Delta agonist hydroxy bioisosteres: The discovery of 3-((1-benzylpiperidin-4-yl){4-[(diethylamino)carbonyl]phenyl}amino)benzamide with improved delta agonist activity and in vitro metabolic stability

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 21, 2009, Pages 5999-6003

  Griffin, Andrew M ^a   Brown, William ^a   Walpole, Christopher ^a   Coupal, Martin ^a   Adam, Lynda ^a   Gosselin, Mylene ^a   Salois, Dominic ^a   Morin, Pierre Emmanuel ^a   Roumi, Marie ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Bioisosteres; Delta agonism; Metabolic stability

Indexed keywords

3 ((1 BENZYLPIPERIDIN 4 YL) {4 [(DIETHYLAMINO)CARBONYL]PHENYL} AMINO)BENZAMIDE; AMIDE; BENZAMIDE DERIVATIVE; DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR AGONIST; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; PHENOL DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG METABOLISM; DRUG SELECTIVITY; DRUG STABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; RAT;

EID: 71749090439     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.09.068     Document Type: Article

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