Modification of poorly bioactive sinomenine into more potent immunosuppressive agents by embedding of drug-like fragments

Tetrahedron Letters

Volumn 51, Issue 3, 2010, Pages 485-488

  Lou, Yang Tong ^a   Zhou, Hai Bin ^a   Zou, Jia ^b   Yan, Ling Chen ^b   Bi, En Guan ^b   Sun, Bing ^b   Yao, Zhu Jun ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

Alkaloid; Drug fragment; Immunomodulating activity; Modification; Sinomenine

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PYRAZINE DERIVATIVE; SINOMENINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; MOUSE; NONHUMAN; REACTION ANALYSIS; STRUCTURE ANALYSIS; UVEORETINITIS;

EID: 71649110020     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.11.019     Document Type: Article

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