Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure

Neuropharmacology

Volumn 58, Issue 1, 2010, Pages 185-194

  Winrow, Christopher J ^a   Tanis, Keith Q ^a   Reiss, Duane R ^a   Rigby, Alison M ^a   Uslaner, Jason M ^a   Uebele, Victor N ^a   Doran, Scott M ^a   Fox, Steven V ^a   Garson, Susan L ^a   Gotter, Anthony L ^a   Levine, David M ^a   Roecker, Anthony J ^a   Coleman, Paul J ^a   Koblan, Kenneth S ^a   Renger, John J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Gene expression; Orexin; Plasticity; Sleep; Stimulant

Indexed keywords

AMPHETAMINE; CENTRAL STIMULANT AGENT; N BIPHENYL 2 YL 1 [[(1 METHYL 1H BENZIMIDAZOL 2 YL)SULFANYL]ACETYL] LEVO PROLINAMIDE; NICOTINE; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AROUSAL; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DRUG EXPOSURE; DRUG SELECTIVITY; DRUG SENSITIZATION; DRUG STRUCTURE; FOOD INTAKE; GENE EXPRESSION PROFILING; MALE; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RAT; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION;

AMPHETAMINE; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; BENZIMIDAZOLES; CENTRAL NERVOUS SYSTEM STIMULANTS; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MALE; MOTOR ACTIVITY; NICOTINE; NICOTINIC AGONISTS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OLIGOPEPTIDES; PROLINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; REINFORCEMENT (PSYCHOLOGY); RNA, MESSENGER; SLEEP; TRANSCRIPTION, GENETIC; VENTRAL TEGMENTAL AREA;

EID: 71649092222     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2009.07.008     Document Type: Article

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