Glucocorticoids can arm macrophages for innate immune battle

Brain, Behavior, and Immunity

Volumn 24, Issue 1, 2010, Pages 17-18

  Sorrells, Shawn F ^a   Sapolsky, Robert M ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; PREDNISONE; TOLL LIKE RECEPTOR 2;

ADAPTATION; ADRENAL GLAND; ARTICLE; BRAIN CORTEX; HIPPOCAMPUS; HORMONE RELEASE; HUMAN; INFLAMMATION; INNATE IMMUNITY; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; STRESS;

EID: 71749099805     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2009.10.004     Document Type: Note

References (9)

1. de Pablos R.M., Villaran R.F., Arguelles S., Herrera A.J., Venero J.L., Ayala A., Cano J., and Machado A. Stress increases vulnerability to inflammation in the rat prefrontal cortex. J. Neurosci. 26 (2006) 5709-5719
2. Frank M.G., Miguel Z.D., Watkins L.R., and Maier S.F. Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide. Brain Behav. Immun. 1 (2009) 19-30
3. Gomes J.A., Stevens R.D., Lewin III J.J., Mirski M.A., and Bhardwaj A. Glucocorticoid therapy in neurologic critical care. Crit. Care Med. 33 (2005) 1214-1224
4. Johnson J.D., O'Connor K.A., Deak T., Stark M., Watkins L.R., and Maier S.F. Prior stressor exposure sensitizes LPS-induced cytokine production. Brain Behav. Immun. 16 (2002) 461-476
5. Madrigal J.L., Hurtado O., Moro M.A., Lizasoain I., Lorenzo P., Castrillo A., Bosca L., and Leza J.C. The increase in TNF-alpha levels is implicated in NF-kappaB activation and inducible nitric oxide synthase expression in brain cortex after immobilization stress. Neuropsychopharmacology 26 (2002) 155-163
6. McEwen B.S., Biron C.A., Brunson K.W., Bulloch K., Chambers W.H., Dhabhar F.S., Goldfarb R.H., Kitson R.P., Miller A.H., Spencer R.L., et al. The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions. Brain Res. Brain Res. Rev. 23 (1997) 79-133
7. Munhoz C., Lepsch L., Maita M., Kawamoto E., de Sa Lim L., Avellar M., Sapolsky R., and Scavone C. Chronic unpredictable stress exacerbates LPS-induced activation of NFκB in the frontal cortex and hippocampus via glucocortioid secretion. J. Neurosci. 26 (2006) 3813-3819
8. Sapolsky R.M., Romero L.M., and Munck A.U. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr. Rev. 21 (2000) 55-89
9. Sorrells et al., 2009. The stressed CNS: when glucocorticoids aggravate inflammation, Neuron. doi:10.1016/j.neuron.2009.09.032.