Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitors. Part II

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 23, 2009, Pages 6691-6695

  Zhang, Guobao ^a   Ren, Pingda ^a   Gray, Nathanael S ^a   Sim, Taebo ^a   Wang, Xia ^a   Liu, Yi ^a   Che, Jianwei ^a   Dong, Weitong ^a   Tian, Shin Shay ^a   Sandberg, Mark L ^a   Spalding, Tracy A ^a   Romeo, Russell ^a   Iskandar, Maya ^a   Wang, Zhiliang ^a   Seidel, H Martin ^a   Karanewsky, Donald S ^a   He, Yun ^a  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

Autoimmune disease; Kinase inhibitor; Lck inhibitor; Pyrimidine benzimidazoles; Transplantation rejection

Indexed keywords

4 AMINO 6 BENZIMIDAZOLE PYRIMIDINE DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; PROTEIN KINASE INHIBITOR; PROTEIN KINASE LCK INHIBITOR; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; DRUG BINDING; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZIMIDAZOLES; CELL LINE; CELL PROLIFERATION; DRUG DESIGN; DRUG DISCOVERY; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PYRIMIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 71749086550     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.09.123     Document Type: Article

References (11)

1. Straus D.B., and Weiss A. Cell 70 (1992) 585
2. Weil R., and Veillette A. Curr. Top. Microbiol. Immunol. 205 (1996) 63
3. Van Oers N.S., Kileen N., and Weiss A. J. Exp. Med. 183 (1996) 1053
4. Marth J.D., Lewis D.B., Cooke M.P., Mellins E.D., Gearn M.E., Samelson L.E., Wilson C.B., Miller A.D., and Perlmutter R.M. J. Immunol. 142 (1989) 2430
5. Kamens J.S., Ratnofsky S.E., and Hirst G.C. Curr. Opin. Invest. Drugs 2 (2001) 1213
6. Burchat A., Borhani D.W., Calderwood D.J., Hirst G.C., Li B., and Stachlewitz R.F. Bioorg. Med. Chem. Lett. 16 (2006) 118
7. Liu Y., and Gray N.S. Nat. Chem. Biol. 2 (2006) 358
8. Das J., Lin J., Moquin R.V., Shen Z., Spergel S.H., Wityak J., Doweyko A.M., DeFex H.F., Fang Q., Pang S., Pitt S., Shen D.R., Schieven G.L., and Barrish J.C. Bioorg. Med. Chem. Lett. 13 (2003) 2145
9. Zhang G., Ren P., Gray N.S., Sim T., Liu Y., Wang X., Che J., Tian S.S., Sandberg M.L., Spalding T.A., Romeo R., Iskandar M., Chow D., Karanewsky D.S., Seidel H.M., and He Y. Bioorg. Med. Chem. Lett. 18 (2008) 5618
10. Okram B., Nagle A., Adrian F.J., Lee C., Ren P., Wang X., Sim T., Xie Y., Wang X., Xia G., Spraggon G., Warmuth M., Liu Y., and Gray N.S. Chem. Biol. 13 (2006) 779
11. Quintrell N., Lebo R., Varmus H., Bishop J.M., Pettenati M.J., LeBeau M.M., Diaz M.O., and Rowley J.D. Mol. Cell Biol. 7 (1987) 2267