Transcriptional effects of progesterone receptor antagonist in rat granulosa cells

Molecular and Cellular Endocrinology

Volumn 315, Issue 1-2, 2010, Pages 121-130

  Friberg, P Anders ^a   Larsson, D G Joakim ^a   Billig, Håkan ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Apoptosis; Mechanisms of hormone action; Ovary; Ovulation; Signal transduction

Indexed keywords

11BETA [4 (DIMETHYLAMINO)PHENYL] 4',5' DIHYDRO 6BETA METHYLSPIRO[ESTRA 4,9 DIENE 17BETA,2'(3'H) FURAN] 3 ONE; GONADOTROPIN; PROGESTERONE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENE EXPRESSION; GENE TARGETING; GRANULOSA CELL; IN VITRO STUDY; INCUBATION TIME; LUTEINIZATION; MICROARRAY ANALYSIS; NONHUMAN; OVULATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; TRANSCRIPTION REGULATION;

ANIMALS; APOPTOSIS; CELLS, CULTURED; ESTRENES; FEMALE; FURANS; GENE EXPRESSION PROFILING; GRANULOSA CELLS; HORMONE ANTAGONISTS; LUTEINIZATION; LUTEINIZING HORMONE; MICROARRAY ANALYSIS; OVULATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PROGESTERONE; TRANSCRIPTION, GENETIC;

EID: 71849085358     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2009.09.030     Document Type: Article

References (51)

1. Andersen C.L., Jensen J.L., and Orntoft T.F. Normalization of real-time quantitative reverse transcription-pcr data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res. 64 (2004) 5245-5250
2. Ashburner M., Ball C.A., Blake J.A., Botstein D., Butler H., Cherry J.M., Davis A.P., Dolinski K., Dwight S.S., Eppig J.T., Harris M.A., Hill D.P., Issel-Tarver L., Kasarskis A., Lewis S., Matese J.C., Richardson J.E., Ringwald M., Rubin G.M., and Sherlock G. Gene ontology: tool for the unification of biology. The gene ontology consortium. Nat. Genet. 25 (2000) 25-29
3. Boonyaratanakornkit V., Scott M.P., Ribon V., Sherman L., Anderson S.M., Maller J.L., Miller W.T., and Edwards D.P. Progesterone receptor contains a proline-rich motif that directly interacts with sh3 domains and activates c-src family tyrosine kinases. Mol. Cell 8 (2001) 269-280
4. Brosens J.J., and Gellersen B. Death or survival-progesterone-dependent cell fate decisions in the human endometrial stroma. J. Mol. Endocrinol. 36 (2006) 389-398
5. Calzado M.A., Renner F., Roscic A., and Schmitz M.L. Hipk2: a versatile switchboard regulating the transcription machinery and cell death. Cell Cycle 6 (2007) 139-143
6. Chaffin C.L., Hess D.L., and Stouffer R.L. Dynamics of periovulatory steroidogenesis in the rhesus monkey follicle after ovarian stimulation. Hum. Reprod. 14 (1999) 642-649
7. Chaffin C.L., Schwinof K.M., and Stouffer R.L. Gonadotropin and steroid control of granulosa cell proliferation during the periovulatory interval in rhesus monkeys. Biol. Reprod. 65 (2001) 755-762
8. Chaffin C.L., and Stouffer R.L. Local role of progesterone in the ovary during the periovulatory interval. Rev. Endocr. Metab. Disord. 3 (2002) 65-72
9. Cheon Y.P., Li Q., Xu X., DeMayo F.J., Bagchi I.C., and Bagchi M.K. A genomic approach to identify novel progesterone receptor regulated pathways in the uterus during implantation. Mol. Endocrinol. 16 (2002) 2853-2871
10. Cloke B., Huhtinen K., Fusi L., Kajihara T., Yliheikkila M., Ho K.K., Teklenburg G., Lavery S., Jones M.C., Trew G., Kim J.J., Lam E.W., Cartwright J.E., Poutanen M., and Brosens J.J. The androgen and progesterone receptors regulate distinct gene networks and cellular functions in decidualizing endometrium. Endocrinology 149 (2008) 4462-4474
11. de Winter J.P., ten Dijke P., de Vries C.J., van Achterberg T.A., Sugino H., de Waele P., Huylebroeck D., Verschueren K., and van den Eijnden-van Raaij A.J. Follistatins neutralize activin bioactivity by inhibition of activin binding to its type ii receptors. Mol. Cell. Endocrinol. 116 (1996) 105-114
12. Dennis Jr. G., Sherman B.T., Hosack D.A., Yang J., Gao W., Lane H.C., and Lempicki R.A. David: database for annotation, visualization, and integrated discovery. Genome Biol. 4 (2003) P3
13. Druse M.J., Gillespie R.A., Tajuddin N.F., and Rich M. S100b-mediated protection against the pro-apoptotic effects of ethanol on fetal rhombencephalic neurons. Brain Res. 1150 (2007) 46-54
14. Espey L.L., and Richards J.S. Temporal and spatial patterns of ovarian gene transcription following an ovulatory dose of gonadotropin in the rat. Biol. Reprod. 67 (2002) 1662-1670
15. Fahnenstich J., Nandy A., Milde-Langosch K., Schneider-Merck T., Walther N., and Gellersen B. Promyelocytic leukaemia zinc finger protein (plzf) is a glucocorticoid- and progesterone-induced transcription factor in human endometrial stromal cells and myometrial smooth muscle cells. Mol. Hum. Reprod. 9 (2003) 611-623
16. Fraser H.M., and Duncan W.C. Vascular morphogenesis in the primate ovary. Angiogenesis 8 (2005) 101-116
17. Friberg P.A., Larsson D.G., and Billig H. Dominant role of nuclear progesterone receptor in the control of rat periovulatory granulosa cell apoptosis. Biol. Reprod. 80 (2009) 1160-1167
18. Friberg P.A., Larsson D.G., Rung E., and Billig H. Apoptotic effects of a progesterone receptor antagonist on rat granulosa cells are not mediated via reduced protein isoprenylation. Mol. Reprod. Dev. 74 (2007) 1317-1326
19. Frijters R., Heupers B., van Beek P., Bouwhuis M., van Schaik R., de Vlieg J., Polman J., and Alkema W. Copub: a literature-based keyword enrichment tool for microarray data analysis. Nucleic Acids Res. 36 (2008) W406-410
20. Gougeon A. Dynamics of follicular growth in the human: a model from preliminary results. Hum. Reprod. 1 (1986) 81-87
21. Hughes Jr. F.M., and Gorospe W.C. Biochemical identification of apoptosis (programmed cell death) in granulosa cells: evidence for a potential mechanism underlying follicular atresia. Endocrinology 129 (1991) 2415-2422
22. Irving-Rodgers H.F., Catanzariti K.D., Aspden W.J., D'Occhio M.J., and Rodgers R.J. Remodeling of extracellular matrix at ovulation of the bovine ovarian follicle. Mol. Reprod. Dev. 73 (2006) 1292-1302
23. Iwai T., Nanbu Y., Iwai M., Taii S., Fujii S., and Mori T. Immunohistochemical localization of oestrogen receptors and progesterone receptors in the human ovary throughout the menstrual cycle. Virchows Arch. A: Pathol. Anat. Histopathol. 417 (1990) 369-375
24. Johnson A.L. Intracellular mechanisms regulating cell survival in ovarian follicles. Anim. Reprod. Sci. 78 (2003) 185-201
25. Kanamaru C., Yasuda H., and Fujita T. Involvement of smad proteins in tgf-beta and activin a-induced apoptosis and growth inhibition of liver cells. Hepatol. Res. 23 (2002) 211-219
26. Kang J.S., Alliston T., Delston R., and Derynck R. Repression of runx2 function by tgf-beta through recruitment of class ii histone deacetylases by smad3. EMBO J. 24 (2005) 2543-2555
27. Leonhardt S.A., Boonyaratanakornkit V., and Edwards D.P. Progesterone receptor transcription and non-transcription signaling mechanisms. Steroids 68 (2003) 761-770
28. Lin J., Yang Q., Yan Z., Markowitz J., Wilder P.T., Carrier F., and Weber D.J. Inhibiting s100b restores p53 levels in primary malignant melanoma cancer cells. J. Biol. Chem. 279 (2004) 34071-34077
29. Liu S., Li J., Tao Y., and Xiao X. Small heat shock protein alphab-crystallin binds to p53 to sequester its translocation to mitochondria during hydrogen peroxide-induced apoptosis. Biochem. Biophys. Res. Commun. 354 (2007) 109-114
30. Losel R.M., Besong D., Peluso J.J., and Wehling M. Progesterone receptor membrane component 1-many tasks for a versatile protein. Steroids 73 (2008) 929-934
31. Lydon J.P., DeMayo F.J., Conneely O.M., and O'Malley B.W. Reproductive phenotypes of the progesterone receptor null mutant mouse. J. Steroid Biochem. Mol. Biol. 56 (1996) 67-77
32. Lydon J.P., DeMayo F.J., Funk C.R., Mani S.K., Hughes A.R., Montgomery Jr. C.A., Shyamala G., Conneely O.M., and O'Malley B.W. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev. 9 (1995) 2266-2278
33. Natraj U., and Richards J.S. Hormonal regulation, localization, and functional activity of the progesterone receptor in granulosa cells of rat preovulatory follicles. Endocrinology 133 (1993) 761-769
34. Park O.K., and Mayo K.E. Transient expression of progesterone receptor messenger rna in ovarian granulosa cells after the preovulatory luteinizing hormone surge. Mol. Endocrinol. 5 (1991) 967-978
35. Porter D.A., Harman R.M., Cowan R.G., and Quirk S.M. Susceptibility of ovarian granulosa cells to apoptosis differs in cells isolated before or after the preovulatory lh surge. Mol. Cell. Endocrinol. 176 (2001) 13-20
36. Richer J.K., Jacobsen B.M., Manning N.G., Abel M.G., Wolf D.M., and Horwitz K.B. Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells. J. Biol. Chem. 277 (2002) 5209-5218
37. Robker R.L., and Richards J.S. Hormonal control of the cell cycle in ovarian cells: proliferation versus differentiation. Biol. Reprod. 59 (1998) 476-482
38. Rung E., Friberg P.A., Shao R., Larsson D.G.J., Nielsen E., Svensson P.A., Carlsson B., Carlsson L.M., and Billig H. Progesterone-receptor antagonists and statins decrease de novo cholesterol synthesis and increase apoptosis in rat and human periovulatory granulosa cells in vitro. Biol. Reprod. 72 (2005) 538-545
39. Shao R., Markström E., Friberg P.A., Johansson M., and Billig H. Expression of progesterone receptor (pr) a and b isoforms in mouse granulosa cells: stage-dependent pr-mediated regulation of apoptosis and cell proliferation. Biol. Reprod. 68 (2003) 914-921
40. Subramaniam M., Hawse J.R., Johnsen S.A., and Spelsberg T.C. Role of tieg1 in biological processes and disease states. J. Cell Biochem. 102 (2007) 539-548
41. Svensson E.C., Markström E., Andersson M., and Billig H. Progesterone receptor-mediated inhibition of apoptosis in granulosa cells isolated from rats treated with human chorionic gonadotropin. Biol. Reprod. 63 (2000) 1457-1464
42. Svensson E.C., Markström E., Shao R., Andersson M., and Billig H. Progesterone receptor antagonists org 31710 and ru 486 increase apoptosis in human periovulatory granulosa cells. Fertil. Steril. 76 (2001) 1225-1231
43. Tilly J.L., Billig H., Kowalski K.I., and Hsueh A.J. Epidermal growth factor and basic fibroblast growth factor suppress the spontaneous onset of apoptosis in cultured rat ovarian granulosa cells and follicles by a tyrosine kinase-dependent mechanism. Mol. Endocrinol. 6 (1992) 1942-1950
44. Tilly J.L., Kowalski K.I., Johnson A.L., and Hsueh A.J. Involvement of apoptosis in ovarian follicular atresia and postovulatory regression. Endocrinology 129 (1991) 2799-2801
45. Tung L., Mohamed M.K., Hoeffler J.P., Takimoto G.S., and Horwitz K.B. Antagonist-occupied human progesterone b-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by a-receptors. Mol. Endocrinol. 7 (1993) 1256-1265
46. Tusher V.G., Tibshirani R., and Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 5116-5121
47. Wotton D., and Massague J. Smad transcriptional corepressors in tgf beta family signaling. Curr. Top. Microbiol. Immunol. 254 (2001) 145-164
48. Zhang X.L., Zhang D., Michel F.J., Blum J.L., Simmen F.A., and Simmen R.C. Selective interactions of kruppel-like factor 9/basic transcription element-binding protein with progesterone receptor isoforms a and b determine transcriptional activity of progesterone-responsive genes in endometrial epithelial cells. J. Biol. Chem. 278 (2003) 21474-21482
49. Zheng X., Boerboom D., and Carriere P. Transforming growth factor-{beta}1 inhibits luteinization and promotes apoptosis in bovine granulosa cells. Reproduction (2009)
50. Zhu Y., Bond J., and Thomas P. Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 2237-2242
51. Zhu Y., Rice C.D., Pang Y., Pace M., and Thomas P. Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 2231-2236