In-vitro and in-vivo evaluation of a new Ti-15Mo-1Bi alloy

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 91, Issue 2, 2009, Pages 643-650

  Lee, Jing Wei ^a   Lin, Dan Jae ^b   Ju, Chien Ping ^c   Yin, Hsiang Shu ^d   Chuang, Cheng Chung ^c   Lin, Jiin Huey Chern ^c  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Bismuth; Bone ingrowth; Cell proliferation; Cell viability; Cell material interaction

Indexed keywords

ANTI-TUMORS; BONE AREA; BONE GROWTH; BONE INGROWTH; BONY TISSUE; CELL VIABILITY; CELL-MATERIAL INTERACTION; IN-VITRO; IN-VITRO TESTS; IN-VIVO; IN-VIVO EXPERIMENTS; METAL PIN; TI-6AL-4V ALLOY;

ALLOYS; ALUMINUM; BIOMECHANICS; BISMUTH; BISMUTH ALLOYS; BONE; CELL PROLIFERATION; CERIUM ALLOYS; FLUORINE CONTAINING POLYMERS; MECHANICAL PROPERTIES; MOLYBDENUM; TITANIUM ALLOYS;

MOLYBDENUM ALLOYS;

ALLOY; BISMUTH; NICKEL; TI 15MO 1BI ALLOY; TITANIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE GROWTH; BONE REGENERATION; CELL STRAIN 3T3; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; FEMUR; FIBROBLAST CULTURE; HISTOLOGY; IMPLANT; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OSSIFICATION; RABBIT;

3T3 CELLS; ALLOYS; ANIMALS; BONE AND BONES; BONE DEVELOPMENT; CELL PROLIFERATION; CELL SURVIVAL; FEMUR; MALE; MATERIALS TESTING; MICE; MICE, INBRED BALB C; PROSTHESES AND IMPLANTS; RABBITS; TITANIUM;

EID: 71649115164     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.31440     Document Type: Article

References (31)

1. Brånemark PI, Hansson BO, Adell R, Breine U, Lindström J, Hallén O, Ohman A. Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. Scand J Plast Reconstr Surg Suppl 1977;16:1-132.
2. Pilliar RM. Modern metal processing for improved load-bearing surgical implants. Biomaterials 1991;12:95-100.
3. Sumner DR, Turner TM, Igloria R, Urban RM, Galante JO. Functional adaptation and ingrowth of bone vary as a function of hip implant stiffness. J Biomech 1998;31:909-917. (Pubitemid 28529566)
4. Gasser B. Design and engineering criteria for titanium devices. In: Brunette DM, Tengvall P, Textor M, Thomsen P, editors. Titanium in Medicine. Berlin: Springer; 2001. p 674.
5. Lincks J, Boyan BD, Blanchard CR, Lohmann CH, Liu Y, Cochran DL, Dean DD, Schwartz Z. Response of MG63 osteoblast-like cells to titanium and titanium alloy is dependent on surface roughness and composition. Biomaterials 1998;19:2219-2232. (Pubitemid 28550378)
6. Rosa AL, Beloti MM. Rat bone marrow cell response to titanium and titanium alloy with different surface roughness. Clin Oral Implants Res 2003;14:43-48.
7. Niinomi M. Fatigue performance and cyto-toxicity of low rigidity titanium alloy, Ti-29Nb-13Ta-4.6Zr. Biomaterials 2003;24:2673-2683.
8. Naganawa T, Ishihara Y, Iwata T, Koide M, Ohguchi M, Ohguchi Y, Murase Y, Kamei H, Sato N, Mizuno M Noguchi T. In vitro biocompatibility of a new titanium-29niobium-13tantalum-4.6zirconium alloy with osteoblast-like MG63 cells. J Periodontol 2004;75:1701-1707.
9. Long M, Rack HJ. Titanium alloys in total joint replacement-A materials science perspective. Biomaterials 1998;19:1621-1639. (Pubitemid 28512843)
10. Ankem S, Greene CA. Recent developments in microstructure/ property relationships of beta titanium alloys. Mater Sci Eng A Struct Mater 1999;263:127-131.
11. Hallab NJ, Vermes C, Messina C, Roebuck KA, Glant TT, Jacobs JJ. Concentration- and composition-dependent effects of metal ions on human MG-63 osteoblasts. J Biomed Mater Res 2002;60:420-433. (Pubitemid 34296812)
12. Eisenbarth E, Velten D, Muller M, Thull R, Breme J. Biocompatibility of beta-stabilizing elements of titanium alloys. Biomaterials 2004;25:5705-5713. (Pubitemid 38624450)
13. Wang K. The use of titanium for medical applications in the USA. Mater Sci Eng A Struct Mater 1996;213:134-137. (Pubitemid 126394529)
14. Kim HM, Takadama H, Kokubo T, Nishiguchi S, Nakamura T. Formation of a bioactive graded surface structure on Ti-15Mo-5Zr-3Al alloy by chemical treatment. Biomaterials 2000;21:353-358. (Pubitemid 30035464)
15. Lin CW, Ju CP, Chern Lin JH. Comparison among mechanical properties of investment-Cast c.p. Ti, Ti-6Al-7Nb and Ti-15Mo-1Bi alloys. Mater Trans JIM 2004;45:1-5.
16. Cheng WW, Chern Lin JH, Ju CP. Bismuth effect on castability and mechanical properties of Ti-6Al-4V alloy cast in copper mold. Mater Lett 2003;57(16/17):2591-2596.
17. Tiekink ERT. Antimony and bismuth compounds in oncology. Crit Rev Oncol Hematol 2002;42:217-224.
18. Desoize B. Metals and metal compounds in cancer treatment. Anticancer Res 2004;24(3a):1529-1544. (Pubitemid 38954674)
19. Webster TJ, Massa-Schlueter EA, Smith JL, Slamovich EB. Osteoblast response to hydroxyapatite doped with divalent and trivalent cations. Biomaterials 2004;25:2111-2121.
20. Huwez F, Pall A, Lyons D, Stewart MJ. Acute renal failure after overdose of colloidal bismuth subcitrate. Lancet 1992;340:1298.
21. Taylor EG, Klenerman P. Acute renal failure after colloidal bismuth subcitrate overdose. Lancet 1990;335:670-671. (Pubitemid 20092704)
22. Erben RG. Embedding of bone samples in methylmethacrylate: An improved method suitable for bone histomorphometry, histochemistry, and immunohistochemistry. J Histochem Cytochem 1997;45:307-313.
23. Kawahara H, Nakakita S, Ito M, Niwa K, Kawahara D, Matsuda S. Electron microscopic investigation on the osteogenesis at titanium implant/bone marrow interface under masticatory loading. J Mater Sci Mater Med 2006;17:717-726. (Pubitemid 44167414)
24. Zhou H, Choong PF, Henderson S, Chou ST, Aspenberg P, Martin TJ, Ng KW. Marrow development and its relationship to bone formation in vivo: A histological study using an implantable titanium device in rabbits. Bone 1995;17:407-415.
25. Wiskott HWA, Belser UC. Lack of integration of smooth titanium surfaces: A working hypothesis based on strains generated in the surrounding bone. Clin Oral Implants Res 1999;10:429-444.
26. Lin DJ, Chuang CC, Chern Lin JH, Lee JW, Ju CP, Yin HS. Bone formation at the surface of low modulus Ti-7.5Mo implants in rabbit femur. Biomaterials 2007;28:2582-2589.
27. Zardiakas LD, Michell DW, Disegi JA. Characterization of Ti-15Mo beta titanium alloy for orthopaedic implant applications. In: Brown SA, Lemons JE, editors.Medical Applications of Titanium and Its Alloys: The Material and Biological Issues, ASTM STP, vol.1272. West Conshohocken: ASTM; 1996. pp 60-75.
28. Jacobs JJ, Skipor AK, Black J, Urban RM, Galante JO. Release and excretion of metal in patients who have a total hip replacement component made of titanium-base alloy. J Bone Joint Surg Am 1991;73:1475-1486.
29. Thompson GJ, Puleo DA. Ti-6Al-4V ion solution inhibition of osteogenic cell phenotype as a function of differentiation timecourse in vitro. Biomaterials 1996;17:1949-1954.
30. Sun ZL, Wataha JC, Hanks CT. Effects of metal ions on osteoblast-like cell metabolism and differentiation. J Biomed Mater Res 1997;34:29-37.
31. Briand GG, Burford N. Bismuth compounds and preparations with biological or medicinal relevance. Chem Rev 1999; 99:2601-2658.