A Method for Identifying Small-Molecule Aggregators Using Photonic Crystal Biosensor Microplates

Journal of Laboratory Automation

Volumn 14, Issue 6, 2009, Pages 348-359

  Chan, Leo L ^a   Lidstone, Erich A ^a   Finch, Kristin E ^b   Heeres, James T ^c   Hergenrother, Paul J ^b,c   Cunningham, Brian T ^a  

^a University of Illinois at Urbana Champaign   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

aggregation; aggregator; biosensor; drug like; drug screening; high throughput screening; photonic crystal; small molecule

Indexed keywords

ALTERNATIVE METHODS; COLORIMETRIC ASSAYS; DIRECT MEASUREMENT; DLS MEASUREMENTS; DRUG SCREENING; ESSENTIAL ELEMENTS; FALSE POSITIVE; HIGH-THROUGHPUT; HIGH-THROUGHPUT SCREENING; LABEL-FREE DETECTION METHOD; MASS DENSITIES; MICROPLATES; OPTICAL BIO-SENSORS; PHARMACEUTICAL DISCOVERY; SCREENING ASSAYS; SCREENING PROCESS; SEM; SMALL MOLECULES; SPHERICAL PARTICLE; TARGET PROTEINS; TRANSDUCER SURFACE; VISUAL OBSERVATIONS;

AGGREGATES; BIOASSAY; BIOSENSORS; DYNAMIC LIGHT SCATTERING; DYNAMIC LOADS; FLUORINE CONTAINING POLYMERS; MATERIALS HANDLING; MOLECULES; PHOTONIC CRYSTALS; SCANNING ELECTRON MICROSCOPY; SIGNAL TRANSDUCTION; THROUGHPUT;

AGGLOMERATION;

BIOTIN; BUFFER; CONGO RED; DETERGENT; DIMETHYL SULFOXIDE;

ARTICLE; BIOSENSOR; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; COLORIMETRY; CONTROLLED STUDY; ENZYMATIC ASSAY; HIGH THROUGHPUT SCREENING; LIGHT SCATTERING; MOLECULAR LIBRARY; MOLECULAR WEIGHT; PHOTONIC CRYSTAL BIOSENSOR MICROPLATE; PROTEIN TARGETING; SCANNING ELECTRON MICROSCOPY; SMALL MOLECULE AGGREGATION;

EID: 71649109801     PISSN: 22110682     EISSN: 15402452     Source Type: Journal    
DOI: 10.1016/j.jala.2009.06.008     Document Type: Article

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