Heteromeric glycolipid complexes as modulators of autoantibody and lectin binding

Progress in Lipid Research

Volumn 49, Issue 1, 2010, Pages 87-95

  Rinaldi, S ^a   Brennan, K M ^a   Willison, H J ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Autoantibodies; Ganglioside; Glycolipid complexes; Immunoassay; Neuropathy; Siglec; Tetanus toxin

Indexed keywords

AUTOANTIBODY; BACTERIAL TOXIN; CARBOHYDRATE; EPITOPE; GANGLIOSIDE; GANGLIOSIDE GM1 ANTIBODY; GANGLIOSIDE GM2; GANGLIOSIDE GM3; GLYCOLIPID;

ANTIBODY DETECTION; ANTIGEN BINDING; AUTOIMMUNE DISEASE; BIOPHYSICS; CELL MEMBRANE; CELL MOTILITY; COMPLEX FORMATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GUILLAIN BARRE SYNDROME; HUMAN; IN VIVO STUDY; LECTIN BINDING; NONHUMAN; PERIPHERAL NEUROPATHY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REVIEW;

AUTOANTIBODIES; BINDING SITES; GANGLIOSIDES; GLYCOLIPIDS; LECTINS; PROTEIN BINDING;

BACTERIA (MICROORGANISMS);

EID: 71749115760     PISSN: 01637827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.plipres.2009.09.001     Document Type: Review

References (86)

1. Greenshields K.N., Halstead S.K., Zitman F.M., et al. The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice. J Clin Invest 119 (2009) 595-610
2. Kaida K., Morita D., Kanzaki M., et al. Ganglioside complexes as new target antigens in Guillain-Barre syndrome. Ann Neurol 56 (2004) 567-571
3. Regina Todeschini A., and Hakomori S.I. Functional role of glycosphingolipids and gangliosides in control of cell adhesion, motility, and growth, through glycosynaptic microdomains. Biochim Biophys Acta 1780 (2008) 421-433
4. Regina Todeschini A., Dos Santos J.N., Handa K., and Hakomori S.I. Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway. Proc Natl Acad Sci USA 105 (2008) 1925-1930
5. Willison H.J. Ganglioside complexes as targets for antibodies in Miller Fisher syndrome. J Neurol Neurosurg Psychiatry 77 (2006) 1002-1003
6. Willison H.J. Ganglioside complexes: new autoantibody targets in Guillain-Barre syndromes. Natl Clin Pract Neurol 1 (2005) 2-3
7. Kusunoki S., Kaida K., and Ueda M. Antibodies against gangliosides and ganglioside complexes in Guillain-Barre syndrome: new aspects of research. Biochim Biophys Acta 1780 (2008) 441-444
8. Rinaldi S., Brennan K.M., Goodyear C.S., et al. Analysis of lectin binding to glycolipid complexes using combinatorial glycoarrays. Glycobiology 19 (2009) 789-796
9. Schwarz A., and Futerman A.H. The localization of gangliosides in neurons of the central nervous system: the use of anti-ganglioside antibodies. Biochim Biophys Acta 1286 (1996) 247-267
10. Lloyd K.O., Gordon C.M., Thampoe I.J., and DiBenedetto C. Cell surface accessibility of individual gangliosides in malignant melanoma cells to antibodies is influenced by the total ganglioside composition of the cells. Cancer Res 52 (1992) 4948-4953
11. Varki A. Selectin ligands. Proc Natl Acad Sci USA 91 (1994) 7390-7397
12. Simons K., and Ikonen E. Functional rafts in cell membranes. Nature 387 (1997) 569-572
13. Simons K., and Toomre D. Lipid rafts and signal transduction. Natl Rev Mol Cell Biol 1 (2000) 31-39
14. Svennerholm L., Bostrom K., Fredman P., et al. Gangliosides and allied glycosphingolipids in human peripheral nerve and spinal cord. Biochim Biophys Acta 1214 (1994) 115-123
15. Fishman P.H. Normal and abnormal biosynthesis of gangliosides. Chem Phys Lipids 13 (1974) 305-326
16. Fishman P.H., and Brady R.O. Biosynthesis and function of gangliosides. Science 194 (1976) 906-915
17. Dicesare J.L., and Dain J.A. The enzymic synthesis of ganglioside. IV. UDP-N-acetylgalactosamine: (N-acetylneuraminyl)-galactosylglucosyl ceramide N-acetylgalactosaminyltransferase in rat brain. Biochim Biophys Acta 231 (1971) 385-393
18. van Genderen I.L., van Meer G., Slot J.W., et al. Subcellular localization of Forssman glycolipid in epithelial MDCK cells by immuno-electronmicroscopy after freeze-substitution. J Cell Biol 115 (1991) 1009-1019
19. Matyas G.R., and Morre D.J. Subcellular distribution and biosynthesis of rat liver gangliosides. Biochim Biophys Acta 921 (1987) 599-614
20. Muthing J., Maurer U., Neumann U., et al. Glycosphingolipids of skeletal muscle: I. Subcellular distribution of neutral glycosphingolipids and gangliosides in rabbit skeletal muscle. Carbohydr Res 307 (1998) 135-145
21. Robertis E., De Lapetina E.G., and Fiszer S. Subcellular distribution and possible role of gangliosides in the CNS. Adv Exp Med Biol 71 (1976) 105-121
22. Sonnino S., Mauri L., Chigorno V., and Prinetti A. Gangliosides as components of lipid membrane domains. Glycobiology 17 (2007) 1R-13R
23. Michel C., and Echten-Deckert G. Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum. FEBS Lett 416 (1997) 153-155
24. Kolter T., Proia R.L., and Sandhoff K. Combinatorial ganglioside biosynthesis. J Biol Chem 277 (2002) 25859-25862
25. Burger K.N., van der B.P., and van Meer G G. Topology of sphingolipid galactosyltransferases in ER and Golgi: transbilayer movement of monohexosyl sphingolipids is required for higher glycosphingolipid biosynthesis. J Cell Biol 133 (1996) 15-28
26. Keenan T.W., Morre D.J., and Basu S. Ganglioside biosynthesis. Concentration of glycosphingolipid glycosyltransferases in Golgi apparatus from rat liver. J Biol Chem 249 (1974) 310-315
27. van Echten G., and Sandhoff K. Ganglioside metabolism. Enzymology, topology, and regulation. J Biol Chem 268 (1993) 5341-5344
28. Hakomori S.I. Inaugural article: the glycosynapse. Proc Natl Acad Sci USA 99 (2002) 225-232
29. Karlsson K.A. Pathogen-host protein-carbohydrate interactions as the basis of important infections. Adv Exp Med Biol 491 (2001) 431-443
30. Schiavo G., and van der Goot F.G. The bacterial toxin toolkit. Natl Rev Mol Cell Biol 2 (2001) 530-537
31. Lalli G., Bohnert S., Deinhardt K., et al. The journey of tetanus and botulinum neurotoxins in neurons. Trends Microbiol 11 (2003) 431-437
32. Miller-Podraza H., Johansson P., Angstrom J., et al. Studies on gangliosides with affinity for Helicobacter pylori: binding to natural and chemically modified structures. Glycobiology 14 (2004) 205-217
33. Avril T., Wagner E.R., Willison H.J., and Crocker P.R. Sialic acid-binding immunoglobulin-like lectin 7 mediates selective recognition of sialylated glycans expressed on Campylobacter jejuni lipooligosaccharides. Infect Immun 74 (2006) 4133-4141
34. Crocker P.R., and Redelinghuys P. Siglecs as positive and negative regulators of the immune system. Biochem Soc Trans 36 (2008) 1467-1471
35. Tillack T.W., Allietta M., Moran R.E., and Young Jr. W.W. Localization of globoside and Forssman glycolipids on erythrocyte membranes. Biochim Biophys Acta 733 (1983) 15-24
36. Fujita A., Cheng J., Hirakawa M., et al. Gangliosides GM1 and GM3 in the living cell membrane form clusters susceptible to cholesterol depletion and chilling. Mol Biol Cell 18 (2007) 2112-2122
37. Fujita A, Cheng J, Fujimoto T. Segregation of GM1 and GM3 clusters in the cell membrane depends on the intact actin cytoskeleton. Biochim Biophys Acta 2009.
38. Janich P., and Corbeil D. GM1 and GM3 gangliosides highlight distinct lipid microdomains within the apical domain of epithelial cells. FEBS Lett 581 (2007) 1783-1787
39. Chen Y., Qin J., and Chen Z.W. Fluorescence-topographic NSOM directly visualizes peak-valley polarities of GM1/GM3 rafts in cell membrane fluctuations. J Lipid Res 49 (2008) 2268-2275
40. Eggens I., Fenderson B.A., Toyokuni T., and Hakomori S. A role of carbohydrate-carbohydrate interaction in the process of specific cell recognition during embryogenesis and organogenesis: a preliminary note. Biochem Biophys Res Commun 158 (1989) 913-920
41. Fenderson B.A., Zehavi U., and Hakomori S. A multivalent lacto-N-fucopentaose III-lysyllysine conjugate decompacts preimplantation mouse embryos, while the free oligosaccharide is ineffective. J Exp Med 160 (1984) 1591-1596
42. Crocker P.R., Paulson J.C., and Varki A. Siglecs and their roles in the immune system. Nat Rev Immunol 7 (2007) 255-266
43. Freeman S.D., Kelm S., Barber E.K., and Crocker P.R. Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules. Blood 85 (1995) 2005-2012
44. Hanasaki K., Varki A., and Powell L.D. CD22-mediated cell adhesion to cytokine-activated human endothelial cells. Positive and negative regulation by alpha 2-6-sialylation of cellular glycoproteins. J Biol Chem 270 (1995) 7533-7542
45. Ilyas A.A., Willison H.J., Quarles R.H., et al. Serum antibodies to gangliosides in Guillain-Barre syndrome. Ann Neurol 23 (1988) 440-447
46. Yuki N., Yoshino H., Sato S., and Miyatake T. Acute axonal polyneuropathy associated with anti-Gm1 antibodies following Campylobacter enteritis. Neurology 40 (1990) 1900-1902
47. Walsh F.S., Cronin M., Koblar S., et al. Association between glycoconjugate antibodies and campylobacter infection in patients with Guillain-Barre syndrome. J Neuroimmunol 34 (1991) 43-51
48. Kusunoki S., Iwamori M., Chiba A., et al. GM1b is a new member of antigen for serum antibody in Guillain-Barre syndrome. Neurology 47 (1996) 237-242
49. Yuki N., Tagawa Y., Irie F., et al. Close association of Guillain-Barre syndrome with antibodies to minor monosialogangliosides GM1b and GM1 alpha. J Neuroimmunol 74 (1997) 30-34
50. Yuki N., Yamada M., Sato S., et al. Association of Igg Anti-Gd1A antibody with severe Guillain-Barre-syndrome. Muscle Nerve 16 (1993) 642-647
51. Kusunoki S., Chiba A., Kon K., et al. N-Acetylgalactosaminyl GD1a is a target molecule for serum antibody in Guillain-Barre syndrome. Ann Neurol 35 (1994) 570-576
52. Willison H.J., Almemar A., Veitch J., and Thrush D. Acute ataxic neuropathy with cross-reactive antibodies to Gd(1B) and Gd(3) gangliosides. Neurology 44 (1994) 2395-2397
53. Mizoguchi K., Hase A., Obi T., et al. Two Species of antiganglioside antibodies in a patient with a pharyngeal-cervical-brachial variant of Guillain-Barre-syndrome. J Neurol Neurosurg Psychiatry 57 (1994) 1121-1123
54. Koga M., Yuki N., Ariga T., et al. Is IgG anti-GT1a antibody associated with pharyngeal-cervical-brachial weakness or oropharyngeal palsy in Guillain-Barre syndrome?. J Neuroimmunol 86 (1998) 74-79
55. O'Leary C.P., Veitch J., Durward W.F., et al. Acute oropharyngeal palsy is associated with antibodies to GQ1b and GT1a gangliosides. J Neurol Neurosurg Psychiatry 61 (1996) 649-651
56. Willison H.J., O'Leary C.P., Veitch J., et al. The clinical and laboratory features of chronic sensory ataxic neuropathy with anti-disialosyl IgM antibodies. Brain 124 (2001) 1968-1977
57. Yuki N., Sato S., Tsuji S., et al. Frequent presence of Anti-Gq1B antibody in Fishers syndrome. Neurology 43 (1993) 414-417
58. Chiba A., Kusunoki S., Shimizu T., and Kanazawa I. Serum IgG antibody to ganglioside GQ1b is a possible marker of Miller Fisher syndrome. Ann Neurol 31 (1992) 677-679
59. Inuzuka T., Miyatani N., Baba H., et al. IgM binding to sialosyllactosaminylparagloboside in a patient with polyradiculoneuropathy due to Mycoplasma pneumoniae infection. Acta Neurol Scand 78 (1988) 53-57
60. Hao Q., Saida T., Kuroki S., et al. Antibodies to gangliosides and galactocerebroside in patients with Guillain-Barre syndrome with preceding Campylobacter jejuni and other identified infections. J Neuroimmunol 81 (1998) 116-126
61. Kusunoki S., Chiba A., Hitoshi S., et al. Anti-Gal-C antibody in autoimmune neuropathies subsequent to mycoplasma-infection. Muscle Nerve 18 (1995) 409-413
62. Yuki N., Tagawa Y., and Handa S. Autoantibodies to peripheral nerve glycosphingolipids SPG, SLPG, and SGPG in Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy. J Neuroimmunol 70 (1996) 1-6
63. Tagawa Y., Handa S., and Yuki N. Anti-SGPG antibody in chronic inflammatory demyelinating polyneuropathy: nosological position of polyneuropathy associated with IgM anti-MAG/SGPG antibody. Ann Neurol 40 (1996) M113
64. Willison H.J., and Yuki N. Peripheral neuropathies and anti-glycolipid antibodies. Brain 125 (2002) 2591-2625
65. Rinaldi S., and Willison H.J. Ganglioside antibodies and neuropathies. Curr Opin Neurol 21 (2008) 540-546
66. Willison H.J., Veitch J., Swan A.V., et al. Inter-laboratory validation of an ELISA for the determination of serum anti-ganglioside antibodies. Eur J Neurol 6 (1999) 71-77
67. Kaida K., Morita D., Kanzaki M., et al. Anti-ganglioside complex antibodies associated with severe disability in GBS. J Neuroimmunol 182 (2007) 212-218
68. Kaida K., Kanzaki M., Morita D., et al. Anti-ganglioside complex antibodies in Miller Fisher syndrome. J Neurol Neurosurg Psychiatry 77 (2006) 1043-1046
69. Kaida K., Kamakura K., Ogawa G., et al. GD1b-specific antibody induces ataxia in Guillain-Barre syndrome. Neurology 71 (2008) 196-201
70. Kusunoki S., Mashiko H., Mochizuki N., et al. Binding of antibodies against GM1 and GD1b in human peripheral nerve. Muscle Nerve 20 (1997) 840-845
71. Boffey J., Nicholl D., Wagner E.R., et al. Innate murine B cells produce anti-disialosyl antibodies reactive with Campylobacter jejuni LPS and gangliosides that are polyreactive and encoded by a restricted set of unmutated V genes. J Neuroimmunol 152 (2004) 98-111
72. Boffey J., Odaka M., Nicoll D., et al. Characterisation of the immunoglobulin variable region gene usage encoding the murine anti-ganglioside antibody repertoire. J Neuroimmunol 165 (2005) 92-103
73. Bowes T., Wagner E.R., Boffey J., et al. Tolerance to self gangliosides is the major factor restricting the antibody response to lipopolysaccharide core oligosaccharides in Campylobacter jejuni strains associated with Guillain-Barre syndrome. Infect Immun 70 (2002) 5008-5018
74. Goodyear C.S., O'Hanlon G.M., Plomp J.J., et al. Monoclonal antibodies raised against Guillain-Barre syndrome-associated Campylobacter jejuni lipopolysaccharides react with neuronal gangliosides and paralyze muscle-nerve preparations. J Clin Invest 104 (1999) 697-708
75. Townson K., Boffey J., Nicholl D., et al. Solid phase immunoadsorption for therapeutic and analytical studies on neuropathy-associated anti-GM1 antibodies. Glycobiology 17 (2007) 294-303
76. Vimr E.R. Microbial sialidases: does bigger always mean better?. Trends Microbiol 2 (1994) 271-277
77. Da Silva J.S., Hasegawa T., Miyagi T., et al. Asymmetric membrane ganglioside sialidase activity specifies axonal fate. Nat Neurosci 8 (2005) 606-615
78. Yang L.J., Lorenzini I., Vajn K., et al. Sialidase enhances spinal axon outgrowth in vivo. Proc Natl Acad Sci USA 103 (2006) 11057-11062
79. Yuki N. Campylobacter sialyltransferase gene polymorphism directs clinical features of Guillain-Barre syndrome. [Review] [55 refs]. J Neurochem 2007;103 (1):150-8.
80. Godschalk P.C., van Belkum A., Van den B.N., et al. PCR-restriction fragment length polymorphism analysis of Campylobacter jejuni genes involved in lipooligosaccharide biosynthesis identifies putative molecular markers for Guillain-Barre syndrome. J. Clin. Microbiol. 45 7 (2007) 2316-2320
81. Aspinall G.O., McDonald A.G., Pang H., et al. Lipopolysaccharides of Campylobacter jejuni serotype O:19: structures of core oligosaccharide regions from the serostrain and two bacterial isolates from patients with the Guillain-Barre syndrome. Biochemistry 33 (1994) 241-249
82. Godschalk P.C., Kuijf M.L., Li J., et al. Structural characterization of Campylobacter jejuni lipooligosaccharide outer cores associated with Guillain-Barre and Miller Fisher syndromes. Infection Immunity 75 3 (2007) 1245-1254
83. Kuijf M.L., Godschalk P.C., Gilbert M., et al. Origin of ganglioside complex antibodies in Guillain-Barre syndrome. J Neuroimmunol 188 (2007) 69-73
84. Deinhardt K., Berninghausen O., Willison H.J., et al. Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1. J Cell Biol 174 (2006) 459-471
85. Goodfellow J.A., Bowes T., Sheikh K., et al. Overexpression of GD1a ganglioside sensitizes motor nerve terminals to anti-GD1a antibody-mediated injury in a model of acute motor axonal neuropathy. J Neurosci 25 (2005) 1620-1628
86. Avril T., North S.J., Haslam S.M., et al. Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2, 8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2, 8-sialyltransferase gene expression. J Leukoc Biol 80 (2006) 787-796