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Volumn 43, Issue 6, 2009, Pages 241-250

Downregulation of peroxisome proliferator-activated receptor a and its coactivators in liver and skeletal muscle mediates the metabolic adaptations during lactation in mice

Author keywords

[No Author keywords available]

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; TRIACYLGLYCEROL;

EID: 71649095856     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1677/JME-09-0064     Document Type: Article
Times cited : (23)

References (36)
  • 1
    • 0035847001 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. a link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell
    • DOI 10.1074/jbc.M006246200
    • Barbera MJ, Schlüter A, Pedraza N, Iglesias R, Villaroya F & Giralt M 2000 Peroxisome proliferator-activated receptor a activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of thermogenic and lipid oxidation pathways in the brown fat cell. Journal of Biological Chemistry 276 1486-1493. (Pubitemid 32096582)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.2 , pp. 1486-1493
    • Barbera, M.J.1    Schluter, A.2    Pedraza, N.3    Iglesias, R.4    Villarroya, F.5    Giralt, M.6
  • 2
    • 0030988140 scopus 로고    scopus 로고
    • Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression
    • DOI 10.1016/S0014-5793(97)00384-0, PII S0014579397003840
    • Boss O, Samec S, Paoloni-Giacobino A, Rossier C, Dulloo A, Seydoux J, Muzzin P & Giacobino JP 1997 Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Letters 408 39-42. (Pubitemid 27216458)
    • (1997) FEBS Letters , vol.408 , Issue.1 , pp. 39-42
    • Boss, O.1    Samec, S.2    Paoloni-Giacobino, A.3    Rossier, C.4    Dulloo, A.5    Seydoux, J.6    Muzzin, P.7    Giacobino, J.-P.8
  • 3
    • 0344915176 scopus 로고    scopus 로고
    • Activators of peroxisome proliferator-activated receptor-alpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: A potential mechanism for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth
    • DOI 10.2337/diabetes.48.6.1217
    • Bruns S, Carmona MC, Mamperl T, Vinas O, Giralt M, Igleasias R & Villaroya F 1999 Activators of peroxisome proliferators-activated receptor a induce the expression of the uncoupling protein-3 gene in skeletal muscle: a potential for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth. Diabetes 48 1217-1222. (Pubitemid 29241017)
    • (1999) Diabetes , vol.48 , Issue.6 , pp. 1217-1222
    • Brun, S.1    Carmona, M.C.2    Mampel, T.3    Vinas, O.4    Giralt, M.5    Iglesias, R.6    Villarroya, F.7
  • 4
    • 0035212603 scopus 로고    scopus 로고
    • Oxidized frying oil up-regulates hepatic acyl-CoA oxidase and cytochrome P450 4A1 genes in rats and activates PPARa
    • Chao PM, Chao CY, Lin FJ & Huang CJ 2001 Oxidized frying oil up-regulates hepatic acyl-CoA oxidase and cytochrome P450 4A1 genes in rats and activates PPARa. Journal of Nutrition 131 3166-3174.
    • (2001) Journal of Nutrition , vol.131 , pp. 3166-3174
    • Chao, P.M.1    Chao, C.Y.2    Lin, F.J.3    Huang, C.J.4
  • 5
    • 0030854728 scopus 로고    scopus 로고
    • Energy and protein requirements during lactation
    • Dewey KG 1997 Energy and protein requirements during lactation. Annual Review of Nutrition 17 19-36.
    • (1997) Annual Review of Nutrition , vol.17 , pp. 19-36
    • Dewey, K.G.1
  • 6
    • 0018225607 scopus 로고
    • Effects of age, diet and lactation on lipogenesis in rat adipose, liver and mammary tissues
    • Farid M, Baldwin RL, Yang YT, Osborne E & Grichting G 1978 Effects of age, diet and lactation on lipogenesis in rat adipose, liver and mammary tissues. Journal of Nutrition 108 514-524. (Pubitemid 9204346)
    • (1978) Journal of Nutrition , vol.108 , Issue.3 , pp. 514-524
    • Farid, M.1    Baldwin, R.L.2    Yang, Y.T.3
  • 10
    • 58249085228 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor a and enzymes of carnitine biosynthesis in the liver are down-regulated during lactation in rats
    • Gutgesell A, Ringseis R, Brandsch C, Stangl GI, Hirche F & Eder K 2009 Peroxisome proliferator-activated receptor a and enzymes of carnitine biosynthesis in the liver are down-regulated during lactation in rats. Metabolism 58 226-232.
    • (2009) Metabolism , vol.58 , pp. 226-232
    • Gutgesell, A.1    Ringseis, R.2    Brandsch, C.3    Stangl, G.I.4    Hirche, F.5    Eder, K.6
  • 12
    • 0033594980 scopus 로고    scopus 로고
    • A critical role for the peroxisome proliferator-activated receptor a (PPARa) in the cellular fasting response: The PPARa-null mouse as a model of fatty acid oxidation disorders
    • Leone TC, Weinheimer CJ & Kelly DP 1999 A critical role for the peroxisome proliferator-activated receptor a (PPARa) in the cellular fasting response: the PPARa-null mouse as a model of fatty acid oxidation disorders. PNAS 96 7473-7478.
    • (1999) PNAS , vol.96 , pp. 7473-7478
    • Leone, T.C.1    Weinheimer, C.J.2    Kelly, D.P.3
  • 14
    • 0037135623 scopus 로고    scopus 로고
    • Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPARdelta
    • DOI 10.1074/jbc.M203997200
    • Muoio DM, MacLean PS, Lang DB, Li S, Houmard JA, Way JM, Winegar DA, Corton JC, Dohm GL & Kraus WE 2002 Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. Journal of Biological Chemistry 277 26089-26097. (Pubitemid 34967092)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.29 , pp. 26089-26097
    • Muoio, D.M.1    MacLean, P.S.2    Lang, D.B.3    Li, S.4    Houmard, J.A.5    Way, J.M.6    Winegar, D.A.7    Christopher Corton, J.8    Lynis Dohm, G.9    Kraus, W.E.10
  • 15
    • 33644666564 scopus 로고    scopus 로고
    • Plasma free fatty acids and peroxisome proliferator-activated receptor alpha in the control of myocardial uncoupling protein levels
    • DOI 10.2337/diabetes.54.12.3496
    • Murray AJ, Panagia M, Hauton D, Gibbons GF & Clarke K 2005 Plasma free fatty acids and peroxisome proliferator-activated receptor alpha in the control of myocardial uncoupling protein levels. Diabetes 54 3496-34502. (Pubitemid 43334341)
    • (2005) Diabetes , vol.54 , Issue.12 , pp. 3496-3502
    • Murray, A.J.1    Panagia, M.2    Hauton, D.3    Gibbons, G.F.4    Clarke, K.5
  • 16
    • 0033948042 scopus 로고    scopus 로고
    • Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: Fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene
    • Pedraza N, Solanes G, Carmona MC, Iglesias R, Vinas O, Mampel T, Vazquez M, Giralt M & Villarroya F 2000 Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene. Diabetes 49 1224-1230. (Pubitemid 30439099)
    • (2000) Diabetes , vol.49 , Issue.7 , pp. 1224-1230
    • Pedraza, N.1    Solanes, G.2    Carmona, M.C.3    Iglesias, R.4    Vinas, O.5    Mampel, T.6    Vazquez, M.7    Giralt, M.8    Villarroya, F.9
  • 17
    • 0035310474 scopus 로고    scopus 로고
    • Differential regulation of expression of genes encoding uncoupling proteins 2 and 3 in brown adipose tissue during lactation in mice
    • DOI 10.1042/0264-6021:3550105
    • Pedraza N, Solanes G, Iglesias R, Vazquez M, Giralt M & Villarroya F 2001 Differential regulation of expression of genes encoding uncoupling proteins 2 and 3 in brown adipose tissue during lactation in mice. Biochemical Journal 355 105-111. (Pubitemid 32304240)
    • (2001) Biochemical Journal , vol.355 , Issue.1 , pp. 105-111
    • Pedraza, N.1    Solanes, G.2    Iglesias, R.3    Vazquez, M.4    Giralt, M.5    Villarroya, F.6
  • 18
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW 2001 A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Research 29 e45.
    • (2001) Nucleic Acids Research , vol.29
    • Pfaffl, M.W.1
  • 19
    • 0027487229 scopus 로고
    • AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet
    • Reeves PG, Nielsen FH & Fahey GC Jr 1993 AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. Journal of Nutrition 123 1939-1951.
    • (1993) Journal of Nutrition , vol.123 , pp. 1939-1951
    • Reeves, P.G.1    Nielsen, F.H.2    Fahey Jr., G.C.3
  • 20
    • 34548384971 scopus 로고    scopus 로고
    • Oxidized fat reduces milk triacylglycerol concentrations by inhibiting gene expression of lipoprotein lipase and fatty acid transporters in the mammary gland of rats
    • Ringseis R, Dathe C, Muschick A, Brandsch C & Eder K 2007a Oxidized fat reduces milk triacylglycerol concentrations by inhibiting gene expression of lipoprotein lipase and fatty acid transporters in the mammary gland of rats. Journal of Nutrition 137 2056-2061. (Pubitemid 47367265)
    • (2007) Journal of Nutrition , vol.137 , Issue.9 , pp. 2056-2061
    • Ringseis, R.1    Dathe, C.2    Muschick, A.3    Brandsch, C.4    Eder, K.5
  • 21
    • 33845996906 scopus 로고    scopus 로고
    • Dietary oxidized fat prevents ethanol-induced triacylglycerol accumulation and increases expression of PPARa target genes in rat liver
    • Ringseis R, Muschick A & Eder K 2007b Dietary oxidized fat prevents ethanol-induced triacyglycerol accumulation and increases expression of PPARa target genes in rat liver. Journal of Nutrition 137 77-83. (Pubitemid 46052862)
    • (2007) Journal of Nutrition , vol.137 , Issue.1 , pp. 77-83
    • Ringseis, R.1    Muschick, A.2    Eder, K.3
  • 22
    • 34548126519 scopus 로고    scopus 로고
    • Treatment with pharmacological peroxisome proliferator-activated receptor a agonist clofibrate causes upregulation of organic cation transporter 2 in liver and small intestine of rats
    • Ringseis R, Pösel S, Hirche F & Eder K 2007c Treatment with pharmacological peroxisome proliferator-activated receptor a agonist clofibrate causes upregulation of organic cation transporter 2 in liver and small intestine of rats. Pharmacological Research 56 175-183.
    • (2007) Pharmacological Research , vol.56 , pp. 175-183
    • Ringseis, R.1    Pösel, S.2    Hirche, F.3    Eder, K.4
  • 23
    • 33644772426 scopus 로고    scopus 로고
    • Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: Role of Delta5 and Delta6 desaturases, SREBP-1, PPARa, and PGC-1
    • DOI 10.1194/jlr.M500407-JLR200
    • Rodriguez-Cruz M, Tovar AR, Palacios-Gonzalez B, Del Prado M & Torres N 2006 Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Delta5 and Delta6 desaturases, SREBP-1, PPARa, and PGC-1. Journal of Lipid Research 47 553-560. (Pubitemid 43345596)
    • (2006) Journal of Lipid Research , vol.47 , Issue.3 , pp. 553-560
    • Rodriguez-Cruz, M.1    Tovar, A.R.2    Palacios-Gonzalez, B.3    Del Prado, M.4    Torres, N.5
  • 24
    • 0030794057 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors, orphans with ligands and functions
    • DOI 10.1097/00041433-199706000-00006
    • Schoonjans K, Martin G, Staels B & Auwerx J 1997 Peroxisome proliferator-activated receptors, orphans with ligands and functions. Current Opinion in Lipidology 8 159-166. (Pubitemid 27290462)
    • (1997) Current Opinion in Lipidology , vol.8 , Issue.3 , pp. 159-166
    • Schoonjans, K.1    Martin, G.2    Staels, B.3    Auwerx, J.4
  • 25
    • 0036334426 scopus 로고    scopus 로고
    • Integration of the regulation of reproductive function and energy balance: Lactation as a model
    • Smith MS & Grove KL 2002 Integration of the regulation of reproductive function and energy balance: lactation as a model. Frontiers in Neuroendocrinology 23 225-256.
    • (2002) Frontiers in Neuroendocrinology , vol.23 , pp. 225-256
    • Smith, M.S.1    Grove, K.L.2
  • 26
    • 2642574322 scopus 로고    scopus 로고
    • Thermally oxidized dietary fat upregulates the expression of target genes of PPARa in rat liver
    • Sülzle A, Hirche F & Eder K 2004 Thermally oxidized dietary fat upregulates the expression of target genes of PPARa in rat liver. Journal of Nutrition 134 1375-1383.
    • (2004) Journal of Nutrition , vol.134 , pp. 1375-1383
    • Sülzle, A.1    Hirche, F.2    Eder, K.3
  • 28
    • 0019972684 scopus 로고
    • Brown adipose tissue thermogenesis is 'suppressed' during lactation in mice
    • DOI 10.1038/298059a0
    • Trayhurn P, Douglas JB & McGuckin MM 1982 Brown adipose tissue thermogenesis is suppressed during lactation in mice. Nature 298 59-60. (Pubitemid 12087473)
    • (1982) Nature , vol.298 , Issue.5869 , pp. 59-60
    • Trayhurn, P.1    Douglas, J.B.2    McGuckin, M.M.3
  • 29
    • 0031560941 scopus 로고    scopus 로고
    • UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
    • DOI 10.1006/bbrc.1997.6740
    • Vidal-Puig A, Solanes G, Grujic D, Flier JS & Lowell BB 1997 UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochemical and Biophysical Research Communications 235 79-82. (Pubitemid 27302688)
    • (1997) Biochemical and Biophysical Research Communications , vol.235 , Issue.1 , pp. 79-82
    • Vidal-Puig, A.1    Solanes, G.2    Grujic, D.3    Flier, J.S.4    Lowell, B.B.5
  • 30
    • 0017744690 scopus 로고
    • Effects of lactation on ketogenesis from oleate or butyrate in rat hepatocytes
    • Whitelaw E & Williamson DH 1977 Effects of ketogenesis from oleate or butyrate in rat hepatocytes. Biochemical Journal 164 521-528. (Pubitemid 8132904)
    • (1977) Biochemical Journal , vol.164 , Issue.3 , pp. 521-528
    • Whitelaw, E.1    Williamson, D.H.2
  • 32
    • 0842269824 scopus 로고    scopus 로고
    • Inhibition of Uncoupling Protein Expression during Lactation: Role of Leptin
    • DOI 10.1210/en.2003-0836
    • Xiao XQ, Grove KL, Grayson BE & Smith MS 2004a Inhibition of uncoupling protein expression during lactation: role of leptin. Endocrinology 145 830-838. (Pubitemid 38183827)
    • (2004) Endocrinology , vol.145 , Issue.2 , pp. 830-838
    • Xiao, X.Q.1    Grove, K.L.2    Grayson, B.E.3    Smith, M.S.4
  • 33
    • 9244234945 scopus 로고    scopus 로고
    • Metabolic adaptations in skeletal muscle during lactation: Complementary deoxyribonucleic acid microarray and real-time polymerase chain reaction analysis of gene expression
    • Xiao XQ, Grove KL & Smith MS 2004b Metabolic adaptations in skeletal muscle during lactation: complementary deoxyribonucleic acid microarray and real-time polymerase chain reaction analysis of gene expression. Endocrinology 145 5344-5354.
    • (2004) Endocrinology , vol.145 , pp. 5344-5354
    • Xiao, X.Q.1    Grove, K.L.2    Smith, M.S.3
  • 34
    • 0035085845 scopus 로고    scopus 로고
    • Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor a in the adult rodent heart
    • DOI 10.1096/fj.00-0351com
    • Young ME, Patil S, Ying J, Depre C, Ahuja HS, Shipley GL, Stepkowski SM, Davies PJ & Taegtmeyer H 2001 Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor a in the adult rodent heart. FASEB Journal 15 833-845. (Pubitemid 32246002)
    • (2001) FASEB Journal , vol.15 , Issue.3 , pp. 833-845
    • Young, M.E.1    Patil, S.2    Ying, J.3    Depre, C.4    Ahuja, H.S.5    Shipley, G.L.6    Stepkowski, S.M.7    Davies, P.J.A.8    Taegtmeyer, H.9
  • 35
    • 34547604561 scopus 로고    scopus 로고
    • Transcription coactivators for peroxisome proliferator-activated receptors
    • DOI 10.1016/j.bbalip.2007.01.008, PII S138819810700011X
    • Yu S & Reddy JK 2007 Transcription coactivators for peroxisome proliferator-activated receptors. Biochimica et Biophysica Acta 1771 936-951. (Pubitemid 47198542)
    • (2007) Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids , vol.1771 , Issue.8 , pp. 936-951
    • Yu, S.1    Reddy, J.K.2
  • 36
    • 0019135034 scopus 로고
    • The effect of glucagons treatment and starvation of virgin and lactating rats on the rates of oxidation of octanoyl-Lcarnitine and octanoate by isolated liver mitochondria
    • Zammit VA 1980 The effect of glucagons treatment and starvation of virgin and lactating rats on the rates of oxidation of octanoyl-Lcarnitine and octanoate by isolated liver mitochondria. Biochemical Journal 190 293-300.
    • (1980) Biochemical Journal , vol.190 , pp. 293-300
    • Zammit, V.A.1


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