Catalysis of fluorine addition to double bond: An improvement of method for synthesis of 18F PET agents

Applied Radiation and Isotopes

Volumn 68, Issue 2, 2010, Pages 293-296

  Kachur, Alexander V ^a,b   Dolbier Jr , William R ^c   Xu, Wei ^c   Koch, Cameron J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c University of Florida ^*  (United States)

Author keywords

18F labeling; Catalysis; EF5; Electrophylic fluorination

Indexed keywords

18F-LABELING; BORON TRIFLUORIDE; DOUBLE BONDS; EF5; EFFICIENT METHOD; PRODUCT YIELDS;

BORON; BORON COMPOUNDS; BROMINE; CATALYSIS; FLUORINATION; FLUORINE; HALOGENATION; INDUSTRIAL CHEMICALS; IODINE; LABELING;

POSITRON EMISSION TOMOGRAPHY;

2 (2 NITRO 1H IMIDAZOL 1 YL) N (2,2,3,3,3 PENTAFLUOROPROPYL)ACETAMIDE; BORON TRIFLUORIDE; BROMINE; FLUORINE 18; IODINE;

ARTICLE; CATALYSIS; CHEMICAL BOND; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SPECTROSCOPY;

CATALYSIS; FLUORINE; FLUORODEOXYGLUCOSE F18; ISOTOPE LABELING; RADIOPHARMACEUTICALS;

EID: 71849097681     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apradiso.2009.10.005     Document Type: Article

References (11)

1. Alam K., and Janzen A.F. Reactions of xenon difluoride. Part 6. Some reactions of phosphorus, arsenic and iodine compounds. Journal of Fluorine Chemistry 36 (1987) 179-184
2. 18F]-EF5, a marker for PET detection of hypoxia: synthesis of precursor and a new fluorination procedure. Applied Radiation and Isotopes 54 (2001) 73-80
3. 18F EF5 PET imaging with immunohistochemical validation in patients with brain lesions. International Journal of Radiation Oncology, Biology and Physics 66 (2006) S248
4. Komar G., Seppanen M., Eskola O., Lindholm P., Gronroos T.J., Forsback S., Sipila H., Evans S., Solin O., and Minn H. F-18-EF5: a new PET tracer for imaging hypoxia in head and neck cancer. Journal of Nuclear Medicine 49 (2008) 1944-1951
5. Rondestvedt Jr. C.S. Organic polyvalent iodine. Perfluoroalkyl iodide polyfluorides. I. Preparation and properties. Journal of the American Chemical Society 91 (1969) 3054-3061
6. Rozen S., and Brand M. A new method for introducing iodo and bromo fluorides into organic molecules using elemental fluorine. Journal of Organic Chemistry 50 (1985) 3342-3348
7. Rozen S., and Zamir D. Conversion of the carbonyl group the CF2 using IF. Journal of Organic Chemistry 56 (1991) 4695-4700
8. Ruf O., and Braida A. Bromine monofluoride. Zeitschrift für Anorganische und Allgemeine Chemie. 214 (1933) 81-90
9. Sartori P., and Lehnen A.J. Addition of iodine monofluoride to halogenated olefins. Chemische Berichte 104 (1971) 2813-2820
10. 18F-EF5. European Journal of Nuclear Medicine and Molecular Imaging 30 (2003) 259-266
11. Zupan M., and Pollak A. Stereochemistry of iodofluorination of phenyl-substituted olefins with (difluoroiodo)methane. Journal of the Chemical Society. Perkin Transactions 1 (1976) 745-748