Ghrelin receptor expression in lymphocytes isolated from adult cystic fibrosis patients

Respiration

Volumn 79, Issue 2, 2009, Pages 141-146

  Cohen, Rubin I ^a   Chandra, Subani ^a   Koenig, Seth ^a   Tsang, Donna ^a   Wilson, David ^a   McCloskey, Thomas ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Cystic fibrosis; Ghrelin; Ghrelin receptor; Weight loss

Indexed keywords

CYTOKINE; GHRELIN RECEPTOR; INTERLEUKIN 1; INTERLEUKIN 6; PEPTIDE HORMONE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; APPETITE; ARTICLE; BLOOD LEVEL; BODY COMPOSITION; BODY MASS; CACHEXIA; CELL ISOLATION; CLINICAL ARTICLE; CYSTIC FIBROSIS; DISEASE EXACERBATION; FEEDING BEHAVIOR; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; INFLAMMATION; LYMPHOCYTE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; WEIGHT REDUCTION;

ADULT; ANOREXIA; BODY MASS INDEX; CACHEXIA; CASE-CONTROL STUDIES; CYSTIC FIBROSIS; CYTOKINES; FEMALE; HUMANS; LYMPHOCYTES; MALE; MIDDLE AGED; RECEPTORS, GHRELIN;

EID: 71849100436     PISSN: 00257931     EISSN: None     Source Type: Journal    
DOI: 10.1159/000254486     Document Type: Article

References (16)

1. Dinwiddie R: Pathogenesis of lung disease in cystic fibrosis. Respiration 2000; 67: 3-8.
2. Ionescu AA, Nixon LS, Evans WD, Stone MD, Lewis-Jenkins V, Chatham K, Shale DJ: Bone density, body composition, and inflammatory status in cystic fibrosis. Am J Respir Crit Care Med 2000; 162: 789-794.
3. Meier U, Gressner AM: Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem 2004; 50: 1511-1525.
4. Inui A: Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nat Rev Neurosci 2001; 2: 551-560.
5. Cohen RI, Tsang D, Koenig S, Wilson D, Mc- Closkey T, Chandra S: Plasma ghrelin and leptin in adult cystic fibrosis patients. J Cyst Fibros 2008; 7: 398-402.
6. Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, Fairclough P, Bhattacharya S, Carpenter R, Grossman AB, Korbonits M: The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 2002; 87: 2988-2991.
7. Dixit VD, Schaffer EM, Pyle RS, Collins GD, Sakthivel SK, Palaniappan R, Lillard JW, Taub DD: Ghrelin inhibits leptin- and activation- induced proinflammatory cytokine expression by human monocytes and T cells. J Clin Invest 2004; 114: 57-66.
8. Li A, Cheng G, Zhu GH, Tarnawski AS: Ghrelin stimulates angiogenesis in human microvascular endothelial cells: implications beyond GH release. Biochem Biophys Res Commun 2007; 353: 238-243.
9. Li WG, Gavrila D, Liu X, Wang L, Gunnlaugsson S, Stoll LL, McCormick ML, Sigmund CD, Tang C, Weintraub NL: Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells. Circulation 2004; 109: 2221-2226.
10. Koch C, Hoiby N: Diagnosis and treatment of cystic fibrosis. Respiration 2000; 67: 239-247.
11. Goss CH, Burns JL: Exacerbations in cystic fibrosis. 1. Epidemiology and pathogenesis. Thorax 2007; 62: 360-367.
12. Knudson RJ, Lebowitz MD, Holberg CJ, Burrows B: Changes in the normal maximal expiratory flow-volume curve with growth and aging. Am Rev Respir Dis 1983; 127: 725-734.
13. Hollander FM, De Roos NM, De Vries JH, Van Berkhout FT: Assessment of nutritional status in adult patients with cystic fibrosis. Whole-body bioimpedance vs. body mass index, skin folds, and leg-to-leg bioimpedance. J Am Diet Assoc 2005; 105: 549-555.
14. Fleisher TA, Marti GE: Detection of unseparated human lymphocytes by flow cytometry. Curr Protoc Immunol 2001;chapter 7: unit 7.9.
15. McCloskey TW, Haridas V, Pahwa R, Pahwa S: Human immunodeficiency virus gag and pol-specific CD8 T cells in perinatal HIV infection. Cytometry 2001; 46: 265-270.
16. Pahwa R, McCloskey TW, Aroniadis OC, et al: CD8+ T cells in HIV disease exhibit cytokine receptor perturbation and poor TCR activation but are responsive to gammachain cytokine driven proliferation. J Infect Dis 2006; 193: 879-887.