Assessment of the role of histopathology and DNA image analysis in the diagnosis of molar and non-molar abortion: A study of 89 cases in the center of Tunisia

Pathology Research and Practice

Volumn 205, Issue 11, 2009, Pages 789-796

  Landolsi, Hanène ^a   Missaoui, Nabiha ^a   Yacoubi, Mohamed Tahar ^a   Trabelsi, Amel ^a   Rammeh Rommani, Soumaya ^a   Hidar, Samir ^b   Gribaa, Moez ^b   Hmissa, Sihem ^a   Mokni, Moncef ^a  

^a UNIVERSITY OF SOUSSE   (Tunisia)

^b FARHAT HACHED HOSPITAL   (Tunisia)

Author keywords

Histopathology; Hydatidiform mole; Image cytometry; Ploidy

Indexed keywords

DNA;

ABORTION; ADULT; ANEUPLOIDY; ARTICLE; CONSENSUS DEVELOPMENT; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; DIPLOIDY; DISEASE CLASSIFICATION; DNA CONTENT; FEMALE; FIRST TRIMESTER PREGNANCY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYDATIDIFORM MOLE; HYDROPIC ABORTION; IMAGE ANALYSIS; IMAGE CYTOMETRY; MAJOR CLINICAL STUDY; PATHOLOGIST; RETROSPECTIVE STUDY; TRIPLOIDY; TUNISIA;

ABORTION, SPONTANEOUS; ADULT; CHI-SQUARE DISTRIBUTION; DIAGNOSIS, DIFFERENTIAL; DNA; FEMALE; HUMANS; HYDATIDIFORM MOLE; MIDDLE AGED; PREGNANCY; PREGNANCY TRIMESTER, FIRST; STAINING AND LABELING;

EID: 71749103238     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2009.05.013     Document Type: Article

References (61)

1. Barclay I.D., Dabbagh L., Babiak J., et al. DNA analysis (ploidy) of molar pregnancies with image analysis on paraffin tissue sections. Am. J. Clin. Pathol. 100 (1993) 451-455
2. Berezowsky J., Zbieranowski I., Demers J., et al. DNA ploidy of hydatidiform moles and nonmolar conceptuses: a study using flow and tissue section image cytometry. Mod. Pathol. 8 (1995) 775-781
3. Bifulco C., Johnson C., Hao L., et al. Genotypic analysis of hydatidiform mole: an accurate and practical method of diagnosis. Am. J. Surg. Pathol. 32 (2008) 445-451
4. Cheville J.C., Greiner T., Robinson R.A., et al. Ploidy analysis by flow cytometry and fluorescence in situ hybridization in hydropic placentas and gestational trophoblastic disease. Hum. Pathol. 26 (1995) 753-757
5. Chew S.H., Perlman E.J., Williams R., et al. Morphology and DNA content analysis in the evaluation of first trimester placentas for partial hydatidiform mole (PHM). Hum. Pathol. 31 (2000) 914-924
6. Conran R.M., Hitchcock C.L., Popek E.J., et al. Diagnostic considerations in molar gestations. Hum. Pathol. 24 (1993) 41-48
7. Coukos G., Makrigiannakis A., Chung J., et al. Complete hydatidiform mole. A disease with a changing profile. J. Reprod. Med. 44 (1999) 698-704
8. Crisp H., Burton J.L., Stewart R., et al. Refining the diagnosis of hydatidiform mole: image ploidy analysis and p57KIP2 immunohistochemistry. Histopathology 43 (2003) 363-373
9. Davis J.R., Kerrigan D.P., Way D.L., et al. Partial hydatidiform moles: desoxyribonucleic acid content and course. Am. J. Obstet. Gynecol. 157 (1987) 969-973
10. Fukunaga M., Endo Y., and Ushigome S. Flow cytometric and clinicopathologic study of 197 hydatidiform moles with special reference to the significance of cytometric aneuploidy and literature review. Cytometry 22 (1995) 135-138
11. Fukunaga M., Katabuchi H., Nagasaka T., et al. Interobserver and intraobserver variability in the diagnosis of hydatidiform mole. Am. J. Surg. Pathol. 29 (2005) 942-947
12. Fukunaga M., Ushigome S., Fukunaga M., et al. Application of flow cytometry in diagnosis of hydatidiform moles. Mod. Pathol. 6 (1993) 353-359
13. Fukunaga M. Early partial hydatidiform mole: prevalence, histopathology, DNA ploidy, and persistence rate. Virchows Arch. 437 (2000) 180-184
14. Fukunaga M. Flow cytometric and clinicopathologic study of complete hydatidiform moles with special reference to the significance of cytometric aneuploidy. Gynecol. Oncol. 81 (2001) 67-70
15. Genest D.R., Dorfman D.M., and Castrillon D.H. Ploidy and imprinting in hydatidiform moles. Complementary use of flow cytometry and immunohistochemistry of the imprinted gene product p57KIP2 to assist molar classification. J. Reprod. Med. 47 (2002) 342-346
16. Genest D.R., Ruiz R.E., Weremowicz S., et al. Do nontriploid partial hydatidiform moles exist? A histologic and flow cytometric reevaluation of nontriploid specimens. J. Reprod. Med. 47 (2002) 363-368
17. Gschwendtner A., Neher A., Kreczy A., et al. DNA ploidy determination of early molar pregnancies by image analysis: comparison to histologic classification. Arch. Pathol. Lab. Med. 122 (1998) 1000-1004
18. Guo L., Tang M., Ye S., et al. Flow cytometry used to distinguish between complete and partial hydatidiform moles. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 17 (1995) 65-67
19. Hitchcock C.L., Conran R.M., and Griffin J.L. Hydatidiform moles and the use of flow cytometry in their diagnosis. Perspect. Pediatr. Pathol. 15 (1991) 117-141
20. Honore L.H., Dill F.J., and Poland B.J. The association of hydatidiform mole and trisomy 2. Obstet. Gynecol. 43 (1974) 232-237
21. Jacobs P.A., Szulman A.E., Funkhouser J., et al. Human triploidy: relationship between parental origin of the additional haploid complement and development of partial hydatidiform mole. Ann. Hum. Genet. 46 (1982) 223-231
22. Jacobs P.A., Wilson C.M., Sprenkle J.A., et al. Mechanism of origin of complete hydatidiform moles. Nature 286 (1980) 714-716
23. Jaunimaux E., Halder A., and Partington C. A case of partial mole associated with trisomy 13. Ultrasound Obstet. Gynecol. 11 (1998) 62-64
24. Jeffers M.D., Michie B.A., Oakes S.J., et al. Comparison of ploidy analysis by flow cytometry and image analysis in hydatidiform mole and non-molar abortion. Histopathology 27 (1995) 415-421
25. Jeffers M.D., O'Dwyer P., Curran B., et al. Partial hydatidiform mole: a common but underdiagnosed condition. A 3-year retrospective clinicopathological and DNA flow cytometric analysis. Int. J. Gynecol. Pathol. 12 (1993) 315-323
26. Kajii T., and Ohama K. Androgenetic origin of hydatidiform mole. Nature 268 (1977) 633-634
27. Keep D., Zaragoza M.V., Hassold T., et al. Very early complete hydatidiform mole. Hum. Pathol. 27 (1996) 708-713
28. Koenig C., Demopoulos R.I., Vamvakas E.C., et al. Flow cytometric DNA ploidy and quantitative histopathology in partial moles. Int. J. Gynecol. Pathol. 12 (1993) 235-240
29. Lage J.M., Berkowitz R.S., Rice L.W., et al. Flow cytometric analysis of DNA content in partial hydatidiform moles with persistent gestational trophoblastic tumor. Obstet. Gynecol. 77 (1991) 111-115
30. Lage J.M., Mark S.D., Roberts D.J., et al. A flow cytometric study of 137 fresh hydropic placentas: correlation between types of hydatidiform moles and nuclear DNA ploidy. Obstet. Gynecol. 79 (1992) 403-410
31. Lage J.M., and Popek E.J. The role of DNA flow cytometry in evaluation of partial and complete hydatidiform moles and hydropic abortions. Semin. Diagn. Pathol. 10 (1993) 267-274
32. Lage J.M. Gestational trophoblastic tumors: refining histologic diagnoses by using DNA flow and image cytometry. Curr. Opin. Obstet. Gynecol. 6 (1994) 359-363
33. Lai C.Y., Chan K.Y., Khoo US., et al. Analysis of gestational trophoblastic disease by genotyping and chromosome in situ hybridization. Mod. Pathol. 17 (2004) 40-48
34. Lawler S.D., Fisher R.A., and Dent J. A prospective genetic study of complete and partial hydatidiform moles. Am. J. Obstet. Gynecol. 164 (1991) 1270-1277
35. R.D. LeGallo, E.B. Stelow, N.C. Ramirez, et al., Diagnosis of hydatidiform moles using p57 immunohistochemistry and HER2 fluorescent in situ hybridization, Am. J. Clin. Pathol. 129 (2008) 749-755.
36. Maggiori M.S., and Peres L.C. Morphological, immunohistochemical and chromosome in situ hybridization in the differential diagnosis of Hydatidiform Mole and Hydropic Abortion. Eur. J. Obstet. Gynecol. Reprod. Biol. 135 (2007) 170-176
37. Matsui H., Izuka Y., and Sekiya S. Incidence of invasive mole and choriocarcinoma following partial hydatidiform mole. Int. J. Gynaecol. Obstet. 53 (1996) 63-64
38. Menczer J., Girtler O., Zajdel L., et al. Metastatic trophoblastic disease following partial hydatidiform mole: case report and literature review. Gynecol. Oncol. 74 (1999) 304-307
39. Messerli M.L., Parmley T., Woodruff J.D., et al. Inter and intra-pathologist variability in the diagnosis of gestational trophoblastic neoplasia. Obstet. Gynecol. 69 (1987) 622-626
40. Missaoui N., Hmissa S., Mokni M., et al. DNA content analysis in thyroid neoplasms: diagnostic and prognostic interest. Ann. Endocrinol. 66 (2005) 333-339
41. Mosher R., Goldstein D.P., Berkowitz R., et al. Complete hydatidiform mole. Comparison of clinicopathologic features, current and past. J. Reprod. Med. 43 (1998) 21-27
42. Paradinas F.J., Browne P., Fisher R.A., et al. A clinical, histopathological and flow cytometric study of 149 complete moles, 146 partial moles and 107 non-molar hydropic abortions. Histopathology 28 (1996) 101-110
43. Paradinas F.J. The diagnosis and prognosis of molar pregnancy: the experience of the National Referral Centre in London. Int. J. Gynaecol. Obstet. 60 (1998) S57-S64
44. Paradinas F.J. The histological diagnosis of hydatidiform moles. Curr. Diagn. Pathol. 1 (1994) 24-32
45. Rice L.W., Berkowitz R.S., Lage J.M., et al. Persistent gestational trophoblastic tumor after partial hydatidiform mole. Gynecol. Oncol. 36 (1990) 358-362
46. Ruá S., Comino A., Fruttero A., et al. DNA flow cytometric analysis of abortions. A simple method for detection of triploidy and tetraploidy in the trophoblastic cells. Pathologica 87 (1995) 107-111
47. Sumithran E., Cheah P.L., Susil B.J., et al. Problems in the histological assessment of hydatidiform moles: a study on consensus diagnosis and ploidy status by fluorescent in situ hybridization. Pathology 28 (1996) 311-315
48. Sunde L., Mogensen B., Olsen S., et al. Flow cytometric DNA analyses of 105 fresh hydatidiform moles, with correlations to prognosis. Anal. Cell Pathol. 12 (1996) 99-114
49. Szulman A.E., and Surti U. The clinicopathologic profile of the partial hydatidiform mole. Obstet. Gynecol. 59 (1982) 597-602
50. Szulman A.E., and Surti U. The syndromes of hydatidiform mole. I. Cytogenetic and morphologic correlations. Am. J. Obstet. Gynecol. 131 (1978) 665-671
51. Szulman A.E., and Surti U. The syndromes of hydatidiform mole. II. Morphologic evolution of the complete and partial mole. Am. J. Obstet. Gynecol. 132 (1978) 20-27
52. Teng N.N.H., and Ballon S.C. Partial hydatidiform mole with diploid karyotype: report of three cases. Am. J. Obstet. Gynecol. 150 (1984) 961-964
53. Topalovski M., Hankin R.C., Michael C., et al. Ploidy analysis of products of conception by image and flow cytometry with cytogenetic correlation. Am. J. Clin. Pathol. 103 (1995) 409-414
54. van de Kaa C.A., Hanselaar A.G., Hopman A.H., et al. DNA cytometric and interphase cytogenetic analyses of paraffin-embedded hydatidiform moles and hydropic abortions. J. Pathol. 170 (1993) 229-238
55. van de Kaa C.A., Robben J.C., Hopman A.H., et al. Complete hydatidiform mole in twin pregnancy: differentiation from partial mole with interphase cytogenetic and DNA cytometric analyses on paraffin embedded tissues. Histopathology 26 (1995) 123-129
56. van de Kaa C.A., Schijf C.P., de Wilde P.C., et al. The role of deoxyribonucleic acid image cytometric and interphase cytogenetic analyses in the differential diagnosis, prognosis, and clinical follow-up of hydatidiform moles. A report from the Central Molar Registration in The Netherlands. Am. J. Obstet. Gynecol. 177 (1997) 1219-1229
57. Vassilakos P., Riotton G., and Kajii T. Hydatidiform mole: two entities. A morphologic and cytogenetic study with some clinical consideration. Am. J. Obstet. Gynecol. 127 (1977) 167-170
58. Watanabe M., Ghazizadeh M., Konishi H., et al. Interphase cytogenetic and AgNOR analyses of hydatidiform moles. J. Clin. Pathol. 51 (1998) 438-443
59. Williams R.A., Charlton I.G., and Howat A.J. Image analysis DNA densitometry measurements on complete and partial hydatidiform mole and nonmolar products of conception. Int. J. Gynecol. Pathol. 14 (1995) 300-305
60. Yver M., Carles D., and Bloch B. Determination of DNA ploidy by fluorescence in situ hybridization (FISH) in hydatidiform moles: evaluation of FISH on isolated nuclei. Hum. Pathol. 35 (2004) 752-758
61. Zalel Y., and Dgani R. Gestational trophoblastic disease following the evacuation of partial hydatidiform mole: a review of 66 cases. Eur. J. Obstet. Gynecol. Reprod. Biol. 71 (1997) 67-71