression by human squamous cell carcinoma lines. Cancer Res 1998, 58(16):3668-3676.
15. Scheibenbogen C, Mohler T, Haefele J, Hunstein W, Keilholz U. Serum interleukin-8 (IL-8) is elevated in patients with metastatic melanoma and correlates with tumour load. Melanoma Res 1995, 5(3):179-181. 7640519, 10.1097/00008390-199506000-00006.
16. Licato LL, Brenner DA. Analysis of signaling protein kinases in human colon or colorectal carcinomas. Digestive diseases and sciences 1998, 43(7):1454-1464.
17. Loda M, Capodieci P, Mishra R, Yao H, Corless C, Grigioni W, Wang Y, Magi-Galluzzi C, Stork PJ. Expression of mitogen-activated protein kinase phosphatase-1 in the early phases of human epithelial carcinogenesis. Am J Pathol 1996, 149(5):1553-1564. 1865259, 8909245.