Synthesis and evaluation of (S,S)-N,N′-bis-[3-(2,2′,6,6′-tetramethylbenzhydryloxy)-2-hydroxy-propyl]-ethylenediamine (S2824) analogs with anti-tuberculosis activity

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 21, 2009, Pages 6074-6077

  Zhang, Xuelian ^a   Hu, Yanwei ^a,b   Chen, Shudan ^a   Luo, Rusong ^a   Yue, Jun ^c   Zhang, Ying ^d   Duan, Wenhu ^e   Wang, Honghai ^a  

^a FUDAN UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

^c SHANGHAI PULMONARY HOSPITAL   (China)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^e SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Antitubercular drug; MIC; Resistance

Indexed keywords

ETHAMBUTOL; ETHYLENEDIAMINE DERIVATIVE; ISONIAZID; N,N' BIS [3 (4,4' DIMEBROMOBENZHYDRYLOXY) 2 HYDROXY PROPYL] ETHYLENEDIAMINE; N,N' BIS [3 (4,4' DIMETHOXYBENZHYDRYLOXY) 2 HYDROXY PROPYL] ETHYLENEDIAMINE; N,N' BIS [3 (4,4' DIMETHYLBENZHYDRYLOXY) 2 HYDROXY PROPYL] ETHYLENEDIAMINE; RIFAMPICIN; STREPTOMYCIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIOSTASIS; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN;

ANTITUBERCULAR AGENTS; AZEPINES; BENZHYDRYL COMPOUNDS; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, BACTERIAL; ETHYLENEDIAMINES; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS;

MYCOBACTERIUM TUBERCULOSIS;

EID: 71749112435     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.09.035     Document Type: Article

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