Analgesic effects of butorphanol tartrate and phenylbutazone administered alone and in combination in young horses undergoing routine castration

Journal of the American Veterinary Medical Association

Volumn 235, Issue 10, 2009, Pages 1194-1203

  Sanz, Macarena G ^a,b   Sellon, Debra C ^a   Cary, Julie A ^a   Hines, Melissa T ^a   Farnsworth, Kelly D ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; BUTORPHANOL; PHENYLBUTAZONE;

ANIMAL; ANIMAL DISEASE; ARTICLE; DRUG COMBINATION; HORSE; MALE; METHODOLOGY; ORCHIECTOMY; POSTOPERATIVE PAIN; TIME;

ANALGESICS; ANIMALS; BUTORPHANOL; DRUG THERAPY, COMBINATION; HORSES; MALE; ORCHIECTOMY; PAIN, POSTOPERATIVE; PHENYLBUTAZONE; TIME FACTORS;

ANIMALIA; EQUIDAE;

EID: 71849100300     PISSN: 00031488     EISSN: None     Source Type: Journal    
DOI: 10.2460/javma.235.10.1194     Document Type: Article

References (51)

1. Mellor DJ, Stafford KJ. Acute castration and/or tailing distress and its alleviation in lambs. N Z Vet J 2000;48:33-43.
2. Molony V, Kent JE, McKendrick IJ. Validation of a method for assessment of an acute pain in lambs. Appl Anim Behav Sci 2002;76:215-238.
3. Kent JE, Jackson RE, Molony V, et al. Effects of acute pain reduction methods on the chronic inflammatory lesions and behaviour of lambs castrated and tail docked with rubber rings at less than two days of age. Vet J 2000;160:33-41.
4. McGlone JJ, Hellman JM. Local and general anesthetic effects on behavior and performance of two- and seven-week-old castrated and uncastrated piglets. J Anim Sci 1988;66:3049-3058.
5. Thornton PD, Waterman-Pearson AE. Quantification of the pain and distress responses to castration in young lambs. Res Vet Sci 1999;66:107-118.
6. Wood GN, Molony V, Fleetwood-Walker SM, et al. Effects of local anesthesia and intravenous naloxone on the changes in behaviour and plasma concentrations of Cortisol produced by castration and tail docking with tight rubber rings in young lambs. Res Vet Sci 1991;51:193-199.
7. Kent JE, Thrusfield MV, Molony V, et al. Randomised, controlled field trial of two new techniques for the castration and tail docking of lambs less than two days of age. Vet Rec 2004;154:193-200.
8. Molony V, Kent JE, Hosie BD, et al. Reduction in pain suffered by lambs at castration. Vet J 1997;153:205-213.
9. Stafford KJ, Mellor DJ, Todd SE, et al. Effects of local anaesthesia or local anaesthesia plus a non-steroidal anti-inflammatory drug on the acute Cortisol response of calves to five different methods of castration. Res Vet Sci 2002;73:61-70.
10. Haga HA, Ranheim B. Castration of piglets: the analgesic effects of intratesticular and intrafunicular lidocaine injection. Vet An-aesth Analg 2005;32:1-9.
11. Prugner W, Huber R, Luhmann R. Eltenac, A new anti-inflammatory and analgesic drug for horses: clinical aspects. J Vet Pharmacol Ther 1991;14:193-199.
12. Flecknell PA, Raptopoulous D, Gasthuys F, et al. Castration of horses and analgesia. Vet Rec 2001;149:159-160.
13. Haga HA, Dolvik NI. Electroencephalographic and cardiovascular variables as nociceptive indicators in isoflurane-anaesthe-tized horses. Vet Anaesth Analg 2005;32:128-135.
14. Haga HA, Lykkjen S, Revold T, et al. Effect of intratesticular injection of lidocaine on cardiovascular responses to castration in isoflurane- anesthetized stallions. Am J Vet Res 2006;67:403-408.
15. Capner C. Castration of horses and analgesia (lett). Vet Rec 2001;149:252.
16. Harris R. Castration of horses and analgesia (lett). Vet Rec 2001;149:279-280.
17. Jones R. Castration of horses and analgesia (lett). Vet Rec 2001;149:252.
18. Green P. Castration of horses and analgesia (lett). Vet Rec 2001;149:159-160.
19. Price J, Eager RA, Welsh EM, et al. Current practice relating to equine castration in the UK. Res Vet Sci 2005;78:277-280.
20. Price J, Marques JM, Welsh EM, et al. Pilot epidemiological study of attitudes towards pain in horses. Vet Rec 2002;151:570-575.
21. Molony V, Kent JE. Assessment of acute pain in farm animals using behavioral and physiological measurements. J Anim Sci 1997;75:266-272.
22. Price J, Catriona S, Welsh EM, et al. Preliminary evaluation of a behaviour-based system for assessment of post-operative pain in horses following arthroscopic surgery. Vet Anaesth Analg 2003;30:124-137.
23. Ashley FH, Waterman-Pearson AE, Whay HR. Behavioural assessment of pain in horses and donkeys: application to clinical practice and future studies. Equine Vet J 2005;37:565-575.
24. Mellor DJ, Murray L. Changes in the Cortisol responses of lambs to tail docking, castration and ACTH injection during the first seven days after birth. Res Vet Sci 1989;46:392-395.
25. Graham MJ, Kent JE, Molony V The influence of the site of application on the behavioural responses of lambs to tail docking by rubber ring. Vet J 2002;164:240-243.
26. Graham MJ, Kent JE, Molony V Effects of four analgesic treatments on the behavioural and Cortisol responses of 3-week-old lambs to tail docking. Vet J 1997;153:87-97.
27. Kent JE, Molony V, Robertson IS. Comparison of the Burdizzo and rubber ring methods for castrating and tail docking lambs. Vet Rec 1995;136:192-196.
28. Mama KR, Steffey EP, Pascoe PJ. Evaluation of propofol for general anesthesia in premedicated horses. Am J Vet Res 1996;57:512-516.
29. Young SS, Taylor PM. Factors influencing the outcome of equine anaesthesia: a review of 1314 cases. Equine Vet J 1993;25:147-151.
30. Schumacher J. The testis. In: Equine surgery. 3rd ed. Philadelphia: WB Saunders Co, 2005;788-793.
31. Sellon DC, Monroe VL, Roberts MC, et al. Pharmacokinetics and adverse effects of butorphanol administered by single intravenous injection or continuous intravenous infusion in horses. Am J Vet Res 2001;62:183-189.
32. Arguedas MG, Hines MT, Papich MG, et al. Pharmacokinetics of butorphanol and evaluation of physiologic and behavioral effects after intravenous and intramuscular administration to neonatal foals. J Vet Intern Med 2008;22:1417-1426.
33. Holland JL, Kronfeld DS, Meacham TN. Behavior of horses is affected by soy lecithin and com oil in the diet. J Anim Sci 1996;74:1252-1255.
34. Pritchett LC, Ulibarri C, Roberts MC, et al. Identification of potential physiological and behavioral indicators of postoperative pain in horses after exploratory celiotomy for colic. Appl Anim Behav Sci 2003;80:31-43.
35. Sellon DC, Roberts MC, Blikslager AT, et al. Effects of continu-ous rate intravenous infusion of butorphanol on physiologic and outcome variables in horses after celiotomy. J Vet Intern Med 2004;18:555-563.
36. Hewson CJ, Dohoo IR, Lemke KA, et al. Canadian veterinarians' use of analgesics in cattle, pigs, and horses in 2004 and 2005. Can Vet J 2007;48:155-164.
37. Corletto I; Raisis AA, Brearley JC. Comparison of morphine and butorphanol as pre-anaesthetic agents in combination with romifidine for field castration in ponies. Vet Anaesth Analg 2005 32:16-22.
38. Taylor PM, Kirby JJ, Shrimpton DJ, et al. Cardiovascular effects of surgical castration during anaesthesia maintained with halo-thane or infusion of detomidine, ketamine and guaifenesin in ponies. Equine Vet J 1998;30:304-309.
39. Murrell JC, Johnson CB, White KL, et al. Changes in the EEG during castration in horses and ponies anaesthetized with halo-thane. Vet Anaesth Analg 2003;30:138-146.
40. Joyce J, Hendrickson DA. Comparison of intraoperative pain responses following intratesticular or mesorchial injection of lidocaine in standing horses undergoing laparoscopic cryptor-chidectomy. J Am Vet Med Assoc 2006;229:1779-1783.
41. Holton LL, Scott EM, Nolan AM, et al. Relationship between physiological factors and clinical pain in dogs scored using a numerical rating scale. J Small Anim Pract 1998;39:469-474.
42. Raekallio M, Taylor PM, Bennett RC. Preliminary investigations of pain and analgesia assessment in horses administered phenylbutazone or placebo after arthroscopic surgery. Vet Surg 1997;26:150-155.
43. Rietmann TR, Stauffacher M, Bernasconi P, et al. The association between heart rate, heart rate variability, endocrine and behavioural pain measures in horses suffering from laminitis. J Vet Med A Physiol Pathol Clin Med 2004;51:218-225.
44. Bussieres G, Jacques C, Lainay O, et al. Development of a composite orthopaedic pain scale in horses. Res Vet Sci 2008;85:294-306.
45. Sojka JE, Adams SB, Lamar CH, et al. Effect of butorphanol, pentazocine, meperidine, or metoclopramide on intestinal motility in female ponies. Am J Vet Res 1988;49:527-529.
46. Little D, Redding WR, Blikslager AT. Risk factors for reduced postoperative fecal output in horses: 37 cases (1997-1998). J Am Vet Med Assoc 2001;218:414-420.
47. Singh S, McDonell WN, Young SS, et al. Cardiopulmonary and gastrointestinal motility effects of xylazine/ketamine-induced anesthesia in horses previously treated with glycopyrrolate. Am J Vet Res 1996;57:1762-1770.
48. Stafford KJ, Mellor DJ. The welfare significance of the castration of cattle: a review. NZVetJ 2005;53:271-278.
49. Dybdal NO, Hargreaves KM, Madigan JE, et al. Diagnostic testing for pituitary pars intermedia dysfunction in horses. J Am Vet Med Assoc 1994;204:627-632.
50. Taylor PM. Equine stress responses to anesthesia. Br J Anaesth 1989;63:702-709.
51. Fisher AD, Crowe MA, Alonso de la Varga ME, et al. Effect of castration method and the provision of local anesthesia on plasma Cortisol, scrotal circumference, growth, and feed intake of bull calves. J Anim Sci 1996;74:2336-2343.